Results 61 to 70 of about 29,448 (207)

A Woman With Hypertriglyceridemia Who Acquired Antibody Against GPIHBP1

JACC: Case Reports, 2020
We report a case of a woman with primary hypertriglyceridemia caused by acquired glycosylphosphatidylinositol-anchored high-density lipoprotein binding protein 1 (GPIHBP1) autoantibody. This case highlights the necessity of detecting GPIHBP1 autoantibody
Yuka Hirano, MD, Yasunori Suematsu, MD, PhD, Yuiko Yano, MD, PhD, Shuichi Sato, MD, PhD, Shin-Ichiro Miura, MD, PhD   +4 more
doaj   +1 more source

Deletions in CWH43 cause idiopathic normal pressure hydrocephalus

EMBO Molecular Medicine, 2021
Idiopathic normal pressure hydrocephalus (iNPH) is a neurological disorder that occurs in about 1% of individuals over age 60 and is characterized by enlarged cerebral ventricles, gait difficulty, incontinence, and cognitive decline.
Hong Wei Yang, Semin Lee, Dejun Yang, Huijun Dai, Yan Zhang, Lei Han, Sijun Zhao, Shuo Zhang, Yan Ma, Marciana F Johnson, Anna K Rattray, Tatyana A Johnson, George Wang, Shaokuan Zheng, Rona S Carroll, Peter J Park, Mark D Johnson   +16 more
doaj   +1 more source

Interaction with NEGR1 affects mGlu5 cell signalling and the neuroprotection induced by the positive allosteric modulator VU0409551

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose The metabotropic glutamate receptor mGlu5 plays an important role in neuronal survival and synaptic plasticity. We and others have shown that mGlu5 positive allosteric modulators (PAMs) are biased agonists, triggering the activation of neuroprotective pathways and promoting neuronal survival. As mGlu5 biased pharmacology
Jennifer D. S. Guimaraes, Toniana G. Carvalho, Luan A. Pereira, Emanuele G. Silva, Esther M. A. Maciel, Gabriella P. Torres, Thiago Assis, Pablo L. Cardozo, Joao P. P. de Almeida, Nathalia C. Silva, Francesca Pischedda, Giovanni Piccoli, Luciene B. Vieira, Juliana Alves‐Silva, Fabiola M. Ribeiro   +14 more
wiley   +1 more source

1,10-Phenanthroline Inhibits Glycosylphosphatidylinositol Anchoring by Preventing Phosphoethanolamine Addition to Glycosylphosphatidylinositol Anchor Precursors [PDF]

Biochemistry, 2001
The glycosylphosphatidylinositol (GPI) moiety is widely used to anchor a functionally diverse group of proteins to the plasma membrane of eukaryotes. In mammals, the predominant glycan structure of the GPI anchor consists of EthN-P-Man-Man-(EthN-P)Man-GlcN attached to an inositol phospholipid.
K J, Mann, D, Sevlever
openaire   +2 more sources

Synthesis of a Glycosylphosphatidylinositol Anchor Bearing Unsaturated Lipid Chains

, 2016
Synthesis of a Glycosylphosphatidylinositol Anchor Bearing Unsaturated Lipid ...
Benjamin M. Swarts (2298169), Zhongwu Guo (673969)   +1 more
core   +1 more source

Sugar activation and glycosylation in Plasmodium [PDF]

, 2015
TKS thanks previous funding from the Wellcome Trust (093228), SUSLA and BBSRC, and current funding from MRC (MR/M020118/1) and European Community’s Seventh Framework Programme under grant agreement No. 602773 (Project KINDRED). MC, JAR and LI are members
Smith, Terry K., Smith, Terry K, Izquierdo Lázaro, Luis, João A. Rodrigues, Rodrigues, João A., Cova, Marta, Marta Cova, Terry K. Smith, Izquierdo, Luis, Luis Izquierdo, Smith, Terry K; id_orcid   +10 more
core   +1 more source

Defining the boundaries of species specificity for the Saccharomyces cerevisiae glycosylphosphatidylinositol transamidase using a quantitative in vivo assay

Bioscience Reports, 2012
In eukaryotes, GPI (glycosylphosphatidylinositol) lipid anchoring of proteins is an abundant post-translational modification. The attachment of the GPI anchor is mediated by GPI-T (GPI transamidase), a multimeric, membrane-bound enzyme located in the ER (
Rachel Morissette, Yug Varma, Tamara L. Hendrickson   +2 more
doaj   +1 more source

Structures of liganded glycosylphosphatidylinositol transamidase illuminate GPI-AP biogenesis

Nature Communications, 2023
Many eukaryotic receptors and enzymes rely on glycosylphosphatidylinositol (GPI) anchors for membrane localization and function. The transmembrane complex GPI-T recognizes diverse proproteins at a signal peptide region that lacks consensus sequence and ...
Yidan Xu, Tingting Li, Zixuan Zhou, Jingjing Hong, Yulin Chao, Zhini Zhu, Ying Zhang, Qianhui Qu, Dianfan Li   +8 more
doaj   +1 more source

Genetic Susceptibility to Periodontitis

Journal of Periodontal Research, EarlyView.
Aim: The aim of this narrative review was to identify genes carrying risk alleles associated with an increased risk of periodontitis and to place them in a biological context. Methods: The literature was reviewed based on predefined criteria. Results: The identified genes largely fall into functions linking immune response with tissue repair. The genes
Gesa M. Richter, Arne S. Schaefer
wiley   +1 more source

Glycosylphosphatidylinositol Anchoring: Control through Modification [PDF]

PLANT PHYSIOLOGY, 2014
Glycosylphosphatidylinositol-anchor biosynthesis and glycosylphosphatidylinositol modification of proteins are central to coordinated plant development.
Alice Y, Cheung, Chao, Li, Yan-jiao, Zou, Hen-Ming, Wu   +3 more
openaire   +2 more sources