Results 21 to 30 of about 24,979 (220)

Neu3 sialidase-mediated ganglioside conversion is necessary for axon regeneration and is blocked in CNS axons [PDF]

, 2014
This work was supported by the Medical Research Council, the Christopher and Dana Reeve Foundation, the John and Lucille van Geest Foundation, the Henry Smith Charity, the Commonwealth and Overseas scholarships, and the Hinduja Cambridge Trust.PNS axons ...
Cheah, Menghon, Dotti, Carlos G, Andrews, Melissa R., Andrews, Melissa Renee, Kappagantula, Sunil, Abad-Rodriguez, Jose', Abad-Rodriguez, José, Fawcett, James W   +7 more
core   +1 more source

Guillain-Barré Syndrome-related campylobacter jejuni in Bangladesh: ganglioside mimicry and cross-reactive antibodies [PDF]

, 2012
BACKGROUND: <br/> Campylobacter jejuni is the predominant antecedent infection in Guillain-Barré syndrome (GBS). Molecular mimicry and cross-reactive immune responses to C.
Klaij, K, Talukder, K.A. (Kaisar), Tio-Gillen, Anne P., Endtz Hubert P., Gilbert Michel, Klaij, K., Jianjun Li (139837), Anne P. Tio-Gillen (139842), Talukder, K.A., Gilbert, Michel, Klaij, Kevin, Kaisar A Talukder, Gillen, Anne, Islam, Zhahirul, Tio-Gillen Anne P., Quazi D Mohammad, Talukder, KA, Talukder, Kaisar A., Gilbert, M., van Rijs, W., Jacobs, Bart C., Alex van Belkum (38419), Hugh J Willison, Islam, Z. (Zhahirul), van Rijs, Wouter, Kevin Klaij, Jacobs Bart C., Willison, H.J. (Hugh), Quazi D. Mohammad (139834), Li, J. (Jianjun), Klaij Kevin, Talukder Kaisar A., Willison, HJ, Mohammad, Quazi D., Gilbert, M. (Michel), Klaij, K. (Kevin), Jacobs, B.C. (Bart), Bart C. Jacobs (139863), Endtz, Hubert, Jianjun Li, Bart C Jacobs, Li, J., Willison, Hugh J., Willison Hugh J., Kevin Klaij (139835), Rijs, Wouter, Zhahirul Islam, Tio-Gillen, A.P., Willison, H.J., Michel Gilbert (60775), Endtz, H.P., van Belkum Alex, Jacobs, B.C., Endtz, Hubert P., Mohammad, QD, van Belkum, Alex, Hugh J. Willison (139850), Mohammad Quazi D., van Rijs Wouter, Hubert P. Endtz (139857), Li, JJ, Michel Gilbert, Kaisar A. Talukder (139846), Mohammad, Q.D., Wouter van Rijs, Mohammad, Q.D. (Quazi), Zhahirul Islam (139833), Belkum, Alex, Hubert P Endtz, Gilbert, M, Belkum, A.F. (Alex) van, Islam Zhahirul, Islam, Z, Islam, Z., Tio-Gillen, A.P. (Anne), Endtz, H.P. (Hubert), Anne P Tio-Gillen, Wouter van Rijs (139839), Rijs, W. (Wouter) van, van Belkum, A., Li, Jianjun, Li Jianjun, Alex van Belkum   +82 more
core   +3 more sources

Preparation of lyso-GM1 (II3Neu5AcGgOse4-long chain bases) by a one-pot reaction.

Journal of Lipid Research, 1992
A simple procedure is described for preparing lyso-GM1, a GM1 derivative that lacks the fatty acid moiety, starting from GM1 ganglioside using a one-pot reaction. Ganglioside deacylation was carried out in KOH/propan-1-ol in the absence of oxygen.
S Sonnino, D Acquotti, G Kirschner, A Uguaglianza, L Zecca, F Rubino, G Tettamanti   +6 more
doaj   +1 more source

GM1 and GM2 gangliosides: recent developments

Biomolecular Concepts, 2014
GM1 and GM2 gangliosides are important components of the cell membrane and play an integral role in cell signaling and metabolism. In this conceptual overview, we discuss recent developments in our understanding of the basic biological functions of GM1 ...
Bisel Blaine, Pavone Francesco S., Calamai Martino   +2 more
doaj   +1 more source

Ingenious Action of Vibrio cholerae Neuraminidase Recruiting Additional GM1 Cholera Toxin Receptors for Primary Human Colon Epithelial Cells

Microorganisms, 2022
For five decades it has been known that the pentamer of B subunits (choleragenoid) of the cholera toxin (CT) of Vibrio cholerae binds with high preference to the ganglioside GM1 (II3Neu5Ac-Gg4Cer).
Johanna Detzner, Charlotte Püttmann, Gottfried Pohlentz, Johannes Müthing   +3 more
doaj   +1 more source

Preclinical Enzyme Replacement Therapy with a Recombinant β-Galactosidase-Lectin Fusion for CNS Delivery and Treatment of GM1-Gangliosidosis

Cells, 2022
GM1-gangliosidosis is a catastrophic, neurodegenerative lysosomal storage disease caused by a deficiency of lysosomal β-galactosidase (β-Gal). The primary substrate of the enzyme is GM1-ganglioside (GM1), a sialylated glycosphingolipid abundant in ...
Jason Andrew Weesner, Ida Annunziata, Tianhong Yang, Walter Acosta, Elida Gomero, Huimin Hu, Diantha van de Vlekkert, Jorge Ayala, Xiaohui Qiu, Leigh Ellen Fremuth, David N. Radin, Carole L. Cramer, Alessandra d’Azzo   +12 more
doaj   +1 more source

Synthetic GM1 improves motor and memory dysfunctions in mice with monoallelic or biallelic disruption of GM3 synthase

FEBS Open Bio, 2023
This study attempts to answer the question of whether mice with biallelic and monoallelic disruption of the St3gal5 (GM3 synthase) gene might benefit from GM1 replacement therapy.
Suman Chowdhury, Ranjeet Kumar, Evelyn Zepeda, Shawn DeFrees, Robert Ledeen   +4 more
doaj   +1 more source

Conformational Change of Amyloid-β 40 in Association with Binding to GM1-Glycan Cluster

Scientific Reports, 2019
Aggregates of amyloid-β (Aβ) peptide are well known to be the causative substance of Alzheimer’s disease (AD). Recent studies showed that monosialotetrahexosylganglioside (GM1) clusters induce the pathological aggregation of Aβ peptide responsible for ...
Yuhei Tachi, Yuko Okamoto, Hisashi Okumura   +2 more
doaj   +1 more source

Uptake and metabolism of exogenous gangliosides by cultured cells: effect of choleragen on the turnover of GM1.

Journal of Lipid Research, 1983
When added to the culture medium, 3H-labeled GM1 (tritiated predominantly in the terminal galactose residue) was taken up by murine NCTC 2071 and rat glioma C6 cells, both of which are GM1-deficient. Upon incubating the labeled cells in fresh medium, the
P H Fishman, R M Bradley, B E Hom, J Moss   +3 more
doaj   +1 more source

Anti-Inflammatory Effects of GM1 Ganglioside on Endotoxin-Induced Uveitis in Rats

Biomolecules, 2022
Exogenous ganglioside GM1 has been reported to exert an immunomodulatory effect. We investigated the anti-inflammatory effect of GM1 ganglioside on endotoxin-induced uveitis (EIU) in rats and RAW 264.7 macrophages.
Tzu-Heng Weng, Chang-Chih Ke, Yuahn-Sieh Huang   +2 more
doaj   +1 more source