Results 1 to 10 of about 42,851 (291)

Type III Secretion Effectors with Arginine N-Glycosyltransferase Activity [PDF]

Microorganisms, 2020
Type III secretion systems are used by many Gram-negative bacterial pathogens to inject proteins, known as effectors, into the cytosol of host cells. These virulence factors interfere with a diverse array of host signal transduction pathways and cellular
Juan Luis Araujo-Garrido, Joaquín Bernal-Bayard, Francisco Ramos-Morales   +2 more
doaj   +3 more sources

The diverse N-glycosylation profiles of CD4+CD25- and CD4+CD25+ T cells in Hashimoto’s thyroiditis [PDF]

Frontiers in Immunology
Hashimoto’s thyroiditis (HT) is one of the most common organ-specific autoimmune diseases, characterized by chronic thyroid gland inflammation. Helper T (Th) CD4+ cells, whose surface receptors are highly glycosylated, are involved in the pathomechanism ...
Sara Trzos, Sara Trzos, Marta Szewczyk, Paweł Link-Lenczowski, Paweł Link-Lenczowski, Grzegorz Sokołowski, Małgorzata Trofimiuk-Müldner, Katarzyna Bocian, Ewa Pocheć   +8 more
doaj   +2 more sources

Glycosyltransferases: glycoengineers in human milk oligosaccharide synthesis and manufacturing [PDF]

Frontiers in Molecular Biosciences
Human milk oligosaccharides (HMOs) are a diverse group of complex carbohydrates that play crucial roles in infant health, promoting a beneficial gut microbiota, modulating immune responses, and protecting against pathogens.
Alanna S. Slater, Alanna S. Slater, Andrew G. McDonald, Rita M. Hickey, Gavin P. Davey   +4 more
doaj   +2 more sources

Functional Characterization of UDP-Glycosyltransferases Involved in Anti-viral Lignan Glycosides Biosynthesis in Isatis indigotica

Frontiers in Plant Science, 2022
Isatis indigotica is a popular herbal medicine with its noticeable antiviral properties, which are primarily due to its lignan glycosides such as lariciresinol-4-O-β-D-glucoside and lariciresinol-4,4′-bis-O-β-D-glucosides (also called clemastanin B). UDP-
Yuping Tan, Yuping Tan, Jian Yang, Yinyin Jiang, Jian Wang, Yahui Liu, Yujun Zhao, Baolong Jin, Xing Wang, Xing Wang, Tong Chen, Liping Kang, Juan Guo, Guanghong Cui, Jinfu Tang, Luqi Huang, Luqi Huang   +16 more
doaj   +1 more source

Family 1 glycosyltransferases (GT1, UGTs) are subject to dilution-induced inactivation and low chemo stability toward their own acceptor substrates

Frontiers in Molecular Biosciences, 2022
Glycosylation reactions are essential but challenging from a conventional chemistry standpoint. Conversely, they are biotechnologically feasible as glycosyltransferases can transfer sugar to an acceptor with perfect regio- and stereo-selectivity ...
David Teze, Gonzalo Nahuel Bidart, Ditte Hededam Welner   +2 more
doaj   +1 more source

Transgenic Overexpression of LARGE Induces alpha-Dystroglycan Hyperglycosylation in Skeletal and Cardiac Muscle [PDF]

, 2010
Background: LARGE is one of seven putative or demonstrated glycosyltransferase enzymes defective in a common group of muscular dystrophies with reduced glycosylation of alpha-dystroglycan.
Brockington, M, Brown, SC, Cirak, S, Liu, K, Muntoni, F, Sharp, PS, Torelli, S, Wells, DJ   +7 more
core   +20 more sources

Glycan synthesis with SpyCatcher-SpyTag immobilized Leloir-glycosyltransferases. [PDF]

Appl Microbiol Biotechnol
Palm P, Hussnaetter KP, Elling L.
europepmc   +3 more sources

Cracking the “Sugar Code”: A Snapshot of N- and O-Glycosylation Pathways and Functions in Plants Cells

Frontiers in Plant Science, 2021
Glycosylation is a fundamental co-translational and/or post-translational modification process where an attachment of sugars onto either proteins or lipids can alter their biological function, subcellular location and modulate the development and ...
Richard Strasser, Georg Seifert, Monika S. Doblin, Monika S. Doblin, Kim L. Johnson, Kim L. Johnson, Colin Ruprecht, Fabian Pfrengle, Antony Bacic, Antony Bacic, José M. Estevez, José M. Estevez, José M. Estevez   +12 more
doaj   +1 more source

Selectins—The Two Dr. Jekyll and Mr. Hyde Faces of Adhesion Molecules—A Review

Molecules, 2020
Selectins belong to a group of adhesion molecules that fulfill an essential role in immune and inflammatory responses and tissue healing. Selectins are glycoproteins that decode the information carried by glycan structures, and non-covalent interactions ...
Igor Tvaroška, Chandrabose Selvaraj, Jaroslav Koča   +2 more
doaj   +1 more source

Glycobiology of Cancer: Sugar Drives the Show

Medicines, 2022
Cancer development and progression is associated with aberrant changes in cellular glycosylation. Cells expressing altered glycan-structures are recognized by cells of the immune system, favoring the induction of inhibitory immune processes which ...
Jhenifer Santos dos Reis, Marcos André Rodrigues da Costa Santos, Daniella Pereira Mendonça, Stefani Ingrid Martins do Nascimento, Pedro Marçal Barcelos, Rafaela Gomes Correia de Lima, Kelli Monteiro da Costa, Celio Geraldo Freire-de-Lima, Alexandre Morrot, Jose Osvaldo Previato, Lucia Mendonça Previato, Leonardo Marques da Fonseca, Leonardo Freire-de-Lima   +12 more
doaj   +1 more source