Results 31 to 40 of about 24,979 (220)
Unexpected Conduction Blocks in <i>SORD</i>-Related Distal Motor Neuropathy: A Case Report. [PDF]
Clin Case RepABSTRACT Distal weakness requires an extensive differential diagnosis. In this case, conduction blocks indicated multifocal motor neuropathy, but immunotherapy proved ineffective. Ultimately, genetic testing revealed a sorbitol dehydrogenase mutation, highlighting the importance of combining electrophysiological findings with molecular studies in cases
Bucur AA +7 more
europepmc +2 more sources
High-throughput imaging method for direct assessment of GM1 ganglioside levels in mammalian cells
Data in Brief, 2016 GM1-gangliosidosis is an inherited autosomal recessive disorder caused by mutations in the gene GLB1, which encodes acid β-galactosidase (β-gal). The lack of activity in this lysosomal enzyme leads to accumulation of GM1 gangliosides (GM1) in cells.
Walter Acosta +3 more
doaj +1 more source
Ceramide structure dictates glycosphingolipid nanodomain assembly and function
Nature Communications, 2021 Gangliosides such as GM1 present in the outer leaflet of the plasma membrane of eukaryotic cells are essential for many cellular functions and pathogenic interactions.
Senthil Arumugam +10 more
doaj +1 more source
GM1-Gangliosidosis Type III Associated Parkinsonism [PDF]
, 2021 GLB1 encodes beta-galactosidase-1, a lysosomal hydrolase that cleaves the terminal beta-galactose from ganglioside substrates. Biallelic variants in GLB1 cause beta-galactosidase deficiency leading to GM1 gangliosidosis.1 Type III GM1 gangliosidosis ...
Ferla, Matteo P +7 more
core +1 more source
Molecules, 2014 A new ganglioside transformed strain isolated from soil was identified as Cellulosimicrobium sp. 21. It produced a sialidase which transformed polysialo-gangliosides GD1 and GT1 into a monosialoterahexosylganglioside, i.e., ganglioside GM1. The sialidase
Yan Zheng +7 more
doaj +1 more source
GM1-Binding Conjugates To Improve Intestinal Permeability
, 2018 Drugs and proteins with poor intestinal permeability have a limited oral bioavailability. To remediate this problem, a receptor-mediated endocytosis and transcytosis approach was explored.
Isabelle St-Jean (6030425) +9 more
core +1 more source
Ganglioside GM1 influences the proliferation rate of mouse induced pluripotent stem cells [PDF]
BMB Reports, 2012 Gangliosides play important roles in the control of severalbiological processes, including proliferation and transmembranesignaling. In this study, we demonstrate the effect ofganglioside GM1 on the proliferation of mouse inducedpluripotent stem cells ...
Young-Kug Choo
doaj
Complex of GM1- and GD1a-like lipo-oligosaccharide mimics GM1b, inducing anti-GM1b antibodies. [PDF]
PLoS ONE, 2015 Molecular mimicry between Campylobacter jejuni lipo-oligosaccharides (LOSs) and human gangliosides GM1 and GD1a induces the production of anti-GM1 and anti-GD1a antibodies, and the development of Guillain-Barré syndrome.
Michiaki Koga +3 more
doaj +1 more source
Journal of Lipid Research, 1999 Dowex-50W-H+ was used to catalyze the highly selective desialylation of polysialylated ganglio-N-tetraose series gangliosides to yield primarily GM1. High performance thin-layer chromatographic analysis of recovered lipid indicated that 60–70% of the ...
Cara-Lynne Schengrund, Pavol Kováč
doaj +1 more source
Advanced Robotics Research, EarlyView.Rotating magnetic fields (RMFs) are widely used for microrobot propulsion and control. We show that RMF generation with permanent magnets is mechanically feasible for many limb and intracranial applications but becomes constrained for thoracic targets.
Tuan‐Anh Le +4 more
wiley +1 more source