Results 71 to 80 of about 187,323 (286)

Measurement of GEp/GMp in ep -> ep to Q2 = 5.6 GeV2

open access: yes, 2001
The ratio of the electric and magnetic form factors of the proton, GEp/GMp, was measured at the Thomas Jefferson National Accelerator Facility (JLab) using the recoil polarization technique.
Aniol, KA   +78 more
core   +3 more sources

CypD Dependent mPTP Opening Is Crucial for Oxidized Mitochondrial DNA Release in Ferroptosis

open access: yesAdvanced Science, EarlyView.
Ferroptosis is driven by mitochondrial permeability transition pore (mPTP) opening, which induces mitochondrial swelling and releases oxidized mitochondrial DNA. The released mtDNA activates cGAS–STING signaling, promotes ferritinophagy, and amplifies ferroptotic cell death. Disruption of mtDNA repair sensitizes tumors to ferroptosis in vivo, revealing
Hong Zhou   +5 more
wiley   +1 more source

Improved Lower Bounds on Mutual Information Accounting for Nonlinear Signal-Noise Interaction [PDF]

open access: yes, 2018
In fiber-optic communications, evaluation of mutual information (MI) is still an open issue due to the unavailability of an exact and mathematically tractable channel model.
Agrell, Erik   +4 more
core   +2 more sources

Anti‐PD‐1 Nanobody‐Armored MSLN CAR‐T Therapy for Malignant Mesothelioma: Preclinical and Clinical Studies

open access: yesAdvanced Science, EarlyView.
A novel therapy using engineered immune cells (NAC‐T cells) showed promise for refractory malignant mesothelioma. Based on the encouraging preclinical data, the first‐in‐human trial is initiated, demonstrating tolerable safety and promising anti‐tumor activity (ORR 63.6%, DCR 100%, including one CR).
Yan Sun   +23 more
wiley   +1 more source

Assessing the Correlation Between GMP Deviations and Potential Quality Defects of Medicinal Products: the Result of the Survey of Qualified Persons

open access: yesРазработка и регистрация лекарственных средств, 2020
Introduction. One of the key issues in the field of assessing the conformity of drug manufacturers with the requirements of good manufacturing practice (GMP) is a systematic methodology for classifying revealed deficiencies (deviations, non-conformities)
V. A. Orlov, V. N. Shestakov
doaj   +1 more source

Engineered Mesenchymal Stem Cell–NK Cell Complexes for Spatially Targeted and Functionally Revitalized Cancer Immunotherapy

open access: yesAdvanced Science, EarlyView.
IL‐15‐engineered stem cell–NK cell complexes, assembled via bioorthogonal chemistry, enable effective lung cancer immunotherapy. Abstract Natural killer (NK) cells represent a powerful immunotherapeutic strategy due to their intrinsic cytotoxicity and ability to target tumor cells independently of antigen presentation.
Qian Zhang   +15 more
wiley   +1 more source

Factors of quality management system influencing organizational performance: A study of pharmaceutical factories getting GMP certificate in Vietnam

open access: yesHo Chi Minh City Open University Journal of Science - Economics and Business Administration, 2016
A study objective is to identify key factors of QMS (Quality Management System) influencing the organizational performance in pharmaceutical factories getting GMP (Good Manufacturing Practices) certificate.
Nguyen Thuy Quynh Loan
doaj   +1 more source

Promises, pitfalls and shortfalls of the guaranteed maximum price approach: A comparative case study [PDF]

open access: yes, 2010
The relative merits of the guaranteed maximum price (GMP) mechanism as a contractual incentive in construction have been much contested. This question was investigated using a comparative case study of two building projects in Hong Kong.
Anvuur, AM, Kumaraswamy, MK
core  

Vector and Axial Nucleon Form Factors:A Duality Constrained Parameterization [PDF]

open access: yes, 2007
We present new parameterizations of vector and axial nucleon form factors. We maintain an excellent descriptions of the form factors at low momentum transfers, where the spatial structure of the nucleon is important, and use the Nachtman scaling variable
Avvakumov, S.   +3 more
core   +2 more sources

rWTC‐MBTA Vaccine, Alone and Enhanced with Anti‐PD1, Elicits Immune Responses against CNS and Peripheral B‐Cell Lymphoma

open access: yesAdvanced Science, EarlyView.
An autologous whole‐tumor‐cell vaccine (rWTC‐MBTA) is evaluated in murine CNS lymphoma. Subcutaneous vaccination activates dendritic cells, broadens T‐cell priming, and drives lymphocyte trafficking to brain tumors, producing durable tumor control. Longitudinal bioluminescence and adoptive‐transfer assays verify CNS engagement. Combination with anti‐PD‐
Yaping Zhang   +10 more
wiley   +1 more source

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