Results 41 to 50 of about 3,060 (210)

Emerging Perspectives on Gonadotropin Regulation in Vertebrates Revealed by the Discovery of FSH-RH in Teleosts. [PDF]

Bioessays
Regarding pituitary gonadotropin regulation, recent studies have shown that in mammals, FSH and LH are regulated by a single GnRH (solo GnRH model), whereas in teleosts, they are regulated by CCK (FSH‐RH) and GnRH (LH‐RH), respectively (dual GnRH model).
Kayo D, Uehara SK, Royan MR, Kanda S.
europepmc   +2 more sources

Characterization of GnRH Pulse Generator Activity in Male Mice Using GCaMP Fiber Photometry [PDF]

Endocrinology, 2019
Kisspeptin neurons located in the hypothalamic arcuate nucleus are thought to represent the GnRH pulse generator responsible for driving pulsatile LH secretion. The recent development of GCaMP6 fiber photometry technology has made it possible to perform long-term recordings of the population activity of the arcuate nucleus kisspeptin (ARNKISS) neurons ...
Su Young Han, Grace Kane, Isaiah Cheong, Allan E. Herbison   +3 more
openalex   +3 more sources

GnRH Pulse Generator Activity Across the Estrous Cycle of Female Mice [PDF]

Endocrinology, 2019
A subpopulation of kisspeptin neurons located in the arcuate nucleus (ARN) operate as the GnRH pulse generator. The activity of this population of neurons can be monitored in real-time for long periods using kisspeptin neuron-selective GCaMP6 fiber photometry.
H James McQuillan, Su Young Han, Isaiah Cheong, Allan E Herbison   +3 more
openaire   +3 more sources

Bifurcation-based parameter tuning in a model of the GnRH pulse and surge generator [PDF]

, 2008
We investigate a model of the GnRH pulse and surge generator, with the definite aim of constraining the model GnRH output with respect to a physiologically relevant list of specifications. The alternating pulse and surge pattern of secretion results from
Alexandre Vidal, Camproux A.-C., Dumortier F., Frédérique Clément   +3 more
core   +5 more sources

Kisspeptin-neuron control of LH pulsatility and ovulation

Frontiers in Endocrinology, 2022
Feedback from oestradiol (E2) plays a critical role in the regulation of major events in the physiological menstrual cycle including the release of gonadotrophins to stimulate follicular growth, and the mid-cycle luteinising hormone (LH) surge that leads
Harvey Stevenson, Samuel Bartram, Mikaela Maria Charalambides, Sruthi Murthy, Theo Petitt, Anjali Pradeep, Owen Vineall, Ikenna Abaraonye, Amelia Lancaster, Kanyada Koysombat, Bijal Patel, Ali Abbara   +11 more
doaj   +1 more source

The Role of the Brain in the Pathogenesis and Physiology of Polycystic Ovary Syndrome (PCOS). [PDF]

, 2019
Polycystic ovary syndrome (PCOS) is a common reproductive endocrine disorder, affecting at least 10% of women of reproductive age. PCOS is typically characterized by the presence of at least two of the three cardinal features of hyperandrogenemia (high ...
Coutinho, Eulalia A, Kauffman, Alexander S   +1 more
core   +1 more source

Investigating the KNDy hypothesis in humans by co-administration of kisspeptin, neurokinin B and naltrexone in men [PDF]

, 2016
Context: A subpopulation of hypothalamic neurons co-localise three neuropeptides namely kisspeptin, neurokinin B (NKB) and dynorphin collectively termed KNDy neurons. Animal studies suggest they interact to affect pulsatile GnRH release (KNDy hypothesis);
Abbara, A, Bassett, P, Bloom, S, COMNINOS, A, Dhillo, WS, Jayasena, C, Mizamtsidi, M, Narayanaswamy, S, Papadopoulou, D, Prague, J, Shah, A, Veldhuis, J   +11 more
core   +1 more source

The GnRH pulse generator activity in mouse models of polycystic ovary syndrome

Abstract One in five women worldwide suffer from polycystic ovary syndrome (PCOS) that, alongside subfertility and hyperandrogenism, typically presents with increased luteinizing hormone (LH) pulsatility. As such, it is suspected that the arcuate kisspeptin (ARNKISS) neurons that represent the GnRH pulse generator are dysfunctional in ...
Ziyue Zhou, Su Young Han, Maria Pardo-Navarro, Ellen G. Wall, Reena Desai, Szilvia Vas, David J. Handelsman, Allan E. Herbison   +7 more
openalex   +2 more sources

Pulsatile Hormonal Signaling to Extracellular Signal-Regulated Kinase: Exploring System Sensitivity to Gonadotropin-Releasing Hormone Pulse Frequency and Width [PDF]

, 2014
Gonadotropin-releasing hormone (GnRH) is secreted in brief pulses that stimulate synthesis and secretion of pituitary gonadotropin hormones and thereby mediate control of reproduction.
Armstrong, Armstrong, Armstrong, Armstrong, Barrell, Belchetz, Bliss, Bliss, Burger, Bédécarrats, Cardenas, Caunt, Caunt, Caunt, Chuderland, Ciccone, Clayton, Crowley, Cullen, Durham, Ferris, Haisenleder, Haisenleder, Kanasaki, Lawson, Markevich, Marshall, Marshall, Millar, Moenter, Naor, O'Byrne, Padmanabhan, Purvis, Reiss, Savoy-Moore, Shupnik, Sisk, Tomida, Tsaneva-Atanasova, Tsutsumi, Williams   +41 more
core   +2 more sources

The neurochemistry of the GnRH pulse generator

Acta Neurobiologiae Experimentalis, 1996
We review the crucial role of the two neurotransmitters norepinephrine (NE) and GABA in eliciting GnRH pulses. NE acts via an alpha1-receptor mechanism and also GABA acts at the alpha-subtype of the GABA receptor. The function of NE appears to be induction of phasic activation of GnRH neurons and GABA inhibits GnRH neurons tonically until they are all ...
Wuttke, W., Jarry, H., Feleder, C., Moguilevsky, J., Leonhardt, S., Seong, J. Y., Kim, K.   +6 more
openaire   +3 more sources