Results 141 to 150 of about 332,782 (345)

Porcine kidney xenotransplantation: From primate models to clinical reality

Animal Models and Experimental Medicine, EarlyView.
In the face of a critical shortage of human donor kidneys for end‐stage renal disease patients, porcine kidney xenotransplantation has emerged as a viable solution. This field has navigated major hurdles, including immune rejection, physiological incompatibilities, potential biomechanical differences and the risk of cross‐species infection. To overcome
Zihang Guo, Ling Zhang, Shoulong Deng, Chuan Qin   +3 more
wiley   +1 more source

IL-3 and GM-CSF in combination alters protein tyrosine kinase activity of splenic macrophages in leukemic mice.

, 2015
Ashish Kumar Singha, Bhaskar Bhattacharjee, Debasish Maiti   +2 more
openalex   +1 more source

The HCMV‐encoded miR‐UL36‐3p promotes angiogenesis of endothelial cells by downregulating FOXO3

Animal Models and Experimental Medicine, EarlyView.
This illustration shows the role of hcmv‐miR‐UL36‐3p in endothelial cell angiogenesis. During productive infection, endothelial cells express HCMV‐encoded miRNAs. Viral hcmv‐miR‐UL36‐3p promotes endothelial cell proliferation, migration, and capillary tube formation by directly targeting and downregulating FOXO3. The pro‐angiogenic activity of hcmv‐miR‐
Chen Wang, Mengyu Li, Guosheng Li, Hao Zhang, Cheng Wang, Chen‐Yu Zhang   +5 more
wiley   +1 more source

Humanized immune system animal models and their recent applications

Animal Models and Experimental Medicine, EarlyView.
In this review, we provide an updated and comprehensive overview of the current state of humanized immune system animal model research. We discuss the variety of techniques used to produce humanized mice with their respective strengths and weaknesses, and evaluate the advantages and limitations of these models, including issues with incomplete immune ...
Nicolas Skuli, Rudra B. Amin, A’ishah Bakayoko, Marisa Kruidenier, Sahara Aqui, Sarah J. Skuli, Terence P. Gade   +6 more
wiley   +1 more source

Data_Sheet_1_SV-BR-1-GM, a Clinically Effective GM-CSF-Secreting Breast Cancer Cell Line, Expresses an Immune Signature and Directly Activates CD4+ T Lymphocytes.XLSX

, 2018
Targeted cancer immunotherapy with irradiated, granulocyte–macrophage colony-stimulating factor (GM-CSF)-secreting, allogeneic cancer cell lines has been an effective approach to reduce tumor burden in several patients. It is generally assumed that to be
Sanne Graeve (5217185), Charles L. Wiseman (5217191), Markus D. Lacher (5217179), Tye D. Petrie (5217176), Ying Y. Kong (763600), Joseph P. Wagner (5217188), William W. Kwok (252537), Brian Fury (5217170), Tia Hackett (5217167), Dane P. Coleal-Bergum (5217173), William V. Williams (4376713), Emily L. Fledderman (2253685), Gerhard Bauer (748887), Nicholas H. Perotti (5217182)   +13 more
core   +1 more source

Anti-GD2 Monoclonal Antibody (dinutuximab) with GM-CSF, Interleukin 2, and Cis-retinoic Acid for the Treatment of High-risk Neuroblastoma

, 2016
In Sang Jeon
openalex   +1 more source

Dose‐dependent pathogenicity and inflammatory imbalance in severely immunodeficient mice infected with mpox virus

Animal Models and Experimental Medicine, EarlyView.
This study establishes an NPG (NOD.Cg‐Prkdcscid Il2rgtm1/Vst) mouse model for severe monkeypox virus infection in immunocompromised hosts, demonstrating dose‐dependent disease severity and revealing that unbalanced pro‐inflammatory cytokine release drives pathogenesis, providing insights for therapeutic interventions. Abstract The global spread of mpox
Na Li, Ziqing Jia, Zhe Cong, Jianrong Ma, Jiahan Lu, Yongzhi Hou, Fei Wang, Jiasen Yang, Ting Chen, Jingjing Zhang, Dong Zhang, Jing Xue   +11 more
wiley   +1 more source

Data_Sheet_4_SV-BR-1-GM, a Clinically Effective GM-CSF-Secreting Breast Cancer Cell Line, Expresses an Immune Signature and Directly Activates CD4+ T Lymphocytes.XLSX

, 2018
Targeted cancer immunotherapy with irradiated, granulocyte–macrophage colony-stimulating factor (GM-CSF)-secreting, allogeneic cancer cell lines has been an effective approach to reduce tumor burden in several patients. It is generally assumed that to be
Sanne Graeve (5217185), Charles L. Wiseman (5217191), Markus D. Lacher (5217179), Tye D. Petrie (5217176), Ying Y. Kong (763600), Joseph P. Wagner (5217188), William W. Kwok (252537), Brian Fury (5217170), Tia Hackett (5217167), Dane P. Coleal-Bergum (5217173), William V. Williams (4376713), Emily L. Fledderman (2253685), Gerhard Bauer (748887), Nicholas H. Perotti (5217182)   +13 more
core   +1 more source

Hemophagocytosis exacerbated by G‐CSF/GM‐CSF treatment in a patient with myelodysplasia [PDF]

, 2004
Sa Wang, Barbara Degar, Arthur W. Zieske, Nelofar Shafi, Michal G. Rose   +4 more
openalex   +1 more source

Distinct osteoclastogenic potential of granulocyte-macrophage colony-stimulating factor-induced monocyte subsets

Bone Reports
Background: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovial inflammation and progressive bone destruction. Although osteoclasts mediate bone resorption in RA, recent evidence suggests that inflammatory osteoclasts ...
Shiho Kinoshita, Yasuhiro Omata, Kojiro Sato   +2 more
doaj   +1 more source