Results 51 to 60 of about 347,689 (338)

DC-SIGN Binding Contributed by an Extra N-Linked Glycosylation on Japanese Encephalitis Virus Envelope Protein Reduces the Ability of Viral Brain Invasion

Frontiers in Cellular and Infection Microbiology, 2018
The major structural envelope (E) protein of Japanese encephalitis virus (JEV) facilitates cellular binding/entry and is the primary target of neutralizing antibodies.
Jian-Jong Liang, Min-Wei Chou, Yi-Ling Lin, Yi-Ling Lin   +3 more
doaj   +1 more source

The Nicastrin ectodomain adopts a highly thermostable structure [PDF]

, 2011
Nicastrin is a type I transmembrane glycoprotein, which is part of the high molecular weight gamma-secretase complex. gamma-Secretase is one of the key players associated with the generation of Alzheimer's disease pathology, since it liberates the ...
Beyer, Klaus, Fluhrer, Regina, Grammer, Gudula, Haass, Christian, Kamp, Frits, Nuscher, Brigitte, Steiner, Harald   +6 more
core   +2 more sources

Getting Sugar Coating Right! The Role of the Golgi Trafficking Machinery in Glycosylation

Cells, 2021
The Golgi is the central organelle of the secretory pathway and it houses the majority of the glycosylation machinery, which includes glycosylation enzymes and sugar transporters. Correct compartmentalization of the glycosylation machinery is achieved by
Zinia D’Souza, Farhana Taher Sumya, Amrita Khakurel, Vladimir Lupashin   +3 more
doaj   +1 more source

A human embryonic kidney 293T cell line mutated at the Golgi -mannosidase II locus [PDF]

, 2009
Disruption of Golgi -mannosidase II activity can result in type II congenital dyserythropoietic anemia and can induce lupus-like autoimmunity in mice.
Max Crispin, Veronica T. Chang, David J. Harvey, Raymond A. Dwek, Edward J. Evans, David I. Stuart, E. Yvonne Jones, J. Michael Lord, Robert A. Spooner, Simon J. Davis, Kornfeld, Balaguer, Neusüss, Parodi, Herscovics, Tremblay, Lal, Schachter, Jaeken, Fukuda, Fukuda, Lowe, Green, Paulson, Patnaik, Martinez-Duncker, Hong, Sethuraman, Hoppe, Davis, Davis, Butters, Chang, Stanley, Dwek, Hamilton, Li, Hamilton, Reeves, Gleeson, Hughes, Hughes, Foddy, Paschinger, Aghi, Bebbington, Davis, Aricescu, Durocher, Küster, Börnsen, Harvey, Harvey, Harvey, Harvey, Olsnes, Watson, Spooner, Spooner, Crispin, Crispin, Oh-Eda, Harvey, Domon, Chen, Shah, Moremen, Butler, Choi, Wu, Foulquier   +70 more
core   +2 more sources

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Diverse biological effects of glycosyltransferase genes from Tartary buckwheat [PDF]

, 2019
Background: Tartary buckwheat (Fagopyrum tataricum) is an edible cereal crop whose sprouts have been marketed and commercialized for their higher levels of anti-oxidants, including rutin and anthocyanin. UDP-glucose flavonoid glycosyltransferases (UFGTs)
Chen, Hui, Deng, Renyu, Dong, Qixin, Huang, Yunji, Li, Chenglei, Li, Qi, Lv, Bingbing, Shi, Guanlan, Shi, Jiaqi, Stael, Simon, Wu, Qi, Yao, Panfeng, Zhao, Haixia   +12 more
core   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Stereoselective glycosylations using oxathiane spiroketal glycosyl donors [PDF]

Carbohydrate Research, 2012
Novel oxathiane spiroketal donors have been synthesised and activated via an umpolung S-arylation strategy using 1,3,5-trimethoxybenzene and 1,3-dimethoxybenzene. The comparative reactivity of the resulting 2,4,6-trimethoxyphenyl (TMP)- and 2,4-dimethoxyphenyl (DMP)-oxathiane spiroketal sulfonium ions is discussed, and their α-stereoselectivity in ...
Fascione, MA, Webb, NJ, Kilner, CA, Warriner, SL, Turnbull, WB   +4 more
openaire   +3 more sources

Physical and chemical processes and the morphofunctional characteristics of human erythrocytes in hyperglycaemia [PDF]

, 2017
Background: This study examines the effect of graduated hyperglycaemia on the state and oxygen-binding ability of hemoglobin, the correlation of phospholipid fractions and their metabolites in the membrane, the activity of proteolytic enzymes and the ...
Bourdon, Jean Christophe, Gromova, Natalia V., Grunyushkin, Igor P., Klenova, Natalia A., Pestryakova, Anastasia A., Prosnikova, Ksenia V., Revin, Victor V., Revina, Elvira S., Sadykhova, Anna V., Solomadin, Ilia N., Tychkov, Alexander Y., Zhelev, Nikolai   +11 more
core   +5 more sources