Results 71 to 80 of about 29,448 (207)

Understanding extracellular vesicle biology, isolation, and characterization: The theory of EV‐erything

Periodontology 2000, EarlyView.
Abstract Background Extracellular vesicles (EVs), especially exosomes, are nanoparticles increasingly recognized as key regulators of intercellular communication in both physiological and pathological aspects. Despite rapid progress, inconsistencies in nomenclature, isolation, and characterization continue to restrict translational advancement.
Paras Ahmad, Nima Farshidfar, Nathan E. Estrin, Yulan Wang, Yufeng Zhang, Anton Sculean, Richard J. Miron   +6 more
wiley   +1 more source

Table_2_Spectrum of Neurological Symptoms in Glycosylphosphatidylinositol Biosynthesis Defects: Systematic Review.docx

, 2022
Background: Mutations of genes involved in the synthesis of glycosylphosphatidylinositol and glycosylphosphatidylinositol-anchored proteins lead to rare syndromes called glycosylphosphatidylinositol-anchored proteins biosynthesis defects.
Jagoda Hofman (11897720), Aleksandra Jezela-Stanek (3862963), Robert Śmigiel (11715935), Magdalena Kłaniewska (11897726), Krzysztof Szczałuba (11897729), Agnieszka Tokarska (11897723), Agnieszka Stembalska (11897732), Michał Hutny (11897717), Justyna Paprocka (10713864)   +8 more
core   +1 more source

A PIGG congenital disorder of glycosylation (PIGG‐CDG) variant associated with an Emm− red blood cell phenotype in a pediatric patient

Transfusion, EarlyView.
Abstract Background The high‐prevalence Emm antigen is an epitope on the GPI (glycosylphosphatidylinositol) glycolipid backbone, which anchors proteins to the cell surface. Inherited loss‐of‐function of PIGG (or PIGO) results in the rare Emm− red cell (RBC) phenotype and is associated with congenital disorders of glycosylation (CDG).
Alastair Murray, Connie M. Westhoff, Sunitha Vege, Hallie Lee‐Stroka, Randall W. Velliquette, William J. Lane, Jillian G. Buchan, Nabiha H. Saifee, Rida A. Hasan   +8 more
wiley   +1 more source

Chemoenzymatic synthesis of glycosylphosphatidylinositol-anchored glycopeptides [PDF]

Chemical Communications, 2010
MUC1 glycopeptide was efficiently coupled to glycosylphosphatidylinositol (GPI) derivatives by sortase A (SrtA), verifying that SrtA can accept sterically hindered glycopeptide as substrate for ligation with GPIs. This work has established a practical method for the chemoenzymatic synthesis of GPI-linked glycopeptides.
Zhimeng, Wu, Xueqing, Guo, Zhongwu, Guo
openaire   +2 more sources

Lipidomics coupled with pathway analysis characterizes serum metabolic changes in response to potassium oxonate induced hyperuricemic rats

Lipids in Health and Disease, 2019
Background Hyperuricemia as a metabolic disease is usually associated with lipid metabolic disorder. The purpose of this study is to identify potential lipid biomarkers and provide the evidence for the relationship between hyperuricemia and lipid-related
Fei Yang, Mingyu Liu, Nankun Qin, Shuangshuang Li, Mengqi Yu, Chengxiang Wang, Qun Ma   +6 more
doaj   +1 more source

Can Repeated Reductive Genome Evolution Across Archaeplastida Explain Volatility in Traits?

Advanced Genetics, Volume 7, Issue 4, December 2026.
Genome evolution in Archaeplastida is often framed around gene gains and increasing complexity. Yet ancestral reconstructions reveal recurrent genome contraction, with ancestors frequently harboring larger gene repertoires than descendants. Across red algae, land‐plant ancestry, and embryophyte diversification, repeated expansion and reduction cycles ...
Cäcilia F. Kunz, Merve Nida Baştürk, Jan de Vries, Hengchi Chen   +3 more
wiley   +1 more source

Table_1_Spectrum of Neurological Symptoms in Glycosylphosphatidylinositol Biosynthesis Defects: Systematic Review.DOCX

, 2022
Background: Mutations of genes involved in the synthesis of glycosylphosphatidylinositol and glycosylphosphatidylinositol-anchored proteins lead to rare syndromes called glycosylphosphatidylinositol-anchored proteins biosynthesis defects.
Jagoda Hofman (11897720), Aleksandra Jezela-Stanek (3862963), Robert Śmigiel (11715935), Magdalena Kłaniewska (11897726), Krzysztof Szczałuba (11897729), Agnieszka Tokarska (11897723), Agnieszka Stembalska (11897732), Michał Hutny (11897717), Justyna Paprocka (10713864)   +8 more
core   +1 more source

Clonal Dynamics of GPI‐Deficient Cells in Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH): A Retrospective Follow‐Up Analysis

European Journal of Haematology, Volume 117, Issue 6, Page 1583-1592, December 2026.
ABSTRACT This retrospective, single‐center study aimed to characterize clonal dynamics of GPI‐deficient cells in patients with paroxysmal nocturnal hemoglobinuria (PNH) or PNH/aplastic anemia (AA) syndrome using multiparameter flow cytometry including FLAER.
Sandra M. Frey, Friederike Poppenborg, Ute Schmücker, Nicole Preising, H. Christian Reinhardt, Alexander Röth, Ferras Alashkar   +6 more
wiley   +1 more source

TbGT8 is a bifunctional glycosyltransferase that elaborates N-linked glycans on a protein phosphatase AcP115 and a GPI-anchor modifying glycan in Trypanosoma brucei [PDF]

, 2014
The procyclic form of Trypanosoma brucei expresses procyclin surface glycoproteins with unusual glycosylphosphatidylinositol-anchor side chain structures that contain branched N-acetyllactosamine and lacto-N-biose units.
Hashida, Kazunori, Nakanishi, Masayuki, Karasudani, Moe, Nomoto, Hiroshi, Hino, Mami, Ferguson, Michael A. J; id_orcid, Shiraishi, Takahiro   +6 more
core   +1 more source

Chemical Synthesis of 6-Azido-6-Deoxy Derivatives of Phosphatidylinositol Containing Different Fatty Acid Chains

Molecules
This paper describes the synthesis of two 6-azido-6-deoxy derivatives of phosphatidylinositol (PI), which contained different fatty acid chains. These syntheses, starting from methyl α-d-glucopyranoside, employed multiple regioselective transformations ...
Mosidur Rahaman Molla, Palak Gupta, Rajendra Rohokale, Zhongwu Guo   +3 more
doaj   +1 more source