Results 101 to 110 of about 41,434 (212)

NRN1 as a therapeutic target for Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Neuritin‐1 (NRN1) was identified as a synaptic protein associated with cognitive resilience to Alzheimer's disease (AD). METHODS Target risk score and cell type expression profiles were generated for NRN1 using methods developed by the Emory‐Sage‐SGC‐JAX Target Enablement to Accelerate Therapy Development for Alzheimer's Disease ...
Derian A. Pugh, Gregory A. Cary, Kelsey M. Greathouse, Lauren C. Nassour‐Caswell, Emma L. Hobby, Nicholas T. Seyfried, Jeremy H. Herskowitz   +6 more
wiley   +1 more source

Peritumoral administration of GPI-anchored TIMP-1 inhibits colon carcinoma growth in Rag-2 gamma chain-deficient mice [PDF]

, 2009
Exogenous application of recombinant TIMP-1 protein modified by addition of a glycosylphosphatidylinositol (GPI) anchor allows efficient insertion of the fusion protein into cell membranes.
Djafarzadeh, Roghieh, Hofstetter, Monika, Jahn, Birgit, Muenchmeier, Niklas, Nelson, Peter J., Raggi, Matthias C., Rieth, Nicole   +6 more
core   +1 more source

Biosynthesis and deficiencies of glycosylphosphatidylinositol

Proceedings of the Japan Academy, Series B, 2014
At least 150 different human proteins are anchored to the outer leaflet of the plasma membrane via glycosylphosphatidylinositol (GPI). GPI preassembled in the endoplasmic reticulum is attached to the protein's carboxyl-terminus as a post-translational modification by GPI transamidase. Twenty-two PIG (for Phosphatidyl Inositol Glycan) genes are involved
openaire   +3 more sources

Metabolic reprogramming of efferocytosis in the tumour microenvironment: From apoptotic‐cell clearance to therapeutic targeting

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
This review systematically deconstructs the pathological efferocytic—metabolic axis in tumours, framing it as a three‐stage, self‐reinforcing cycle: from metabolite‐driven macrophage recruitment, through hijacked surface recognition, to post‐phagocytic metabolic reprogramming that locks in immunosuppression.
Qianlu Yang, Jie Yan, Qianxi Yang
wiley   +1 more source

Association of SOGPI in mediating the effect of Phosphatidylcholine on polycystic Ovary Syndrome

Gynecological Endocrinology
Background Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder in women of reproductive age, marked by hormonal imbalances and disruptions in glucose and lipid metabolism.
Qian Guo, Wei Wang, Jie Chen, Wei-rong Ma, Yingqian Yang, Yong Tan   +5 more
doaj   +1 more source

Detection of paroxysmal nocturnal hemoglobinuria clones in patients with myelodysplastic syndromes and related bone marrow diseases, with emphasis on diagnostic pitfalls and caveats

Haematologica, 2009
Background The presence of paroxysmal nocturnal hemoglobinuria clones in the setting of aplastic anemia or myelodysplastic syndrome has been shown to have prognostic and therapeutic implications. However, the status of paroxysmal nocturnal hemoglobinuria
Sa A. Wang, Olga Pozdnyakova, Jeffrey L. Jorgensen, L. Jeffrey Medeiros, Dariusz Stachurski, Mary Anderson, Azra Raza, Bruce A. Woda   +7 more
doaj   +1 more source

Expression and Circular Dichroism Studies of the Extracellular Domain of the alpha Subunit of the Nicotinic Acetylcholine Receptor [PDF]

, 1997
To provide material suitable for structural studies of the nicotinic acetylcholine receptor, we have expressed and purified the NH2-terminal extracellular domain of the mouse muscle alpha subunit.
Bjorkman, Pamela J., Dougherty, Dennis A., Lester, Henry A., West, Anthony P., Jr.   +3 more
core  

Integrative Omics Analysis Reveals the Potential Value of CEACAM6 in Pan‐Gastrointestinal Cancers

Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.
Expression of CEACAM6 in spatial transcriptomic of colorectal cancer with liver metastases. (A) Predicted cell types mapping on colorectal cancer tissue slice; (B) Spatial distribution of CEACAM6; (C) Spatial distribution of malignant region, mixed region and normal region; (D) The difference expression of CEACAM6 in malignant region, mixed region and ...
Liying Jin, Changjuan Tao, Zhiyong Pan, Peng Zhang   +3 more
wiley   +1 more source

Jawsamycin exhibits in vivo antifungal properties by inhibiting Spt14/Gpi3-mediated biosynthesis of glycosylphosphatidylinositol

Nature Communications, 2020
Biosynthesis of glycosylphosphatidylinositol (GPI) is essential for the integrity of the fungal cell wall. Here, the authors show that the natural product jawsamycin inhibits GPI biosynthesis by targeting a subunit of the fungal UDP-glycosyltransferase ...
Yue Fu, David Estoppey, Silvio Roggo, Dominik Pistorius, Florian Fuchs, Christian Studer, Ashraf S. Ibrahim, Thomas Aust, Frederic Grandjean, Manuel Mihalic, Klaus Memmert, Vivian Prindle, Etienne Richard, Ralph Riedl, Sven Schuierer, Eric Weber, Jürg Hunziker, Frank Petersen, Jianshi Tao, Dominic Hoepfner   +19 more
doaj   +1 more source

A multifunctional, synthetic Gaussia princeps luciferase reporter for live imaging of Candida albicans infections [PDF]

, 2009
Peer reviewedPublisher ...
Brown, Alistair J P, d'Enfert, Christophe, Enjalbert, Brice, Pietrella, Donatella, Rachini, Anna, Spaccapelo, Roberta, Vecchiarelli, Anna, Vediyappan, Govindsamy   +7 more
core   +4 more sources