Results 51 to 60 of about 29,448 (207)

Biosynthesis and deficiencies of glycosylphosphatidylinositol

Proceedings of the Japan Academy, Series B, 2014
At least 150 different human proteins are anchored to the outer leaflet of the plasma membrane via glycosylphosphatidylinositol (GPI). GPI preassembled in the endoplasmic reticulum is attached to the protein's carboxyl-terminus as a post-translational modification by GPI transamidase. Twenty-two PIG (for Phosphatidyl Inositol Glycan) genes are involved
openaire   +3 more sources

glycosylphosphatidylinositol anchor biosynthesis-html

, 2014
unigenes associated with glycosylphosphatidylinositol anchor ...
Karen Fugate (480954)
core   +1 more source

Molecular Insights into Fungal Glycosylphosphatidylinositol Transamidase Complex

Advanced Science
The glycosylphosphatidylinositol (GPI) biosynthesis pathway is critical for antifungal drug development. As a key component of this pathway, GPI transamidase (GPIT) catalyzes the attachment of GPI anchors to proteins, a process essential for fungal cell ...
Zhengkang Hua, Xuyang Ding, Yanan Wu, Di Zhang, Xinlin Hu, Ping Yang, Jiameng Li, Yi Tan, Junbo Liu, Mingjie Zhang, Min Zhang, Xiaotian Liu, Hongjun Yu   +12 more
doaj   +1 more source

Sortase-Catalyzed Peptide−Glycosylphosphatidylinositol Analogue Ligation

, 2016
Sortase-Catalyzed Peptide−Glycosylphosphatidylinositol Analogue ...
Benjamin M. Swarts (2298169), Zhongwu Guo (673969), Qianli Wang (2121643), Xueqing Guo (1883581)   +3 more
core   +1 more source

Genome-Wide Screening of Genes Required for Glycosylphosphatidylinositol Biosynthesis. [PDF]

PLoS ONE, 2015
Glycosylphosphatidylinositol (GPI) is synthesized and transferred to proteins in the endoplasmic reticulum (ER). GPI-anchored proteins are then transported from the ER to the plasma membrane through the Golgi apparatus.
Yao Rong, Shota Nakamura, Tetsuya Hirata, Daisuke Motooka, Yi-Shi Liu, Zeng-An He, Xiao-Dong Gao, Yusuke Maeda, Taroh Kinoshita, Morihisa Fujita   +9 more
doaj   +1 more source

Fetal Cells in Maternal Blood for Noninvasive Prenatal Testing—Is it Still a Distant Star?

Prenatal Diagnosis, EarlyView.
ABSTRACT Accurate and safe prenatal diagnosis of severe genetic disorders remains challenging despite advances in genomic technologies and increased use of cell‐free noninvasive prenatal testing (cfNIPT). Currently, approximately half of pathogenic copy number variants (pCNVs) and most monogenic disorders are identified only postnatally.
Ripudaman Singh, Katarina Ravn, Line Dahl Jeppesen, Maria Bach Laursen, Maibritt Nøgaard Lauridsen, Mathias Kølvraa, Marlene Christina Nielsen, Bolette Hestbek Nicolaisen, Inga Baach Cristensen, Morten Muhlig Nielsen, Britt Kidmose Ardal, Lars Henning Pedersen, Mads Tang Dalsgaard, Ida Vogel, Lotte Hatt   +14 more
wiley   +1 more source

Natural Ligand of Mouse CD1d1: Cellular Glycosylphosphatidylinositol

, 1998
Mouse CD1d1, a member of the CD1 family of evolutionarily conserved major histocompatibility antigen–like molecules, controls the differentiation and function of a T lymphocyte subset, NK1 + natural T cells, proposed ...
A. Dharshan De Silva, Jack R. Bennink, Alina Boesteanu, Amina S. Woods, Sebastian Joyce, Randy R. Brutkiewicz, Steven P. Balk, Jonathan W. Yewdell, Robert J. Cotter   +8 more
core   +1 more source

Oral Protein Therapy for the Future - Transport of Glycolipid-Modified Proteins: Vision or Fiction? [PDF]

, 2010
The reliable and early diagnosis of common complex multifactorial diseases depends on the individual determination of all (or as many as possible) polymorphisms of each susceptibility gene together with amount and type of the corresponding gene products ...
Mueller, Guenter, Günter Müller
core   +1 more source

Proteomic Analysis of ARF1‐ and ARF3‐Proximal Proteins at the Trans‐Golgi Network

PROTEOMICS, EarlyView.
ABSTRACT Despite its fundamental importance, the molecular mechanisms of post‐Golgi transport remain incompletely understood. Carrier formation of post‐Golgi transport depends on ARF3 and ARF1, very close paralogs; the former localizes on the trans‐Golgi network (TGN) whereas the latter localizes on TGN and cis‐Golgi.
Taisei Uehara, Reiko Nakagawa, Takunori Satoh, Akiko K. Satoh   +3 more
wiley   +1 more source

Hypotonia and intellectual disability without dysmorphic features in a patient with PIGN-related disease

BMC Medical Genetics, 2017
Background Defects in the human glycosylphosphatidylinositol anchor biosynthetic pathway are associated with inherited glycosylphosphatidylinositol (GPI)-deficiencies characterized by a broad range of clinical phenotypes including multiple congenital ...
Isabelle Thiffault, Britton Zuccarelli, Holly Welsh, Xuan Yuan, Emily Farrow, Lee Zellmer, Neil Miller, Sarah Soden, Ahmed Abdelmoity, Robert A. Brodsky, Carol Saunders   +10 more
doaj   +1 more source