Results 41 to 50 of about 24,979 (220)

ANXA2+ Small Extracellular Vesicles Drive Chemoresistance in Anaplastic Thyroid Cancer by Promoting XRCC5 Lactylation and Enhancing Non‐Homologous End‐Joining Repair

Advanced Science, EarlyView.
ANXA2+ sEVs promote cisplatin resistance in ATC by stabilizing the SRC/LDHA interaction, increasing LDHA phosphorylation and activity, and lactate production. Elevated lactate levels promote KAT5‐mediated lactylation of XRCC5 at lysine 265, enhancing its binding to XRCC6.
Shanshan Su, YiShan Xiong, Yuxuan Liang, Xiang Min, Daofeng Dai   +4 more
wiley   +1 more source

Characterization of GM1-Glc-immobilized fluorescent nanoparticles (GM1-Glc-SFNPs).

, 2015
(A) UV-Vis (dotted line) and fluorescence (solid line) spectra of GM1-Glc-SFNPs. (B) Dynamic light scattering measurement of GM1-Glc-SFNPs. The average hydrodynamic diameter was 8.9 nm. (C) MALDI-TOF MS analysis of GM1-Glc-SFNPs.
Nobuhiro Yuki (60770), Yasuo Suda (150967), Koichi Hirata (52794), Masahiro Wakao (256149), Hiroyuki Shinchi (797026), Hideharu Ishida (797027)   +5 more
core   +1 more source

GM1 neurotrophic properties are related to GM1 oligosaccharide - TRKA interaction.

, 2017
Several data suggest a specific role of ganglioside GM1 in neuronal differentiation and development, but the molecular mechanisms of these processes are largely unknown.
M. Aureli, D..Y. Pome', M. Maggioni, E. Chiricozzi, E. Di Biase, S. Sonnino   +5 more
core   +2 more sources

Cholesterol accelerates the binding of Alzheimer’s beta-amyloid peptide to ganglioside GM1 through a universal hydrogen-bond-dependent sterol tuning of glycolipid conformation.

Frontiers in Physiology, 2013
Age-related alterations of membrane lipids in brain cell membranes together with high blood cholesterol are considered as major risk factors for Alzheimer’s disease. Yet the molecular mechanisms by which these factors increase Alzheimer’s risk are mostly
Jacques eFantini, Nouara eYahi, Nicolas eGarmy   +2 more
doaj   +1 more source

Burden of caregiving of individuals with GM1 and GM2 gangliosidoses in the United States: a qualitative study

Orphanet Journal of Rare Diseases
Background GM1 and GM2 (Tay–Sachs and Sandhoff diseases) gangliosidoses are rare, autosomal recessive, potentially life-threatening, disabling disorders characterized by progressive neurodegeneration, with no disease-modifying treatment. This qualitative
Maria Belen Rodriguez, Ruth Pulikottil-Jacob, Karli Heuer, Nancy Gabriela Perez, Christine Waggoner, Diana Jussila, Chad Gwaltney, Robert Krupnick, Daisy Ng-Mak   +8 more
doaj   +1 more source

Untersuchung von Anti‐Glykan‐Antikörpern und Erforschung ihres medizinischen Potenzials mithilfe synthetischer Glykane

Angewandte Chemie, EarlyView.
Anti‐Glykan‐Antikörper spielen sowohl bei Gesundheit als auch bei Krankheit eine wesentliche Rolle. Der Zugang zu neuartigen Glykanstrukturen ermöglicht Fortschritte bei der Antikörpercharakterisierung für die Entdeckung von Biomarkern, die Antikörperentwicklung und das Impfstoffdesign.
Fabienne Weber, Aina Valenti, Jiří Ledvinka, Oren Moscovitz, Peter H. Seeberger   +4 more
wiley   +1 more source

GM1 complex antigens.

, 2013
(A) Individual value plots for selected antigens. (B) Association between sulfatide:GM1 and GM1 binding intensities in individual sera. Points on the y-axis are GM1 negative, sulfatide:GM1 positive. Sera close to the diagonal blue line (joining points of
Gabriela Kalna (192504), Bart C. Jacobs (139863), Carl S. Goodyear (176375), Kathryn M. Brennan (497905), Pieter van Doorn (497907), Jan-Eric Mansson (5652196), Simon Rinaldi (497904), Hugh J. Willison (139850), Christa Walgaard (497906), Robert K. Yu (337438)   +9 more
core   +1 more source

Ganglioside-monosialic acid (GM1) for prevention of chemotherapy-induced peripheral neuropathy: a meta-analysis with trial sequential analysis

BMC Cancer, 2021
Background Chemotherapy-induced peripheral neuropathy (CIPN) is a dose-limiting side effect that largely remains an unresolved clinical issue, leading to long-term morbidity.
Shaoyong Wu, Xiaohui Bai, Caixia Guo, Zhimei Huang, Handong Ouyang, Jingxiu Huang, Weian Zeng   +6 more
doaj   +1 more source

The Ganglioside Monosialotetrahexosylganglioside Protects Auditory Hair Cells Against Neomycin-Induced Cytotoxicity Through Mitochondrial Antioxidation: An in vitro Study

Frontiers in Cellular Neuroscience, 2021
Neomycin is a common ototoxic aminoglycoside antibiotic that causes sensory hearing disorders worldwide, and monosialotetrahexosylganglioside (GM1) is reported to have antioxidant effects that protect various cells.
Yujin Li, Yujin Li, Ao Li, Ao Li, Ao Li, Chao Wang, Xin Jin, Yaoting Zhang, Ling Lu, Ling Lu, Ling Lu, Shou-Lin Wang, Xia Gao, Xia Gao, Xia Gao   +14 more
doaj   +1 more source

Using Synthetic Glycans to Investigate Anti‐Glycan Antibodies and Explore Their Medical Potential

Angewandte Chemie International Edition, EarlyView.
Anti‐glycan antibodies are essential in health and disease. Access to novel glycan structures paves the way for progress in antibody profiling for biomarker discovery, antibody development, and vaccine design. We summarize the strategies to synthesize and utilize synthetic glycans for the development and application of anti‐glycan antibodies in basic ...
Fabienne Weber, Aina Valenti, Jiří Ledvinka, Oren Moscovitz, Peter H. Seeberger   +4 more
wiley   +1 more source