Results 61 to 70 of about 24,979 (220)

Wheat Wild Relatives and Modern Cultivars Differ for Salt Resistance in Terms of Morpho‐Physiological Traits

Journal of Plant Nutrition and Soil Science, EarlyView.
Wheat wild relatives are untapped genetic resources from salinity and drought hit areas. This study presents differential comparative morphophysiological responses of these species and modern wheat cultivars under saline conditions. Salt resistant species produce more shoot and root biomass under saline conditions through salt exclusion and/or tissue ...
Muhammad Saqib, Riya Raj, Michael Frei
wiley   +1 more source

Ganglioside GM1 and the Central Nervous System

, 2023
GM1 is one of the major glycosphingolipids (GSLs) on the cell surface in the central nervous system (CNS). Its expression level, distribution pattern, and lipid composition are dependent upon cell and tissue type, developmental stage, and disease state ...
Zhongwu Guo
core   +1 more source

Phase Partitioning of GM1 and Its Bodipy-Labeled Analog Determine Their Different Binding to Cholera Toxin

Frontiers in Physiology, 2017
Driven by interactions between lipids and proteins, biological membranes display lateral heterogeneity that manifests itself in a mosaic of liquid-ordered (Lo) or raft, and liquid-disordered (Ld) or non-raft domains with a wide range of different ...
Sami Rissanen, Michal Grzybek, Michal Grzybek, Adam Orłowski, Adam Orłowski, Tomasz Róg, Tomasz Róg, Oana Cramariuc, Ilya Levental, Christian Eggeling, Erdinc Sezgin, Ilpo Vattulainen, Ilpo Vattulainen, Ilpo Vattulainen   +13 more
doaj   +1 more source

Rare‐Variant Burden across Lysosomal Genes Implicates Sialylation and Ganglioside Metabolism in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Lysosomal dysfunction is central to Parkinson's disease (PD) pathogenesis, with GBA1 representing the strongest established genetic risk factor. Numerous other genes involved in lysosomal sphingolipid, glycosphingolipid, and ceramide metabolism have been proposed as contributors to PD, highlighting the need for genetic analyses ...
Konstantin Senkevich, Sitki Cem Parlar, Cloe Chantereault, Lang Liu, Eric Yu, Uladzislau Rudakou, Jamil Ahmad, Jennifer A. Ruskey, Farnaz Asayesh, Dan Spiegelman, Cheryl Waters, Oury Monchi, Yves Dauvilliers, Nicolas Dupré, Lior Greenbaum, Sharon Hassin‐Baer, Irina Miliukhina, Alla Timofeeva, Anton Emelyanov, Sofya Pchelina, Roy N. Alcalay, Ziv Gan‐Or   +21 more
wiley   +1 more source

Altered GM1 catabolism affects NMDAR-mediated Ca2+ signaling at ER-PM junctions and increases synaptic spine formation in a GM1-gangliosidosis model

Cell Reports
Summary: Endoplasmic reticulum-plasma membrane (ER-PM) junctions mediate Ca2+ flux across neuronal membranes. The properties of these membrane contact sites are defined by their lipid content, but little attention has been given to glycosphingolipids ...
Jason A. Weesner, Ida Annunziata, Diantha van de Vlekkert, Camenzind G. Robinson, Yvan Campos, Ashutosh Mishra, Leigh E. Fremuth, Elida Gomero, Huimin Hu, Alessandra d’Azzo   +9 more
doaj   +1 more source

Prevalence and Disability of Peripheral Neuropathy in Patients With Waldenström's Macroglobulinemia

European Journal of Haematology, EarlyView.
ABSTRACT Objectives Peripheral neuropathy (PN) is considered a frequent complication of Waldenström's macroglobulinemia (WM). Establishing a causal relationship between PN and WM is complicated by confounding factors such as age‐related axonal loss and diabetes. This scoping review aims to summarize the current evidence on WM‐associated PN with a focus
Morten Müller Aagaard, Kristoffer Nagy Skaastrup, Louise Sloth Kodal, Britt Stævnsbo Pedersen, Troels Hammer, John Vissing, Tina Dysgaard   +6 more
wiley   +1 more source

Gangliosidosis GM1: About a Clinical Case [PDF]

, 2015
La gangliosidosis GM1 es una enfermedad de depósito lisosomal en la cual se acumula gangliósido-GM1 y otros compuestos galactoconjugados. La enfermedad es secundaria a la deficiencia de β-galactosidasa, con una afectación multiorgánica, en que predominan 
Espinosa García, Eugenia, Londoño C., Juan Pablo, Echeverri Peña, Olga Yaneth, Ardila, Yudy Andrea, Barrera A., Luis Alejandro   +4 more
core   +1 more source

Decoupling polarization of the Golgi apparatus and GM1 in the plasma membrane.

PLoS ONE, 2013
Cell polarization is a process of coordinated cellular rearrangements that prepare the cell for migration. GM1 is synthesized in the Golgi apparatus and localized in membrane microdomains that appear at the leading edge of polarized cells, but the ...
Blaine Bisel, Martino Calamai, Francesco Vanzi, Francesco Saverio Pavone   +3 more
doaj   +1 more source

Oral Delivery of Bioencapsulated CTB‐Pro‐IGF‐1 Enhances Bone Regeneration in a Pre‐Clinical Rat Model of Jaw Osteoradionecrosis

Oral Diseases, EarlyView.
ABSTRACT Objective Head and neck cancer radiotherapy can lead to jaw osteoradionecrosis (ORN). There is currently no definitive treatment for ORN. The efficacy of a novel orally delivered aglycosylated IGF‐1 with an E‐peptide (CTB‐Pro‐IGF‐1), bioencapsulated in plant cells, was evaluated as therapy for jaw ORN in rats. Materials and Methods Rat jaw ORN
Sunday O. Akintoye, Arularasan Anbinselvam, Prasath Jeyaraman, Uddhab Karki, Geetanjali Wakade, Henry Daniell   +5 more
wiley   +1 more source

Agglutination assay of GM1-Glc-immobilized fluorescent nanoparticles (GM1-Glc-SFNPs) with sera from GBS patients.

, 2015
(A) Visual image of fluorescent aggregates under UV irradiation (samples 1 and 3: negative for anti-GM1/GD1a antibodies; sample 2: positive for anti-GD1a antibodies; samples 4, 5, and 6: positive for anti-GM1 IgG antibodies).
Nobuhiro Yuki (60770), Yasuo Suda (150967), Koichi Hirata (52794), Masahiro Wakao (256149), Hiroyuki Shinchi (797026), Hideharu Ishida (797027)   +5 more
core   +1 more source