Results 21 to 30 of about 3,060 (210)

GnRH pulse generator frequency is modulated by kisspeptin and GABA-glutamate interactions in the posterodorsal medial amygdala in female mice. [PDF]

J Neuroendocrinol, 2022
Lass G, Li XF, Voliotis M, Wall E, de Burgh RA, Ivanova D, McIntyre C, Lin XH, Colledge WH, Lightman SL, Tsaneva-Atanasova K, O'Byrne KT.   +11 more
europepmc   +3 more sources

Precision Targeted Therapy for PCOS: Emerging Drugs, Translational Challenges, and Future Opportunities [PDF]

Biomedicines
Polycystic Ovary Syndrome (PCOS) is characterized by a self-perpetuating vicious cycle between insulin resistance (IR) and hyperandrogenism (HA). While lifestyle management remains the internationally recommended first-line treatment, current clinical ...
Xinhong Wu, Wei Yi, Xiawen Liu
doaj   +2 more sources

The Origin of GnRH Pulse Generation:An Integrative Mathematical-Experimental Approach [PDF]

The Journal of Neuroscience, 2014
Fertility critically depends on the gonadotropin-releasing hormone (GnRH) pulse generator, a neural construct comprised of hypothalamic neurons coexpressing kisspeptin, neurokoinin-B and dynorphin.
De Burgh, Ross, Lass, Geffen, Li, Xiao Feng, Lightman, Stafford L., O'Byrne, Kevin T., Tsaneva-Atanasova, Krasimira, Voliotis, Margaritis   +6 more
core   +12 more sources

Hypothalamic PVN CRH Neurons Signal Through PVN GABA Neurons to Suppress GnRH Pulse Generator Frequency in Female Mice. [PDF]

Endocrinology, 2023
McIntyre C, Li XF, Ivanova D, Wang J, O'Byrne KT.   +4 more
europepmc   +2 more sources

8602 Classical progesterone signaling in kisspeptin neurons is not required for negative feedback regulation of the GnRH pulse generator in mice [PDF]

J Endocr Soc
K. Dillon, Dayanara B Lohr, Alyssa G Novak, Anna-Maria V Petriv, Nicole T Neifert, Aleisha M. Moore   +5 more
europepmc   +2 more sources

Kisspeptin, neurokinin B, and dynorphin act in the arcuate nucleus to control activity of the GnRH pulse generator in ewes. [PDF]

Endocrinology, 2013
Goodman RL, Hileman SM, Nestor CC, Porter KL, Connors JM, Hardy SL, Millar RP, Cernea M, Coolen LM, Lehman MN.   +9 more
europepmc   +2 more sources

OR09-02 Chemogenetic Manipulation Of Brainstem Noradrenergic Neurons Modulates The Activity Of The Kisspeptin GnRH Pulse Generator In Mice [PDF]

J Endocr Soc, 2023
Szilvia Vas, Miguel Ruiz-Cruz, Su Young Han, Shel Hwa‐Yeo, Allan E. Herbison   +4 more
europepmc   +2 more sources

Electrophysiological studies on the hypothalamic GnRH pulse generator

Nihon Naibunpi Gakkai zasshi, 1992
Gonadal function in mammals depends on gonadotropins secreted from the pituitary gland in a pulsatile manner. This pulsatility is governed by the periodic activation of the hypothalamic GnRH pulse generator. By means of multiple unit activity (MUA) recording techniques, characteristics increases in the neuronal activity, each of which is associated ...
Masugi Nishihara, Hiromi HIRUMA, Yuji MORI   +2 more
  +6 more sources

Mathematical modeling of the GnRH pulse and surge generator [PDF]

SIAM Journal on Applied Dynamical Systems, 2005
We propose a mathematical model allowing for the alternating pulse and surge pattern of GnRH (Gonadotropin Releasing Hormone) secretion. The model is based on the coupling between two systems running on different time scales. The faster system corresponds to the average activity of GnRH neurons, while the slower one corresponds to the average activity ...
Frédérique Clément, Jean–Pierre Françoise   +1 more
openalex   +4 more sources

Electrophysiological approach to the hypothalamic GnRH pulse generator [PDF]

Bioscientifica Proceedings, 2019
The hypothalamic GnRH pulse generator that regulates intermittent GnRH discharge into the pituitary portal circulation and thereby modulates pulsatile secretion of LH has been recognized as a key determinant of the reproductive function in mammals. Thus, various internal, as well as external, factors first modify the electrical activity of the GnRH ...
Yoshinobu Mori, Tetsuji Tanaka
openalex   +3 more sources