Results 11 to 20 of about 24,979 (220)

Pathophysiology of Ganglioside GM1 in Ischemic Stroke: Ganglioside GM1: A Critical Review [PDF]

Cell Transplantation, 2019
Ganglioside GM1 is a member of the ganglioside family which has been used in many countries and is thought of as a promising alternative treatment for preventing several neurological diseases, including cerebral ischemic injury. The therapeutic effects of GM1 have been proved both in neonates and in adults following ischemic brain damage; however, its ...
Zhang, Wenchao, Krafft, Paul R., Wang, Tianlong, Zhang, John H., Li, Li, Tang, Jiping   +5 more
openaire   +5 more sources

A Decoy-Receptor-Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration. [PDF]

Adv Sci (Weinh)
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Li F, Zhang B, Zhang Z, Zheng B, Han L, Yan C, Li J, Sun K, Zhao T, Shi J.   +9 more
europepmc   +2 more sources

Membrane Complexity and Phase Behavior Dictate the Stability of Membrane-Inserted Aβ₄₂ Hexamers. [PDF]

Chemphyschem
Neuronal membrane order and the specific interplay of constituent lipids modulate the structural stability of Aβ(1–42) hexamers. This lipid environment facilitates the stabilization of a transmembrane β‐barrel conformation, providing a molecular basis for understanding how membrane composition influences the formation of stable amyloid pores in ...
Bundschuh BF, Kley F, Wang Y, Strodel B.
europepmc   +2 more sources

The Ganglioside Gm1 In Mammalian Sperm Function [PDF]

, 2010
GM1 is known to influence several signaling pathways in somatic cells that are also important in sperm functional maturation, such as “capacitation” and fertilization.
Buttke, Danielle
core   +6 more sources

LDL-conjugated to GM1 micelles incorporating anticancer drugs to improve tumor cell uptake [PDF]

Nanomedicine Journal, 2021
Objective(s): The role of lipoproteins (LDL) as active molecules with preferential tumor interaction, but limited drug delivery capacity, has been previously reported.
Ariel Gustavo Garro, Roxana Valeria Alasino, Victoria Leonhard, Valeria Heredia, Dante Miguel Beltramo   +4 more
doaj   +1 more source

Host Factors Determine Anti-GM1 Response Following Oral Challenge of Chickens with Guillain-Barre Syndrome Derived Campylobacter jejuni Strain GB11 [PDF]

, 2010
Background: Anti-ganglioside antibodies with a pathogenic potential are present in C. jejuni-associated Guillain-Barre syndrome (GBS) patients and are probably induced by molecular mimicry.
Dijkstra, J.R. (Jeroen), LS Klinisch Onderzoek Wagenaar, Endtz, Hubert Ph, Ang, CW (Wim), Hubert Ph Endtz, Wagenaar, J.A., Jeurissen, Suzan H M, de Klerk, M.A., Jacobs Bart C., van Doorn, Pieter; id_orcid, Endtz Hubert Ph., Jacobs, B.C. (Bart), Endtz, Hubert, Klerk, M.A. de, Bart C Jacobs, van Doorn Pieter A., Dijkstra Jeroen R., Klerk, M.A., de, Jeurissen, P.P.T. (Patrick), Wagenaar Jaap A., de Klerk, MA, Ang, C.W., Jeurissen, SHM, Doorn, P.A., Marcel A de Klerk, Wagenaar, J.A. (Jaap), Endtz, H.P., Doorn, P.A. (Pieter) van, Doorn, P.A. van, Jacobs, B.C., Ang C. Wim, de Klerk Marcel A., Suzan H M Jeurissen, Dijkstra, JR, van Doorn, P.A., Dijkstra, J.R., Jaap A Wagenaar, Ang, C Wim, Dijkstra, Jeroen R, Wagenaar, JA, Jacobs, Bart C, Jeurissen, S.H.M., C Wim Ang, Jeroen R Dijkstra, Endtz, H.P. (Hubert), Wagenaar, Jaap A, de Klerk, Marcel A, Pieter A van Doorn, Ang, C.W. (Wim), van Doorn, Pieter A, Jeurissen Suzan H. M.   +50 more
core   +3 more sources

Preparation of Ganglioside GM1 by Supercritical CO₂ Extraction and Immobilized Sialidase

Molecules, 2019
Monosialotetrahexosylganglioside (GM1) has good activity on brain diseases and was developed to be a drug applied in clinics for neurological disorders and nerve injury. It is difficult to isolate GM1 in industry scale from the brains directly.
Li Ji, Zhonghui Qiao, Xin Zhang, Xiaolei Cheng, Weiyang Wang, Fan Zhang, Yifa Zhou, Ye Yuan   +7 more
doaj   +1 more source

AAV-mediated gene delivery in adult GM1-gangliosidosis mice corrects lysosomal storage in CNS and improves survival. [PDF]

PLoS ONE, 2010
GM1-gangliosidosis is a glycosphingolipid (GSL) lysosomal storage disease caused by a genetic deficiency of acid β-galactosidase (βgal), which results in the accumulation of GM1-ganglioside and its asialo-form (GA1) primarily in the CNS.
Rena C Baek, Marike L D Broekman, Stanley G Leroy, Laryssa A Tierney, Michael A Sandberg, Alessandra d'Azzo, Thomas N Seyfried, Miguel Sena-Esteves   +7 more
doaj   +1 more source

GM1 ganglioside exerts protective effects against glutamate‐excitotoxicity via its oligosaccharide in wild‐type and amyotrophic lateral sclerosis motor neurons

FEBS Open Bio, 2023
Alterations in glycosphingolipid metabolism have been linked to the pathophysiological mechanisms of amyotrophic lateral sclerosis (ALS), a neurodegenerative disease affecting motor neurons.
Giulia Lunghi, Erika Di Biase, Emma Veronica Carsana, Alexandre Henriques, Noelle Callizot, Laura Mauri, Maria Grazia Ciampa, Luigi Mari, Nicoletta Loberto, Massimo Aureli, Sandro Sonnino, Michael Spedding, Elena Chiricozzi, Maria Fazzari   +13 more
doaj   +1 more source

Ganglioside GM1 Targets Astrocytes to Stimulate Cerebral Energy Metabolism

Frontiers in Pharmacology, 2021
Gangliosides are major constituents of the plasma membrane and are known to promote a number of physiological actions in the brain, including synaptic plasticity and neuroprotection.
Charles Finsterwald, Sara Dias, Pierre J. Magistretti, Sylvain Lengacher   +3 more
doaj   +1 more source