Results 61 to 70 of about 44,908 (222)

Quantifying Protein–Glycan Interactions Using Native Mass Spectrometry

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Interactions between glycan‐binding proteins (GBPs) and carbohydrates (glycans) are essential to many biological processes relevant to human health and disease. For most GBPs, however, their glycan interactome—the repertoire of glycans recognized and their specificities—is poorly defined.
Duong T. Bui, Elena N. Kitova, Ling Han, Lara K. Mahal, John S. Klassen   +4 more
wiley   +1 more source

SLPI/FBW7/c‐Myc Axis Reduces Gemcitabine Sensitivity in PDAC by Enhancing Glycolysis and Impairing NK Cell Immunity

Cancer Science, EarlyView.
SLPI reduces the sensitivity of PDAC to gemcitabine by competing with FBW7 for binding to c‐Myc, thereby disrupting FBW7‐dependent ubiquitination and proteasomal degradation of c‐Myc, leading to increased c‐Myc stability and expression. SLPI knockdown could significantly increase gemcitabine sensitivity to gemcitabine‐induced direct cytotoxicity and NK
Haofei Chen, Xin Li, Weixiong Zhu, Yanxi Mu, Guoqing Zhang, Youheng Zhang, Yusheng Cheng, Wence Zhou   +7 more
wiley   +1 more source

A Measurement of the K0 Charge Radius and a CP Violating Asymmetry Together with a Search for CP Violating E1 Direct Photon Emission in the Rare Decay KL->pi+pi-e+e-

, 2005
Using the complete KTeV data set of 5241 candidate KL->pi+pi-e+e- decays (including an estimated background of 204+-14 events), we have measured the coupling gCR=0.163+- 0.014(stat)+-0.023(syst) of the CP conserving charge radius process and from it ...
A. Bellavance, A. Glazov, A. Golossanov, A. Ledovskoy, A. R. Barker, A. R. Erwin, B. Cox, B. Winstein, C. O. Escobar, C. Velissaris, D. A. Jensen, D. Smith, E. Abouzaid, E. Blucher, E. C. Swallow, E. Cheu, E. D. Zimmerman, E. J. Ramberg, E. Monnier, E. Santos, E. T. Worchester, G. Corti, G. J. Bock, H. B. White, H. Foeth, H. Huang, H. Nguyen, H. Ping, J. Shields, J. Wang, J. Whitmore, K. Hanagaki, K. Kotera, K. S. Nelson, L. Bellantoni, M. Arenton, M. D. Corcoran, M. Ronquest, M. Wilking, M. Worchester, N. Solomey, P. A. Toale, P. Gouffon, P. L. McBride, R. A. Gomes, R. Coleman, R. E. Ray, R. F. Zukanovich, R. Kessler, R. Niclasen, R. Tschirhart, R. Winston, T. Yamanaka, W. Slater, X. R. Qi, Y. B. Hsiung, Y. W. Wah   +56 more
core   +1 more source

The electromagnetic form factors of the Omega in lattice QCD [PDF]

, 2010
We present results on the Omega baryon electromagnetic form factors using $N_f=2+1$ domain-wall fermion configurations for three pion masses in the range of about 350 to 300 MeV.
C. Alexandrou, C. Alexandrou, G. Koutsou, I. Montvay, J. W. Negele, T. Korzec, Y. Proestos   +6 more
core   +2 more sources

Lipidomic Evaluation of Feline Neurologic Disease after AAV Gene Therapy

Molecular Therapy: Methods & Clinical Development, 2017
GM1 gangliosidosis is a fatal lysosomal disorder, for which there is no effective treatment. Adeno-associated virus (AAV) gene therapy in GM1 cats has resulted in a greater than 6-fold increase in lifespan, with many cats remaining alive at >5.7 years of
Heather L. Gray-Edwards, Xuntian Jiang, Ashley N. Randle, Amanda R. Taylor, Taylor L. Voss, Aime K. Johnson, Victoria J. McCurdy, Miguel Sena-Esteves, Daniel S. Ory, Douglas R. Martin   +9 more
doaj   +1 more source

Is That a Threat? How Types of Stakeholder and Reputational Threat Matter for Gaining Influence in Regulatory Rulemaking

Regulation &Governance, EarlyView.
ABSTRACT This paper assesses what type of comments are most useful to what type of stakeholder in gaining influence during public consultations. Theoretically, the paper approaches stakeholders' consultation comments as reputational threats from key audiences that the agency needs to respond to.
Rik Joosen
wiley   +1 more source

The B subunit of Escherichia coli heat-labile toxin alters the development and antigen-presenting capacity of dendritic cells [PDF]

, 2015
Escherichia coli’s heat-labile enterotoxin (Etx) and its non-toxic B subunit (EtxB) have been characterized as adjuvants capable of enhancing T cell responses to co-administered antigen.
Griffiths, Kristin L., Hirst, Timothy R., Ji, Jing, Milburn, Peter J., O'Neill, Helen C.   +4 more
core   +1 more source

Dry Deposition Strategies for MALDI–MS Imaging: Principles, Advances and Emerging Applications

Analytical Science Advances, Volume 7, Issue 1, June 2026.
ABSTRACT Matrix‐assisted laser desorption/ionisation mass spectrometry imaging (MALDI–MSI) has become a pivotal tool in biomedical research, enabling untargeted, spatially resolved analysis of molecular species in complex biological tissues. Among the critical steps in MALDI–MSI workflows, matrix deposition significantly influences sensitivity, spatial
Toufik Mahamdi, Oscar Yanes
wiley   +1 more source

Altered GM1 catabolism affects NMDAR-mediated Ca2+ signaling at ER-PM junctions and increases synaptic spine formation in a GM1-gangliosidosis model

Cell Reports
Summary: Endoplasmic reticulum-plasma membrane (ER-PM) junctions mediate Ca2+ flux across neuronal membranes. The properties of these membrane contact sites are defined by their lipid content, but little attention has been given to glycosphingolipids ...
Jason A. Weesner, Ida Annunziata, Diantha van de Vlekkert, Camenzind G. Robinson, Yvan Campos, Ashutosh Mishra, Leigh E. Fremuth, Elida Gomero, Huimin Hu, Alessandra d’Azzo   +9 more
doaj   +1 more source

Decoupling polarization of the Golgi apparatus and GM1 in the plasma membrane.

PLoS ONE, 2013
Cell polarization is a process of coordinated cellular rearrangements that prepare the cell for migration. GM1 is synthesized in the Golgi apparatus and localized in membrane microdomains that appear at the leading edge of polarized cells, but the ...
Blaine Bisel, Martino Calamai, Francesco Vanzi, Francesco Saverio Pavone   +3 more
doaj   +1 more source