Results 11 to 20 of about 41,434 (212)

GPI-AP: Unraveling a New Class of Malignancy Mediators and Potential Immunotherapy Targets

Frontiers in Oncology, 2020
With millions of cases diagnosed annually and high economic burden to cover expensive costs, cancer is one of the most difficult diseases to treat due to late diagnosis and severe adverse effects from conventional therapy.
Nada H. Hussein, Nada S. Amin, Hend M. El Tayebi   +2 more
doaj   +1 more source

New Players in Neuronal Iron Homeostasis: Insights from CRISPRi Studies

Antioxidants, 2022
Selective regional iron accumulation is a hallmark of several neurodegenerative diseases, including Alzheimer’s disease and Parkinson’s disease. The underlying mechanisms of neuronal iron dyshomeostasis have been studied, mainly in a gene-by-gene ...
Daniel A. Bórquez, Francisco Castro, Marco T. Núñez, Pamela J. Urrutia   +3 more
doaj   +1 more source

Major Surface Antigens in Zoonotic Babesia

Pathogens, 2022
Human babesiosis results from a combination of tick tropism for humans, susceptibility of a host to sustain Babesia development, and contact with infected ticks.
Stephane Delbecq
doaj   +1 more source

Compound Heterozygous PIGS Variants Associated With Infantile Spasm, Global Developmental Delay, Hearing Loss, Visual Impairment, and Hypotonia

Frontiers in Genetics, 2020
Glycosylphosphatidylinositol (GPI) is a membrane anchor for cell surface proteins. Inherited GPI deficiencies are a new subclass of congenital disorders of glycosylation.
Lily Zhang, Xiao Mao, Hongyu Long, Bo Xiao, Zhaohui Luo, Wenbiao Xiao, Xingbing Jin   +6 more
doaj   +1 more source

Thematic Review Series: Glycosylphosphatidylinositol (GPI) Anchors: Biochemistry and Cell Biology Biosynthesis of GPI-anchored proteins: special emphasis on GPI lipid remodeling

Journal of Lipid Research, 2016
Glycosylphosphatidylinositols (GPIs) act as membrane anchors of many eukaryotic cell surface proteins. GPIs in various organisms have a common backbone consisting of ethanolamine phosphate (EtNP), three mannoses (Mans), one non-N-acetylated glucosamine ...
Taroh Kinoshita, Morihisa Fujita
doaj   +1 more source

Genomic Organization, Splice Variants and Expression of CGMl, a CD66-related Member of the Carcinoembryonic Antigen Gene Family [PDF]

, 1993
The tumor marker carcinoembryonic antigen (CEA) belongs to a family of proteins which are composed of one immunogiobulin variable domain and a varying number of immunoglobulin constant-like domains.
Afar D. E. H., Audette M., Baniyash M., Berling B., Culic O., Elsen P., Felgner P. L., Fiddes J. C., Knapp W., Kolbinger F., Kuroki M., Kuroki M., Kuroki M., Lin S.-H., Lucas K., Margolis R. N., McCuaig K., Nap M., Neumaier M., Ng S. Y., Oikawa S., Oikawa S., Paxton R., Pelegrin A., Raskind W. H., Rojas M., Sambrook J. E., Schwarz K., Shively J. E., Skubitz K. M., Southern P. J., Thompson J. A., Thompson J. A., Turbide C., Tynan K., Watt S. M., Woodgett J. R., Zhou H.   +37 more
core   +6 more sources

Turnover of Variant Surface Glycoprotein in Trypanosoma brucei Is Not Altered in Response to Specific Silencing

mSphere, 2022
African trypanosomes evade the immune system of the mammalian host by the antigenic variation of the predominant glycosylphosphatidylinositol (GPI)-anchored surface protein, variant surface glycoprotein (VSG).
Mohamed Sharif, Paige Garrison, Peter Bush, James D. Bangs   +3 more
doaj   +1 more source

Asymptomatic infection in individuals from the municipality of Barcelos (Brazilian Amazon) is not associated with the anti-Plasmodium falciparum glycosylphosphatidylinositol antibody response

Memorias do Instituto Oswaldo Cruz, 2013
Anti-glycosylphosphatidylinositol (GPI) antibodies (Abs) may reflect and mediate, at least partially, anti-disease immunity in malaria by neutralising the toxic effect of parasitic GPI.
Larissa Rodrigues Gomes, Paulo Renato Rivas Totino, Maria Carmen Arroyo Sanchez, Elsa Paula da Silva Kaingona Daniel, Cristiana Santos de Macedo, Filomeno Fortes, Jose Rodrigues Coura, Silvia Maria Di Santi, Guilherme Loureiro Werneck, Martha Cecilia Suarez-Mutis, Maria de Fatima Ferreira-da-Cruz, Claudio Tadeu Daniel-Ribeiro   +11 more
doaj   +1 more source

Single-domain antibodies and their formatting to combat viral infections [PDF]

, 2018
Since their discovery in the 1990s, single-domain antibodies (VHHs), also known as NanobodiesA (R), have changed the landscape of affinity reagents. The outstanding solubility, stability, and specificity of VHHs, as well as their small size, ease of ...
Ballegeer, Marlies, De Vlieger, Dorien, Rossey, Iebe, Saelens, Xavier, Schepens, Bert   +4 more
core   +2 more sources

GPI-specific phospholipase D associates with an apoA-I- and apoA-IV-containing complex

Journal of Lipid Research, 2001
Glycosylphosphatidylinositol-specific phospholipase D (GPI-PLD) is abundant in serum and associates with high density lipoproteins (HDL). We have characterized the distribution of GPI-PLD among lipoproteins in human plasma.
Mark A. Deeg, Edwin L. Bierman, Marian C. Cheung   +2 more
doaj   +1 more source