Frontiers in Immunology, 2023 IntroductionEndogenous granulocyte-macrophage colony-stimulating factor (GM-CSF), identified by its ability to support differentiation of hematopoietic cells into several types of myeloid cells, is now known to support maturation and maintain the ...
Hillard M. Lazarus +15 more
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Adverse prognosis of GM-CSF expression in human cutaneous melanoma [PDF]
Neoplasia: An International Journal for Oncology ResearchBackground: GM-CSF, a myeloid-priming cytokine, exhibits context-dependent effects on tumor growth and, despite its clinical use, its role in human melanoma remains undefined.
Elena García-Martínez +8 more
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GM-CSF production by immune cells in steady state and autoimmune neuroinflammation mapped using fate reporting mice [PDF]
Frontiers in ImmunologyIntroductionGM-CSF is a pro-inflammatory cytokine that promotes an inflammatory phenotype in myeloid cells. The extent and pattern of GM-CSF expression in immune cells have not been fully elucidated.
Gholamreza Azizi +7 more
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Siglec-15 antibody–GM-CSF chimera suppresses tumor progression via reprogramming tumor-associated macrophages [PDF]
Journal for ImmunoTherapy of CancerBackground Sialic acid-binding immunoglobulin-like lectin (Siglec)-15-expressing tumor-associated macrophages (TAMs) drive immunosuppression in the tumor microenvironment (TME), promoting CD8+ T cell exhaustion and limiting immunotherapy efficacy.
Jun Li +12 more
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GM-CSF engages multiple signaling pathways to enhance pro-inflammatory cytokine responses in human monocytes during Legionella infection [PDF]
Infection and ImmunityThe proinflammatory cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF) is required for host defense against a wide range of pathogens. During infection with the intracellular bacterial pathogen Legionella pneumophila, we previously found ...
Víctor R. Vázquez Marrero +4 more
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The effect of GM-CSF and predictors of treatment outcome in pediatric septic shock patients [PDF]
Italian Journal of PediatricsBackground Pediatric septic shock is a critical condition associated with high mortality rates, largely due to sepsis-induced immunosuppression. Granulocyte-macrophage colony-stimulating factor (GM-CSF) has been explored as a therapeutic intervention to ...
Zhen-Hao Yu +9 more
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Chimeric HIV-1 envelope glycoproteins with potent intrinsic granulocyte-macrophage colony-stimulating factor (GM-CSF) activity. [PDF]
PLoS ONE, 2013 HIV-1 acquisition can be prevented by broadly neutralizing antibodies (BrNAbs) that target the envelope glycoprotein complex (Env). An ideal vaccine should therefore be able to induce BrNAbs that can provide immunity over a prolonged period of time, but ...
Gözde Isik +5 more
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Frontiers in Immunology, 2022 GM-CSF is an important cytokine that regulates the proliferation of monocytes/macrophages and its various functions during health and disease. Although growing evidences support the notion that GM-CSF could play a major role in immunity against ...
Abhishek Mishra +6 more
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Dense GM-CSFRα-expressing immune infiltration is allied with longer survival of intrahepatic cholangiocarcinoma patients [PDF]
PeerJ, 2023 Background Intrahepatic cholangiocarcinoma (iCCA) is a cancer arising from intrahepatic bile duct epithelium. An iCCA incidence is increasing worldwide; however, the outcome of the disease is dismal.
Paksiree Saranaruk +9 more
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Indian Journal of Transplantation, 2021 Introduction: Hemorrhagic cystitis (HC) is a well-known complication in patients undergoing hematopoeitic stem cell transplantation (HSCT), contributing considerably to morbidity and prolonged hospital stay.
Akanksha Garg +4 more
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