Results 21 to 30 of about 44,908 (222)

Thermal evolution of hybrid stars within the framework of a nonlocal Nambu--Jona-Lasinio model [PDF]

, 2015
We study the thermal evolution of neutron stars containing deconfined quark matter in their core. Such objects are generally referred to as quark-hybrid stars.
Contrera, G. A., de Carvalho, S. M., Negreiros, R., Orsaria, M., Spinella, W., Weber, F.   +5 more
core   +2 more sources

Ingenious Action of Vibrio cholerae Neuraminidase Recruiting Additional GM1 Cholera Toxin Receptors for Primary Human Colon Epithelial Cells

Microorganisms, 2022
For five decades it has been known that the pentamer of B subunits (choleragenoid) of the cholera toxin (CT) of Vibrio cholerae binds with high preference to the ganglioside GM1 (II3Neu5Ac-Gg4Cer).
Johanna Detzner, Charlotte Püttmann, Gottfried Pohlentz, Johannes Müthing   +3 more
doaj   +1 more source

GM1 Gangliosidosis—A Mini-Review [PDF]

Frontiers in Genetics, 2021
GM1 gangliosidosis is a progressive, neurosomatic, lysosomal storage disorder caused by mutations in theGLB1gene encoding the enzyme β-galactosidase. Absent or reduced β-galactosidase activity leads to the accumulation of β-linked galactose-containing glycoconjugates including the glycosphingolipid (GSL) GM1-ganglioside in neuronal tissue.
Elena-Raluca Nicoli, Ida Annunziata, Alessandra d’Azzo, Alessandra d’Azzo, Frances M. Platt, Cynthia J. Tifft, Cynthia J. Tifft, Karolina M. Stepien, Karolina M. Stepien   +8 more
openaire   +3 more sources

Gravitational field and equations of motion of compact binaries to 5/2 post-Newtonian order [PDF]

, 1998
We derive the gravitational field and equations of motion of compact binary systems up to the 5/2 post-Newtonian approximation of general relativity (where radiation-reaction effects first appear). The approximate post-Newtonian gravitational field might
A. Sellier, Bénédicte Ponsot, C. Cutler, C. Cutler, C. Cutler, E. Poisson, E. Poisson, G. Schäfer, G. Schäfer, G. Schäfer, Guillaume Faye, H. Tagoshi, J. H. Taylor, J. H. Taylor, J. H. Taylor, K. Westpfahl, L. Bel, L. Blanchet, L. Blanchet, L. Blanchet, L. P. Grishchuk, L. S. Finn, Luc Blanchet, M. Carmeli, M. Riesz, M. Walker, P. Jaranowski, P. Jaranowski, P. Jaranowski, P. R. Brady, R. Estrada, S. M. Kopejkin, T. Damour, T. Damour, T. Damour, T. Damour, T. Damour, T. Damour, T. Damour, T. Ohta, T. Ohta, T. Ohta, T. Ohta   +42 more
core   +2 more sources

Synthetic GM1 improves motor and memory dysfunctions in mice with monoallelic or biallelic disruption of GM3 synthase

FEBS Open Bio, 2023
This study attempts to answer the question of whether mice with biallelic and monoallelic disruption of the St3gal5 (GM3 synthase) gene might benefit from GM1 replacement therapy.
Suman Chowdhury, Ranjeet Kumar, Evelyn Zepeda, Shawn DeFrees, Robert Ledeen   +4 more
doaj   +1 more source

Preclinical Enzyme Replacement Therapy with a Recombinant β-Galactosidase-Lectin Fusion for CNS Delivery and Treatment of GM1-Gangliosidosis

Cells, 2022
GM1-gangliosidosis is a catastrophic, neurodegenerative lysosomal storage disease caused by a deficiency of lysosomal β-galactosidase (β-Gal). The primary substrate of the enzyme is GM1-ganglioside (GM1), a sialylated glycosphingolipid abundant in ...
Jason Andrew Weesner, Ida Annunziata, Tianhong Yang, Walter Acosta, Elida Gomero, Huimin Hu, Diantha van de Vlekkert, Jorge Ayala, Xiaohui Qiu, Leigh Ellen Fremuth, David N. Radin, Carole L. Cramer, Alessandra d’Azzo   +12 more
doaj   +1 more source

C1q-targeted inhibition of the classical complement pathway prevents injury in a novel mouse model of acute motor axonal neuropathy [PDF]

, 2016
Introduction Guillain-Barré syndrome (GBS) is an autoimmune disease that results in acute paralysis through inflammatory attack on peripheral nerves, and currently has limited, non-specific treatment options.
Barrie, Jennifer A., Cunningham, Madeleine E., Fewou, Simon N., Furukawa, Koichi, McGonigal, Rhona, Sankaranarayanan, Sethu, Willison, Hugh J., Yao, Denggao, Yednock, Ted A.   +8 more
core   +2 more sources

Conformational Change of Amyloid-β 40 in Association with Binding to GM1-Glycan Cluster

Scientific Reports, 2019
Aggregates of amyloid-β (Aβ) peptide are well known to be the causative substance of Alzheimer’s disease (AD). Recent studies showed that monosialotetrahexosylganglioside (GM1) clusters induce the pathological aggregation of Aβ peptide responsible for ...
Yuhei Tachi, Yuko Okamoto, Hisashi Okumura   +2 more
doaj   +1 more source

Uptake and metabolism of exogenous gangliosides by cultured cells: effect of choleragen on the turnover of GM1.

Journal of Lipid Research, 1983
When added to the culture medium, 3H-labeled GM1 (tritiated predominantly in the terminal galactose residue) was taken up by murine NCTC 2071 and rat glioma C6 cells, both of which are GM1-deficient. Upon incubating the labeled cells in fresh medium, the
P H Fishman, R M Bradley, B E Hom, J Moss   +3 more
doaj   +1 more source

Hyperons in neutron star matter within relativistic mean-field models [PDF]

, 2014
Since the discovery of neutron stars with masses around 2 solar masses the composition of matter in the central part of these massive stars has been intensively discussed.
Gulminelli, F., Oertel, M., Providência, C., Raduta, A. R.   +3 more
core   +6 more sources