Results 41 to 50 of about 41,351 (154)

Peripheral administration of SB223412, a selective neurokinin-3 receptor antagonist, suppresses pulsatile luteinizing hormone secretion by acting on the gonadotropin-releasing hormone pulse generator in estrogen-treated ovariectomized female goats

The Journal of Reproduction and Development, 2020
Accumulating evidence suggests that KNDy neurons located in the hypothalamic arcuate nucleus (ARC), which are reported to express kisspeptin, neurokinin B, and dynorphin A, are indispensable for the gonadotropin-releasing hormone (GnRH) pulse generation ...
Takuya SASAKI, Tomoya SONODA, Ryoki TATEBAYASHI, Yuri KITAGAWA, Shinya OISHI, Koki YAMAMOTO, Nobutaka FUJII, Naoko INOUE, Yoshihisa UENOYAMA, Hiroko TSUKAMURA, Kei-ichiro MAEDA, Fuko MATSUDA, Yasuhiro MORITA, Shuichi MATSUYAMA, Satoshi OHKURA   +14 more
doaj   +1 more source

Kisspeptin-neuron control of LH pulsatility and ovulation

Frontiers in Endocrinology, 2022
Feedback from oestradiol (E2) plays a critical role in the regulation of major events in the physiological menstrual cycle including the release of gonadotrophins to stimulate follicular growth, and the mid-cycle luteinising hormone (LH) surge that leads
Harvey Stevenson, Samuel Bartram, Mikaela Maria Charalambides, Sruthi Murthy, Theo Petitt, Anjali Pradeep, Owen Vineall, Ikenna Abaraonye, Amelia Lancaster, Kanyada Koysombat, Bijal Patel, Ali Abbara   +11 more
doaj   +1 more source

Long-term Recording of Hypothalamic GnRH Pulse Generator Activity during Programmed Administration of Progesterone and Estradiol in the Ovariectomized Goat

, 1994
Tomomi Tanaka, Y. Mori, K. Hoshino
semanticscholar   +3 more sources

The neurobiological mechanism underlying hypothalamic GnRH pulse generation: the role of kisspeptin neurons in the arcuate nucleus [version 2; peer review: 4 approved]

F1000Research, 2020
This review recounts the origins and development of the concept of the hypothalamic gonadotropin-releasing hormone (GnRH) pulse generator. It starts in the late 1960s when striking rhythmic episodes of luteinizing hormone secretion, as reflected by ...
Tony M. Plant
doaj   +1 more source

Perinatal exposure to the fungicide ketoconazole alters hypothalamic control of puberty in female rats

Frontiers in Endocrinology, 2023
IntroductionEstrogenic endocrine disrupting chemicals (EDCs) such as diethylstilbestrol (DES) are known to alter the timing of puberty onset and reproductive function in females.
Delphine Franssen, Hanna K. L. Johansson, David Lopez-Rodriguez, Arnaud Lavergne, Quentin Terwagne, Julie Boberg, Sofie Christiansen, Terje Svingen, Anne-Simone Parent, Anne-Simone Parent   +9 more
doaj   +1 more source

GnRH Pulse Generator Activity Across the Estrous Cycle of Female Mice.

Endocrinology, 2019
A subpopulation of kisspeptin neurons located in the arcuate nucleus (ARN) operate as the GnRH pulse generator. The activity of this population of neurons can be monitored in real-time for long periods using kisspeptin neuron-selective GCaMP6 fiber ...
McQuillan Hj, S. Han, Isaiah Cheong, A. Herbison   +3 more
semanticscholar   +1 more source

Novel insights into the metabolic action of Kiss1 neurons

Endocrine Connections, 2020
Kiss1 neurons are essential regulators of the hypothalamic–pituitary–gonadal (HPG) axis by regulating gonadotropin-releasing hormone (GnRH) release. Compelling evidence suggests that Kiss1 neurons of the arcuate nucleus (Kiss1ARC), recently identified as
Rajae Talbi, Victor M Navarro
doaj   +1 more source

Optogenetic stimulation of Kiss1ARC terminals in the AVPV induces surge-like luteinizing hormone secretion via glutamate release in mice

Frontiers in Endocrinology, 2022
Kisspeptin neurons are mainly located in the arcuate (Kiss1ARC, vis-à-vis the GnRH pulse generator) and anteroventral periventricular nucleus (Kiss1AVPV, vis-à-vis the GnRH surge generator).
Xi Shen, Xi Shen, Yali Liu, Xiao Feng Li, Hui Long, Li Wang, Qifeng Lyu, Yanping Kuang, Kevin T. O’Byrne   +8 more
doaj   +1 more source

Induction of Gonadotropins for Reproductive Control

Journal of Dentistry Indonesia, 2015
Much of the recent research on gonadotropin – related control processes of reproduction and reproductive maturation has concentrated on the neuronal and molecular biology of gonadotropin release.
Elza Ibrahim Auerkari
doaj   +1 more source

Circulating levels and the bioactivity of miR-30b increase during pubertal progression in boys

Frontiers in Endocrinology, 2023
BackgroundPuberty marks the transition from childhood to adulthood and is initiated by activation of a pulsatile GnRH secretion from the hypothalamus.
Nina Mørup, Nina Mørup, Rytis Stakaitis, Rytis Stakaitis, Rytis Stakaitis, Ailsa Maria Main, Ailsa Maria Main, Ailsa Maria Main, Ieva Golubickaite, Ieva Golubickaite, Ieva Golubickaite, Casper P. Hagen, Casper P. Hagen, Anders Juul, Anders Juul, Anders Juul, Kristian Almstrup, Kristian Almstrup, Kristian Almstrup   +18 more
doaj   +1 more source