Results 31 to 40 of about 41,434 (212)

Glycosylphosphatidylinositol biosynthesis and remodeling are required for neural tube closure, heart development, and cranial neural crest cell survival

eLife, 2019
Glycosylphosphatidylinositol (GPI) anchors attach nearly 150 proteins to the cell membrane. Patients with pathogenic variants in GPI biosynthesis genes develop diverse phenotypes including seizures, dysmorphic facial features and cleft palate through an ...
Marshall Lukacs, Tia Roberts, Praneet Chatuverdi, Rolf W Stottmann   +3 more
doaj   +1 more source

The Glycosylphosphatidylinositol biosynthesis pathway in human diseases

Orphanet Journal of Rare Diseases, 2020
Glycosylphosphatidylinositol biosynthesis defects cause rare genetic disorders characterised by developmental delay/intellectual disability, seizures, dysmorphic features, and diverse congenital anomalies associated with a wide range of additional ...
Tenghui Wu, Fei Yin, Shiqi Guang, Fang He, Li Yang, Jing Peng   +5 more
doaj   +1 more source

The developmental cell biology of Trypanosoma brucei [PDF]

, 2005
Trypanosoma brucei provides an excellent system for studies of many aspects of cell biology, including cell structure and morphology, organelle positioning, cell division and protein trafficking. However, the trypanosome has a complex life cycle in which
Matthews, Keith R
core   +2 more sources

Biochemical characterization of the initial steps of the Kennedy pathway in Trypanosoma brucei:the ethanolamine and choline kinases [PDF]

, 2008
Note related output below contains correction of this paper.Ethanolamine and choline are major components of the trypanosome membrane phospholipids, in the form of GPEtn (glycero-phosphoethanolamine) and GPCho (glycerophosphocholine).
Ayoama, Baba, Bürgemaister, Chang, Choubey, Clary, Cuadrado, Dowhan, Federica Gibellini, Ferguson, Gee, Imhof, Kennedy, Kim, Kim, Malito, Menon, Menon, Nagamune, Patnaik, Peisach, Rifkin, Scheef, Smith, Terry K. Smith, Urbina, Wharfe, William N. Hunter, Yuan   +28 more
core   +8 more sources

Characterization of Arabidopsis Post-Glycosylphosphatidylinositol Attachment to Proteins Phospholipase 3 Like Genes

Frontiers in Plant Science, 2022
Lipid remodeling of Glycosylphosphatidylinositol (GPI) anchors is required for their maturation and may influence the localization and function of GPI-anchored proteins (GPI-APs).
Cesar Bernat-Silvestre, Yingxuan Ma, Yingxuan Ma, Kim Johnson, Kim Johnson, Alejandro Ferrando, Fernando Aniento, María Jesús Marcote   +7 more
doaj   +1 more source

A glycosylphosphatidylinositol-anchored carbonic anhydrase-related protein of Toxoplasma gondii is important for rhoptry biogenesis and virulence [PDF]

, 2017
Carbonic anhydrase-related proteins (CARPs) have previously been described as catalytically inactive proteins closely related to α-carbonic anhydrases (α-CAs).
Beejan Asady, Isabelle Coppens, Jessica C. Kissinger, Leandro Lemgruber, Nathan M. Chasen, Rossiane C. Vommaro, Silvia N. J. Moreno, William J. Sullivan   +7 more
core   +2 more sources

Glycosylphosphatidylinositol Anchoring: Control through Modification [PDF]

PLANT PHYSIOLOGY, 2014
Glycosylphosphatidylinositol-anchor biosynthesis and glycosylphosphatidylinositol modification of proteins are central to coordinated plant development.
Alice Y, Cheung, Chao, Li, Yan-jiao, Zou, Hen-Ming, Wu   +3 more
openaire   +2 more sources

GPIHBP1, a GPI-anchored protein required for the lipolytic processing of triglyceride-rich lipoproteins

Journal of Lipid Research, 2009
GPIHBP1, a small glycosylphosphatidylinositol-anchored glycoprotein, is required for the lipolytic processing of triglyceride-rich lipoproteins. GPIHBP1 knockout mice exhibit chylomicronemia, even on a low-fat diet, with plasma triglyceride levels of 3 ...
Anne P. Beigneux, Brandon S.J. Davies, André Bensadoun, Loren G. Fong, Stephen G. Young   +4 more
doaj   +1 more source

Molecular insights into biogenesis of glycosylphosphatidylinositol anchor proteins

Nature Communications, 2022
GPI-T catalyzes the committed step in GPI anchor protein biogenesis. Here, Xu et al. report the cryo-EM structure of the human GPI-T, revealing critical elements within an elongated, shared active site which is topologically arranged for substrate ...
Yidan Xu, Guowen Jia, Tingting Li, Zixuan Zhou, Yitian Luo, Yulin Chao, Juan Bao, Zhaoming Su, Qianhui Qu, Dianfan Li   +9 more
doaj   +1 more source

Synthesis and structural characterization of a mimetic membrane-anchored prion protein [PDF]

, 2006
During pathogenesis of transmissible spongiform encephalopathies (TSEs) an abnormal form (PrPSc) of the host encoded prion protein (PrPC) accumulates in insoluble fibrils and plaques. The two forms of PrP appear to have identical covalent structures, but
Andrew C. Gill, Ansari AA, Atvinder K. Rullay, Bertozzi CR, Blanch EW, Borchelt D, Caughey B, Caughey B, Caughey B, Caughey BW, Critchley P, David H. Crout, Eberl H, Ferris A, Georges C, Gill AC, Govaerts C, Haire LF, Harris DA, Hornemann S, Ian D. Sylvester, Imanpreet K. Bath, Kazlauskaite J, Kazlauskaite J, Kenyon GL, King SA, Kirby L, Klein TR, Kocienski PJ, Legname G, Matthew R. Hicks, Mui B, Nosjean O, Pan KM, Poss AJ, Safar J, Seddon AM, Shyng SL, Stahl N, Stahl N, Teresa J. T. Pinheiro, Whitesell JK, Wuthrich K, Zahn R, Zhang ZY   +44 more
core   +1 more source