Results 81 to 90 of about 24,979 (220)

The Role of Lipid Environment in Ganglioside GM1-Induced Amyloid β Aggregation

Membranes, 2020
Ganglioside GM1 is the most common brain ganglioside enriched in plasma membrane regions known as lipid rafts or membrane microdomains. GM1 participates in many modulatory and communication functions associated with the development, differentiation, and ...
Vladimir Rudajev, Jiri Novotny
doaj   +1 more source

Recent Advancements in Drug Delivery Across the Blood–Brain Barrier in Amyotrophic Lateral Sclerosis (ALS)

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
Progressive BBB/BSCB dysfunction is increasingly recognized as both a pathological feature and a therapeutic barrier in ALS. Novel delivery technologies and barrier‐restoration strategies may enhance CNS drug exposure, improve the efficacy of disease‐modifying therapies, and advance ALS treatment. ABSTRACT Background Amyotrophic lateral sclerosis (ALS)
Nitesh Sanghai, Kaitlyn Pierce, Nidhi Sharma, Sasha Leggett, Tara Chand Yadav, Pegah Masrori, Devi Atukorallaya, Senthilnathan Palaniyandi, Paul C. Marcogliese, Geoffrey K. Tranmer   +9 more
wiley   +1 more source

Influence of Ganglioside GM1 Concentration on Lipid Clustering and Membrane Properties and Curvature

, 2016
Gangliosides are a class of glycosphingolipids (GSLs) withamphiphilic character that are found at the outer leaflet of the cell membranes, where their ability to organize into special domainsmakes themvital cell membrane components.
Jeffery B. Klauda, Dhilon S. Patel, Emilia L. Wu, Go¨ran Widmalm, Soohyung Park, Wonpil Im, 염민선   +6 more
core  

GM1 structural requirements to mediate neuronal functions

, 2023
Since the 1980s, it has been known that the administration of ganglioside GM1 to cultured cells induced or enhanced neuronal differentiation. GM1 mechanism of action relies on its direct interaction and subsequent activation of the membrane tyrosine ...
Ciampa, Maria Grazia, Maggioni, Margherita, Chiricozzi, Elena, Valsecchi, Manuela, Mauri, Laura, Loberto, Nicoletta, Cioccarelli, Laura, Aureli, Massimo, Palazzolo, Luca, Eberini, Ivano, Carsana, Emma Veronica, Lunghi, Giulia, Fazzari, Maria, Vigani, Laura, Imamura, Akihiro, Saporiti, Simona, Ben Mariem, Omar, Takato, Koichi, Ishida, Hideharu, Sonnino, Sandro, Di Biase, Erika   +20 more
core   +1 more source

Phase III randomized, placebo‐controlled, double‐blind study of monosialotetrahexosylganglioside for the prevention of oxaliplatin‐induced peripheral neurotoxicity in stage II/III colorectal cancer

Cancer Medicine, 2020
Background Monosialotetrahexosylganglioside (GM1) is a neuroprotective glycosphingolipid that repairs nerves. Oxaliplatin‐based chemotherapy is neurotoxic.
De‐shen Wang, Zhi‐qiang Wang, Gong Chen, Jie‐wen Peng, Wei Wang, Yan‐hong Deng, Feng‐hua Wang, Jian‐wei Zhang, Han‐lin Liang, Fen Feng, Chuan‐bo Xie, Chao Ren, Ying Jin, Si‐mei Shi, Wen‐hua Fan, Zhen‐hai Lu, Pei‐rong Ding, Feng Wang, Rui‐hua Xu, Yu‐hong Li   +19 more
doaj   +1 more source

The C‐Type Lectin Mincle Serves as a Pattern Recognition Receptor for the Lipid Envelope of Human Cytomegalovirus

European Journal of Immunology, Volume 56, Issue 9, September 2026.
Whether viral lipids can directly interact with pattern recognition receptors to modulate antiviral immune responses remains unclear. We show that Mincle‐dependent recognition of HCMV viral particles induces proinflammatory cytokine production in primary human macrophages.
Vladimir Bokun, Wengang Chai, Robert Buchanan, Elliot Murphy, Yan Liu, Beth Holder, Alexiane Decout   +6 more
wiley   +1 more source

Isostructural Analysis in Proposed Crystallization Mechanisms at the Molecular Level of Methyl 4‐bromobenzoate and Methyl 4‐iodobenzoate

Helvetica Chimica Acta, Volume 109, Issue 9, September 2026.
Proposed molecular‐level crystallization mechanisms for halogenated aryl esters were developed based on theoretical energetic and topological data regarding intermolecular and supramolecular interactions. Energetic analysis was used to determine the hierarchy of interactions guiding supramolecular structure growth along the three axes, as well as to ...
Patrick Teixeira Campos, Isabella Burchardt Ferreira, Rubia Mara Siqueira da Silva   +2 more
wiley   +1 more source

Small Extracellular Vesicle and Total Lipid Profiles Provide a Diagnostic Advantage Over CA‐125 Across Ovarian Cancer Subtypes

Journal of Extracellular Vesicles, Volume 15, Issue 9, September 2026.
Small extracellular vesicle (sEV) lipid profiles outperform CA‐125 across ovarian cancer histotypes, achieving accuracy up to 0.73 in differential diagnosis and 0.94 in screening. In patients with normal CA‐125 levels, sEV lipids maintain discriminative performance where CA‐125 alone fails. ABSTRACT Ovarian cancer remains the most lethal gynaecological
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Lewis Perrin, Rohan Lourie, Vaibhavi Joshi, Amy E. McCart Reed, Kaltin Ferguson, Aase Handberg, Andreas Möller, Carlos Salomon   +11 more
wiley   +1 more source

Ein Gentest für die GM1-Gangliosidose beim Alaskan Husky

, 2007
Gegenstand und Ziel: Die GM1-Gangliosidose der Alaskan Huskies ist eine angeborene Erkrankung, die durch einen autosomal rezessiv vererbten Defekt des Gens für die saure β-Galaktosidase (GLB1) hervorgerufen wird.
Kreutzer, R, Leeb, Tosso, Müller, G, Brenig, B, Moritz, A, Baumgärtner, W   +5 more
core  

GM1-ganglioside degradation and biosynthesis in human and murine GM1-gangliosidosis

, 2005
Background: Gangliosides are building blocks of cell membranes and their biosynthesis and degradation have been extensively studied in the past. Regulation of the metabolism of these glycolipids controls fundamental cell functions.
Sano, Renata, Giugliani, Roberto, Vieira, Matheus Barbosa, D'Azzo, Alessandra, Trindade, Vera Maria Treis, Tessitore, Alessandra, Coelho, Janice Carneiro   +6 more
core   +1 more source