FRI284 The GnRH Pulse Generator Activity In Mouse Models Of Polycystic Ovary Syndrome [PDF]
J Endocr Soc, 2023 Disclosure: Z. Zhou: None. M. Pardo-Navarro: None. S.Y. Han: None. A.E. Herbison: None. Up to one in five women worldwide suffer from polycystic ovary syndrome (PCOS), a condition typified by problems with fertility, high androgen levels, and altered ...
Ziyue Zhou +3 more
europepmc +3 more sources
Direct evidence that KNDy neurons maintain gonadotropin pulses and folliculogenesis as the GnRH pulse generator. [PDF]
Proc Natl Acad Sci U S A, 2021 Significance Reports suggest that at least 25% of women suffering from reproductive disorders are due to hypothalamic dysfunction. Pulsatile gonadotropin-releasing hormone (GnRH) regimens are used for infertile women.
Nagae M +12 more
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FRI419 Progesterone Regulation Of The GnRH Pulse Generator [PDF]
J Endocr Soc, 2023 Disclosure: E.G. Wall: None. A group of kisspeptin neurons located in the arcuate nucleus (ARN) of the hypothalamus represent the GnRH pulse generator and their activity is thought to be controlled primarily by the feedback actions of estradiol and ...
Ellen G. Wall
europepmc +3 more sources
RF01 | PMON45 Urocortin 3 Interaction with GABA and Glutamate in the Posterodorsal Subnucleus of The Medial Amygdala Mediates Suppression of GnRH Pulse Generator Frequency in Female Mice [PDF]
J Endocr Soc, 2022 Stress exerts a profound impact on reproductive function and disrupts pulsatile luteinizing hormone (LH) secretion. The posterodorsal subnucleus of the medial amygdala (MePD) is an upstream modulator of the hypothalamus pituitary gonadal axis.
D. Ivanova +4 more
europepmc +3 more sources
In vivo imaging of the GnRH pulse generator reveals a temporal order of neuronal activation and synchronization during each pulse. [PDF]
Proc Natl Acad Sci U S A, 2022 Significance Hypothalamic oscillators that generate pulsatile patterns of hormone secretion represent a fundamental physiological feature regulating homeostatic systems.
Moore AM, Coolen LM, Lehman MN.
europepmc +3 more sources
OR17-2 GABAergic Signalling in the Posterodorsal Medial Amygdala Mediates Psychological Stress-induced Suppression of the GnRH Pulse Generator in Female Mice [PDF]
J Endocr Soc, 2022 Psychological stress is linked to infertility and reproductive dysfunction by suppressing the hypothalamic gonadotropin-releasing hormone (GnRH) pulse generator and pulsatile luteinising hormone (LH) secretion.
Ross DeBurgh +6 more
europepmc +3 more sources
8602 Classical progesterone signaling in kisspeptin neurons is not required for negative feedback regulation of the GnRH pulse generator in mice [PDF]
J Endocr SocDisclosure: K.M. Dillon: None. D.B. Lohr: None. A.G. Novak: None. A.V. Petriv: None. N.T. Neifert: None. A.M. Moore: None. Mammalian reproductive function depends on the ability of progesterone to suppress pulsatile gonadotropin-releasing hormone (GnRH ...
Kendra M Dillon +5 more
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J Endocr Soc, 2019 KNDy neurons are named for their co-expression of three neuropeptides, kisspeptin, neurokinin B and dynorphin A (Dyn A). These cells, located in the hypothalamic arcuate nucleus (ARC), are assumed to be the generator of GnRH/LH pulses that control ...
Munetomo A +3 more
europepmc +3 more sources
EndocrinologyA subpopulation of kisspeptin neurons in the arcuate nucleus (ARN) of the hypothalamus functions as the GnRH pulse generator, driving the pulsatile secretion of LH from the anterior pituitary.
Chang B, Wall EG, Herbison AE, Han SY.
europepmc +3 more sources
AIMS Medical Science, 2016 The pulsatile secretion of hormones is an efficient way of coding a large variety of chemical messages. The GnRH pulse pattern determines which gonadotropin is released when and at what concentration, prescribing a detailed set of instructions to the ...
Pasha Grachev, Robert L. Goodman
doaj +3 more sources