Results 51 to 60 of about 3,060 (210)

The neurobiological mechanism underlying hypothalamic GnRH pulse generation: the role of kisspeptin neurons in the arcuate nucleus [version 2; peer review: 4 approved]

F1000Research, 2020
This review recounts the origins and development of the concept of the hypothalamic gonadotropin-releasing hormone (GnRH) pulse generator. It starts in the late 1960s when striking rhythmic episodes of luteinizing hormone secretion, as reflected by ...
Tony M. Plant
doaj   +1 more source

SUN-199 The Kappa Opioid Receptor (KOR)-Expressing Neurons Localize in the Ventromedial Hypothalamic Nucleus and Project to KNDy Neurons, the GnRH Pulse Generator, in Rats

J Endocr Soc, 2019
Munetomo A, Nakajima D, Maeda K, Matsuda F.   +3 more
europepmc   +2 more sources

Morphological evidence for enhanced kisspeptin and neurokinin B signaling in the infundibular nucleus of the aging man. [PDF]

, 2012
Peptidergic neurons synthesizing kisspeptin (KP) and neurokinin B (NKB) in the hypothalamic infundibular nucleus have been implicated in negative sex steroid feedback to GnRH neurons. In laboratory rodents, testosterone decreases KP and NKB expression in
Bloom, Stephen R., Borsay, Beáta Á., Ciofi, Philippe, Dhillo, Waljit S., Ghatei, Mohammad A., Herczeg, László, Hrabovszky, Erik, Liposits, Zsolt, Molnár, Csilla S., Rácz, Kálmán, Sipos, Máté T., Vida, Barbara   +11 more
core   +1 more source

Perinatal exposure to the fungicide ketoconazole alters hypothalamic control of puberty in female rats

Frontiers in Endocrinology, 2023
IntroductionEstrogenic endocrine disrupting chemicals (EDCs) such as diethylstilbestrol (DES) are known to alter the timing of puberty onset and reproductive function in females.
Delphine Franssen, Hanna K. L. Johansson, David Lopez-Rodriguez, Arnaud Lavergne, Quentin Terwagne, Julie Boberg, Sofie Christiansen, Terje Svingen, Anne-Simone Parent, Anne-Simone Parent   +9 more
doaj   +1 more source

Novel insights into the metabolic action of Kiss1 neurons

Endocrine Connections, 2020
Kiss1 neurons are essential regulators of the hypothalamic–pituitary–gonadal (HPG) axis by regulating gonadotropin-releasing hormone (GnRH) release. Compelling evidence suggests that Kiss1 neurons of the arcuate nucleus (Kiss1ARC), recently identified as
Rajae Talbi, Victor M Navarro
doaj   +1 more source

Optogenetic stimulation of Kiss1ARC terminals in the AVPV induces surge-like luteinizing hormone secretion via glutamate release in mice

Frontiers in Endocrinology, 2022
Kisspeptin neurons are mainly located in the arcuate (Kiss1ARC, vis-à-vis the GnRH pulse generator) and anteroventral periventricular nucleus (Kiss1AVPV, vis-à-vis the GnRH surge generator).
Xi Shen, Xi Shen, Yali Liu, Xiao Feng Li, Hui Long, Li Wang, Qifeng Lyu, Yanping Kuang, Kevin T. O’Byrne   +8 more
doaj   +1 more source

Timing feedback-inhibition of the male reproductive hormone axis [PDF]

, 2008
Hormonal methods of male contraception have addressed feedback-inhbition of the cascade of hormones that has evolved to regulate sperm production but high concentrations of testosterone (T) in the blood have not worked satisfactorily.
Amit Misra, Gopal Gupta, K Subramanian Venkatesh, Ritu R. Malik, Shailesh S. Tondwal   +4 more
core   +2 more sources

Afferent Neuronal Control of Type-I Gonadotropin Releasing Hormone Neurons in the Human. [PDF]

, 2013
Understanding the regulation of the human menstrual cycle represents an important ultimate challenge of reproductive neuroendocrine research. However, direct translation of information from laboratory animal experiments to the human is often complicated ...
Hrabovszky, Erik, Liposits, Zsolt
core   +1 more source

Induction of Gonadotropins for Reproductive Control

Journal of Dentistry Indonesia, 2015
Much of the recent research on gonadotropin – related control processes of reproduction and reproductive maturation has concentrated on the neuronal and molecular biology of gonadotropin release.
Elza Ibrahim Auerkari
doaj   +1 more source

Circulating levels and the bioactivity of miR-30b increase during pubertal progression in boys

Frontiers in Endocrinology, 2023
BackgroundPuberty marks the transition from childhood to adulthood and is initiated by activation of a pulsatile GnRH secretion from the hypothalamus.
Nina Mørup, Nina Mørup, Rytis Stakaitis, Rytis Stakaitis, Rytis Stakaitis, Ailsa Maria Main, Ailsa Maria Main, Ailsa Maria Main, Ieva Golubickaite, Ieva Golubickaite, Ieva Golubickaite, Casper P. Hagen, Casper P. Hagen, Anders Juul, Anders Juul, Anders Juul, Kristian Almstrup, Kristian Almstrup, Kristian Almstrup   +18 more
doaj   +1 more source