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Current Opinion in Plant Biology, 2001
Glycosyltransferases are involved in the biosyntheses of cell-wall polysaccharides, the addition of N-linked glycans to glycoproteins, and the attachment of sugar moieties to various small molecules such as hormones and flavonoids. In the past two years, substantial progress has been made in the identification and cloning of genes that encode ...
Kenneth Keegstra
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Glycosyltransferases are involved in the biosyntheses of cell-wall polysaccharides, the addition of N-linked glycans to glycoproteins, and the attachment of sugar moieties to various small molecules such as hormones and flavonoids. In the past two years, substantial progress has been made in the identification and cloning of genes that encode ...
Kenneth Keegstra
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Glycosyltransferases and their Assays
ChemBioChem, 2010AbstractGlycosyltransferases (GTs) are a large family of enzymes that are essential in all domains of life for the biosynthesis of complex carbohydrates and glycoconjugates. GTs catalyse the transfer of a sugar from a glycosyl donor to a variety of acceptor molecules, for example, oligosaccharides, peptides, lipids or small molecules.
Gerd K Wagner, Thomas Pesnot
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Leloir Glycosyltransferases as Biocatalysts for Chemical Production
ACS Catalysis, 2018 Glycosylation is a chemical transformation that is centrally important in all glycoscience and related technologies. Catalysts offering good control over reactivity and selectivity in synthetic glycosylations are much sought.
Bernd Nidetzky +2 more
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Glycosyltransferases in Cancer: Prognostic Biomarkers of Survival in Patient Cohorts and Impact on Malignancy in Experimental Models [PDF]
Cancers, 2022 Background: Glycosylation changes are a main feature of cancer. Some carbohydrate epitopes and expression levels of glycosyltransferases have been used or proposed as prognostic markers, while many experimental works have investigated the role of ...
Michela Pucci +2 more
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Antibiotic glycosyltransferases
Biochemical Society Transactions, 2003In the biosynthesis of several classes of antibiotics, sugars are attached to aglycone scaffolds by antibiotic-specific glycosyltransferases in the latter stages of the pathways. Two glycosylation pathways will be examined: the glycopeptide antibiotics of the vancomycin class and the aminocoumarin antibiotics of the novobiocin class.
C T, Walsh +2 more
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Glycoconjugate glycosyltransferases
Glycoconjugate Journal, 2008Assay methods for representative glycosyltransferases were described, covering those involved in the synthesis of glycosphingolipids, N-glycans, O-glycans, and proteoglycan glycosaminoglycans. In addition, intracellular localization of glycosyltransferase was comprehensively summarized.
Koichi, Furukawa +3 more
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GLYCOSYLTRANSFERASES IN OLIGOSACCHARIDE SYNTHESIS
Journal of Carbohydrate Chemistry, 2001AbstractFor Abstract see ChemInform Abstract in Full Text.
Xiangping Qiam +3 more
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Iminosugars as glycosyltransferase inhibitors
Organic & Biomolecular Chemistry, 2021The review describes the syntheses and inhibition properties of pyrrolidine, piperidine, azepane, pyrrolizidine and indolizidine iminosugars, as well as iminosugar nucleotides and iminodi- and -oligosaccharides.
Irene Conforti, Alberto Marra
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Glycosyltransferases as biocatalysts
Current Opinion in Chemical Biology, 2011Glycosyltransferases are useful synthetic tools for the preparation of natural oligosaccharides, glycoconjugates and their analogues. High expression levels of recombinant enzymes have allowed their use in multi-step reactions, on mg to multi-gram scales.
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