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Definition of the hypothalamic GnRH pulse generator in mice. [PDF]

Proc Natl Acad Sci U S A, 2017
Significance Neural networks located in the hypothalamus are responsible for generating ultradian patterns of hormone secretion that control a wide variety of functions. How these neural networks generate pulsatile hormone secretion remains unknown.
Clarkson J +10 more
europepmc +5 more sources

FRI419 Progesterone Regulation Of The GnRH Pulse Generator [PDF]

J Endocr Soc, 2023
Abstract Disclosure: E.G. Wall: None. A group of kisspeptin neurons located in the arcuate nucleus (ARN) of the hypothalamus represent the GnRH pulse generator and their activity is thought to be controlled primarily by the feedback actions of estradiol and progesterone (P4).
Ellen G. Wall
europepmc +4 more sources

The hypothalamic GnRH pulse generator: multiple regulatory mechanisms. [PDF]

Trends Endocrinol Metab, 2009
Pulsatile secretion of gonadotropin-releasing hormone (GnRH) release is an intrinsic property of hypothalamic GnRH neurons. Pulse generation has been attributed to multiple specific mechanisms, including spontaneous electrical activity of GnRH neurons, calcium and cAMP signaling, a GnRH receptor autocrine regulatory component, a GnRH concentration ...
Krsmanovic LZ, Hu L, Leung PK, Feng H, Catt KJ. +4 more
europepmc +5 more sources

Direct evidence that KNDy neurons maintain gonadotropin pulses and folliculogenesis as the GnRH pulse generator. [PDF]

Proc Natl Acad Sci U S A, 2021
SignificanceReports suggest that at least 25% of women suffering from reproductive disorders are due to hypothalamic dysfunction. Pulsatile gonadotropin-releasing hormone (GnRH) regimens are used for infertile women. Thus, elucidation of the GnRH/gonadotropin pulse generator is warranted to improve therapeutic approaches for these disorders.
Nagae M +12 more
europepmc +6 more sources

The GnRH Pulse Generator

AIMS Medical Science, 2016
The pulsatile secretion of hormones is an efficient way of coding a large variety of chemical messages. The GnRH pulse pattern determines which gonadotropin is released when and at what concentration, prescribing a detailed set of instructions to the ...
Pasha Grachev, Robert L. Goodman
doaj +2 more sources

RF01 | PMON45 Urocortin 3 Interaction with GABA and Glutamate in the Posterodorsal Subnucleus of The Medial Amygdala Mediates Suppression of GnRH Pulse Generator Frequency in Female Mice [PDF]