Results 101 to 110 of about 187,323 (286)

Synergistic Activation of Immunogenic Cell Death and the cGAS–STING Pathway by Engineered Zinc/Manganese‐Based Metal–Organic Framework Nanoplatforms for Colon Cancer Immunotherapy

Advanced Science, EarlyView.
A zinc/manganese (Zn/Mn)‐based metal‐organic framework (MOF) loaded with the STING agonist c‐di‐AMP diammonium (denoted AMP@Zn/Mn‐MOF) was developed to synergistically activate the cGAS‐STING pathway and induce immunogenic cell death. This nanoplatform reprograms the immunosuppressive tumor microenvironment, significantly enhancing anti‐PD‐L1 ...
Bingzi Zhu, Xiaodong Chen, Chang Xu, Xuehua Qian, Binglong Bai, Ji Lin, Wenhai Deng, Xiang Wang, Yuekai Cui, Shengsheng Zhao, Zuoliang Xie, Tao You, Yingpeng Huang, Xian Shen, Xufeng Lu, Weijian Sun   +15 more
wiley   +1 more source

Genetically Modified Products in Lithuania: Situational Analysis and Consumers’ Attitudes [PDF]

The paper analyses the genetically modified organism products (GMP) in relation to genetically modified organisms (GMO) from two perspectives: 1) from the theoretical standpoint, discussing the GMO and GMP trade conditions and 2) from the practical ...
Dainora Grundey, Indre Rimkiene
core  

Effect of recent R_p and R_n measurements on extended Gari-Krumpelmann model fits to nucleon electromagnetic form factors

, 2002
The Gari-Krumpelmann (GK) models of nucleon electromagnetic form factors, in which the rho, omega, and phi vector meson pole contributions evolve at high momentum transfer to conform to the predictions of perturbative QCD (pQCD), was recently extended to
A. Lung, A.F. Sill, A.S. Esaulov, C. Herberg, C.E. Jones-Woodward, C.H. Berger, D. Rohe, E.E.W. Bruins, Earle L. Lomon, Earle L. Lomon, F. Borkowski, G. Höhler, H. Anklin, H. Anklin, H. Gao, H. Zhu, I. Passchier, J. Golak, J.J. Murphy, K.M. Hanson, L. Andivahis, M. Meyerhoff, M. Ostrick, M.F. Gari, M.F. Gari, M.K. Jones, O. Gayou, P. Markowitz, P. Mergell, P.E. Bosted, R.C. Walker, Richard Madey, S. Galster, S. Kopecky, T. Eden, W. Bartel, W. Bartel, W. Bartel, W. Xu   +38 more
core   +1 more source

Cationic mRNA Lipid Nanoparticles for Ex Vivo NanoCAR‐T Cell Engineering

Advanced Science, EarlyView.
This study compares charge‑neutral and cationic lipidnanoparticles (LNPs) for ex vivo mRNA delivery to T cells, revealing distinctdependencies on medium composition and T cell activation. Where conventional LNPs benefit from ApoE‐dependent T cell targeting, cationic DOTAP‑modified LNPs mediate unspecific charge‑dependent transfection.
Laure Harinck, Stijn De Munter, Margo De Velder, Joline Ingels, Dominika Berdecka, Ine Lentacker, Winnok H. De Vos, Bart Vandekerckhove, Kevin Braeckmans, Koen Raemdonck   +9 more
wiley   +1 more source

Comparative analysis of integer factorization algorithms

MANAS: Journal of Engineering, 2015
Integer factorization problem, which is used as the basis in many public key cryptosystem, is generally thought to be hard problem even on a modern computers.
G. Kimsanova, R. Ismailova, R. Sultanov
doaj  

Single‐Cell Dissection of Tumor‐Infiltrating Lymphocytes Reveals Cellular Architecture Predictive of Therapeutic Efficacy in Acral Melanoma

Advanced Science, EarlyView.
Autologous tumor‐infiltrating lymphocyte (TIL) therapy shows promising efficacy in acral melanoma, yet determinants of durable response remain unclear. By integrating single‐cell transcriptomics and TCR sequencing, this study reveals that TIL products enriched for T follicular helper and intermediate exhausted T cells establish persistent clonal ...
Chao Zhang, Wanyi Xiao, Hongru Shen, Fenge Li, Ting Li, Weihong Zhang, Haotian Liu, Ziwei Gao, Hongyu Wang, Xiubao Ren, Kexin Chen, Xiangchun Li, Jilong Yang   +12 more
wiley   +1 more source

Integrative Analyses Identify a cGAS‐STING Pathway‐Driven Signature With Context‐Dependent Roles in Systemic Lupus Erythematosus

Advanced Science, EarlyView.
Zhang et al. identify M7core, a critical cGAS‐STING pathway‐driven gene signature that is activated in most lupus patients’ blood and links to lupus disease severity, lymphopenia, and lupus nephritis. They further reveal the diagnostic and pathogenic characteristics of M7core and emphasize the importance of assessing pathway activity before initiating ...
Lele Zhang, Ming‐Ju Amy Lyu, Ze Hong, Jing Sun, Lan Guo, Jiameng Hu, Munire Maimaiti, Chenhui Li, Jinyi Song, Xiang Zhang, Huansha Yu, Chen Wang, Xuan Wang, Haiyang Hu   +13 more
wiley   +1 more source

Furosemide Enhances the Release of Endothelial Kinsis, Nitric Oxide and Prostacyclin [PDF]

, 1994
Despite a wealth of data, the mechanism of the direct dilator effect of furosemide on the systemic arterial and venous systems is far from being satisfactorily understood.
Fink, Edwin, Hropot, Max, Linz, Wolfgang, Schölkens, Bernward A., Wiemer, Gabriele, Wohlfart, Paulus   +5 more
core  

Outcomes and Duration of Tidal Evolution in a Star-Planet-Moon System

, 2012
We formulated tidal decay lifetimes for hypothetical moons orbiting extrasolar planets with both lunar and stellar tides. Previous work neglected the effect of lunar tides on planet rotation, and are therefore applicable only to systems in which the moon'
Barnes, Borucki, Cassidy, David P. O'Brien, de Pater, Fortney, Han, Hut, Jason W. Barnes, Kaltenegger, Lewis, Mamajek, Rivera, Takashi Sasaki, Ward, Ward   +15 more
core   +1 more source

Bacterial Outer Membrane Vesicles in Potentiating Cancer Vaccines: Progress and Prospects

Advanced Science, EarlyView.
Bacterial outer membrane vesicles (OMVs) have emerged as versatile platforms for cancer vaccine development owing to their intrinsic immunostimulatory properties and high engineering flexibility. This review summarizes OMV biology, immune mechanisms, and engineering strategies that enhance vaccine efficacy, discusses key translational challenges, and ...
Jiabeini Zhang, Tianyu Shao, Fengjiang Qu, Caiyun Bai, Sijie Li, Pin Gao, Wenna Li, Keman Cheng, Xiao Zhao, Zhimin Fan   +9 more
wiley   +1 more source