Results 61 to 70 of about 3,060 (210)

KNDy neurons as an indirect target of insulin-like growth factor-1. [PDF]

J Neuroendocrinol
Abstract Neurons in the arcuate nucleus of the hypothalamus (ARH) that coexpress kisspeptin, neurokinin B, and dynorphin (KNDy neurons) are considered the gonadotropin‐releasing hormone (GnRH) pulse generator necessary for fertility. KNDy neurons are also metabolic sensors controlling the hypothalamic–pituitary‐gonadal (HPG) axis.
Silva JDN, de Sousa LMM, de Sousa ME, Vieira HR, Alves GA, Neifert NT, Moore AM, Donato J, Frazao R.   +8 more
europepmc   +2 more sources

Kisspeptin Neurons in the Infundibular Nucleus of Ovariectomized Cats and Dogs Exhibit Unique Anatomical and Neurochemical Characteristics

Frontiers in Neuroscience, 2020
Neurons co-synthesizing kisspeptin (KP), neurokinin B (NKB), and dynorphin (“KNDy neurons”) in the hypothalamic arcuate/infundibular nucleus (INF) form a crucial component of the gonadotropin-releasing hormone (GnRH)/luteinizing hormone (LH) “pulse ...
Éva Rumpler, Szabolcs Takács, Balázs Göcz, Ferenc Baska, Ottó Szenci, Ottó Szenci, András Horváth, Philippe Ciofi, Erik Hrabovszky, Katalin Skrapits   +9 more
doaj   +1 more source

eLife Assessment: The GnRH pulse generator activity in mouse models of polycystic ovary syndrome

Wei Yan
openalex   +2 more sources

Low Degree of Overlap Between Kisspeptin, Neurokinin B, and Dynorphin Immunoreactivities in the Infundibular Nucleus of Young Male Human Subjects Challenges the KNDy Neuron Concept. [PDF]

, 2012
Previous immunohistochemical and in situ hybridization studies of sheep, goats, and rodents indicated that kisspeptin (KP), neurokinin B (NKB), and dynorphin A (DYN) are extensively colocalized in the hypothalamic arcuate nucleus, thus providing a basis ...
Borsay, Beáta Ágnes, Ciofi, Philippe, Gergely, Péter, Herczeg, László, Hrabovszky, Erik, Liposits, Zsolt, Molnár, Csilla, Sipos, Máté   +7 more
core   +1 more source

Mathematical modelling elucidates core mechanisms underpinning GnRH pulse generation [PDF]

, 2018
SummaryFertility critically depends on the gonadotropin-releasing hormone (GnRH) pulse generator, a neural construct comprised of hypothalamic neurons co-expressing kisspeptin, neurokoinin-B and dynorphin that drives the pulsatile release of GnRH.
Voliotis, Margaritis, Li, Xiao Feng, De Burgh, Ross, Lass, Geffen, Lightman, Stafford L, O’Byrne, Kevin T., Tsaneva-Atanasova, Krasimira   +6 more
openaire   +1 more source

Dynamic Hormone Control of Stress and Fertility

Frontiers in Physiology, 2020
Neuroendocrine axes display a remarkable diversity of dynamic signaling processes relaying information between the brain, endocrine glands, and peripheral target tissues.
Eder Zavala, Eder Zavala, Margaritis Voliotis, Tanja Zerenner, Joël Tabak, Jamie J. Walker, Jamie J. Walker, Xiao Feng Li, John R. Terry, John R. Terry, Stafford L. Lightman, Kevin O'Byrne, Krasimira Tsaneva-Atanasova, Krasimira Tsaneva-Atanasova   +13 more
doaj   +1 more source

Acute progesterone feedback on gonadotropin secretion is not demonstrably altered in estradiol‐pretreated women with polycystic ovary syndrome

Physiological Reports, 2022
Women with polycystic ovary syndrome (PCOS) demonstrate gonadotropin‐releasing hormone (GnRH) pulse generator resistance to suppression with 7 days of progesterone and estradiol administration.
Su Hee Kim, Jessica A. Lundgren, James T. Patrie, Christine M. Burt Solorzano, Christopher R. McCartney   +4 more
doaj   +1 more source

Dissociation between Cervical Mucus and Urinary Hormones during the Postpartum Return of Fertility in Breastfeeding Women [PDF]

, 2018
Identifying the return of fertility with cervical mucus observations is challenging during the postpartum period. Use of urinary measurements of estrogen and progesterone can assist in understanding the return to fertility during this period.
Blackwell, Len, Bouchard, Thomas, Brown, Simon, Fehring, Richard, Parenteau-Carreau, Suzanne   +4 more
core   +2 more sources

Heritability of reproductive hormones in adult male twins [PDF]

, 2007
Background: Proper functioning of the male reproductive axis depends on complex feedback systems between several hormones. In this study, the genetic contribution of various endocrine components of the hypothalamic-pituitary-testicular axis is evaluated ...
Blankenstein, M.A., Boomsma, D.I., Geus, E.J.C. de, Kuijper, E.A.M., Lambalk, C.B., Posthuma, D., Sluis, S. van der   +6 more
core   +3 more sources

The neurobiological mechanism underlying hypothalamic GnRH pulse generation: the role of kisspeptin neurons in the arcuate nucleus [version 1; peer review: 4 approved]

F1000Research, 2019
This review recounts the origins and development of the concept of the hypothalamic gonadotropin-releasing hormone (GnRH) pulse generator. It starts in the late 1960s when striking rhythmic episodes of luteinizing hormone secretion, as reflected by ...
Tony M. Plant
doaj   +1 more source