Kisspeptin Is a Component of the Pulse Generator for GnRH Secretion in Female Sheep But Not THE Pulse Generator [PDF]
Endocrinology, 2015 We tested the hypothesis that kisspeptin cells constitute the “pulse generator” for GnRH secretion. In ewes, we determined whether iv administered kisspeptin elicits a secretory pulse of LH in anaesthetized, sex-steroid suppressed ovariectomized ewes.
Ahmed Ezzat +2 more
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Role of Posterodorsal Medial Amygdala Urocortin-3 in Pubertal Timing in Female Mice
Frontiers in Endocrinology, 2022 Post-traumatic stress disorder impedes pubertal development and disrupts pulsatile LH secretion in humans and rodents. The posterodorsal sub-nucleus of the medial amygdala (MePD) is an upstream modulator of the hypothalamic gonadotropin-releasing hormone
Deyana Ivanova +8 more
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Ghrelin Decreases Firing Activity of Gonadotropin-Releasing Hormone (GnRH) Neurons in an Estrous Cycle and Endocannabinoid Signaling Dependent Manner. [PDF]
, 2013 The orexigenic peptide, ghrelin is known to influence function of GnRH neurons, however, the direct effects of the hormone upon these neurons have not been explored, yet.
Farkas, Imre +3 more
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eLife, 2021 Pulsatile GnRH release is essential for normal reproductive function. Kisspeptin secreting neurons found in the arcuate nucleus, known as KNDy neurons for co-expressing neurokinin B, and dynorphin, drive pulsatile GnRH release.
Margaritis Voliotis +7 more
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Dynamics of pulsatile activities of arcuate kisspeptin neurons in aging female mice
eLife, 2023 Reproductive senescence is broadly observed across mammalian females, including humans, eventually leading to a loss of fertility. The pulsatile secretion of gonadotropin-releasing hormone (GnRH), which is essential for gonad function, is primarily ...
Teppei Goto +2 more
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Studies of the GnRH pulse generator. Developmental and location-specific regulation of GnRH secretion [PDF]
, 2014 The hypothalamo-pituitary-gonadal (HPG) axis governs reproductive function. Gonadotropin-releasing hormone (GnRH) neurons play a critical role in the central regulation of the HPG axis through the episodic release of the GnRH peptide to the hypophyseal blood.
Katarzyna M. Glanowska
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A population of kisspeptin/neurokinin B neurons in the arcuate nucleus may be the central target of the male effect phenomenon in goats. [PDF]
PLoS ONE, 2013 Exposure of females to a male pheromone accelerates pulsatile gonadotropin-releasing hormone (GnRH) secretion in goats. Recent evidence has suggested that neurons in the arcuate nucleus (ARC) containing kisspeptin and neurokinin B (NKB) play a pivotal ...
Kohei Sakamoto +6 more
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Opioidergic pathways and kisspeptin in the regulation of female reproduction in mammals
Frontiers in Neuroscience, 2022 Endogenous opioid peptides have attracted attention as critical neuropeptides in the central mechanism regulating female reproduction ever since the discovery that arcuate dynorphin neurons that coexpress kisspeptin and neurokinin B (NKB), which are also
Yoshihisa Uenoyama +4 more
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eLife, 2021 The necessity and functional significance of neurotransmitter co-transmission remains unclear. The glutamatergic ‘KNDy’ neurons co-express kisspeptin, neurokinin B (NKB), and dynorphin and exhibit a highly stereotyped synchronized behavior that reads out
Xinhuai Liu +7 more
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The Journal of Reproduction and Development, 2020 Accumulating evidence suggests that KNDy neurons located in the hypothalamic arcuate nucleus (ARC), which are reported to express kisspeptin, neurokinin B, and dynorphin A, are indispensable for the gonadotropin-releasing hormone (GnRH) pulse generation ...
Takuya SASAKI +14 more
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