Results 71 to 80 of about 328,019 (196)

OG716: Designing a fit-for-purpose lantibiotic for the treatment of Clostridium difficile infections. [PDF]

PLoS ONE, 2018
Lantibiotics continue to offer an untapped pipeline for the development of novel antibiotics. We report here the discovery of a novel lantibiotic for the treatment of C. difficile infection (CDI).
Johan A Kers, Anthony W DeFusco, Jae H Park, Jin Xu, Mark E Pulse, William J Weiss, Martin Handfield   +6 more
doaj   +1 more source

Thymus and Leishmania at the Crossroads: Autoimmunity and Cancer

Immunology, Volume 178, Issue 3, Page 377-386, July 2026.
Conceptual ‘Crossroads Model’ linking Leishmania, thymic infection and immune dysregulation: an integrative model is proposed in which Leishmania infection disrupts thymic architecture and stromal–thymocyte interactions. These alterations converge to promote defective tolerance, increased autoimmune risk and a microenvironment permissive to malignant ...
Alef Batista Bezerra Barros, Gabriel Augusto Leite, Arthur Gomes de Andrade, Maria Danielma dos Santos Reis, Luiz Henrique Agra Cavalcante‐Silva, Marvin Paulo Lins   +5 more
wiley   +1 more source

7,12-Dimethylbenz[a]anthracene-induced 'early' squamous cell carcinoma in the golden syrian hamster: Evaluation of an animal model and comparison with 'early' forms of human squamous cell carcinoma in the upper aero-digestive tract

, 1996
To test and optimize photodynamic therapy of early cancers in the upper aero-digestive tract and oesophagus, we sought an appropriate animal model, which was found in the 7,12-dimethylbenz[a]anthracene-induced early squamous cell carcinoma in the Golden ...
Savary, J. F., van den Bergh, H., Fontolliet, C., Andrejevic, S., Monnier, P.   +4 more
core   +1 more source

A Histological Study of the Pigment Development in the Skin of the Syrian Golden Hamster and the Albino Hamster With Particular Attention to the Ear

, 1960
I. INTRODUCTIONThe skin of the Syrian golden hamster, Mesocricetus auratus (L.) is without color at birth, and apparently without hair covering, but within a few days the animal acquires a grayish-brown coat.
Tice, Mary Claudia
core   +1 more source

Tumours of the lower respiratory tract

, 2022
S.189-222In attempts to find appropriate animal models for human lung cancer, many experimental studies have used rats or mice treated with chemicals, viruses or radiation. Since the successful induction of tumours in the respiratory system of the Syrian
Dungworth, D.L., Ernst, H., Mohr, U., Emura, M.   +3 more
core   +1 more source

Naturally Occurring CodY Variants Alter Ligand Binding, DNA Target Affinity, and Virulence in Clostridioides difficile

Molecular Microbiology, Volume 126, Issue 1, Page 98-110, July 2026.
Single amino acid substitutions in the global regulator CodY can alter nutrient sensing and virulence regulation in Clostridioides difficile. We show that the CodY(Y146N) and CodY(V58A) variants display altered ligand binding and reduced promoter binding, leading to derepression of toxin regulatory pathways and increased virulence in vivo.
Md Kamrul Hasan, Sourav Roy, Revathi Govind   +2 more
wiley   +1 more source

The feasibility of establishing a hamster model for HBV infection: in vitro evidence

mBio
Chronic hepatitis B virus (HBV) infection remains a significant public health burden with no cure currently available. The research to cure HBV has long been hampered by the lack of immunocompetent small animal models capable of supporting HBV infection.
Hu Zhang, Yanan Liu, Cheng-Der Liu, Zhongde Wang, Haitao Guo   +4 more
doaj   +1 more source

Metabolic Reprogramming and GM‐CSF Secretion in Areca Nut‐Activated Fibroblasts Drive Oral Precancer Progression

Oral Diseases, Volume 32, Issue 7, Page 1889-1902, July 2026.
ABSTRACT Objective Oral cancer, with a rising global incidence and poor prognosis, is associated with areca nut use in South and Southeast Asia. In this study, we addressed the effects of areca nut extract (ANE) on oral carcinogenesis by modulating fibroblast behavior in oral tissue.
Yen‐Yun Wang, Chang‐Wei Su, Chih‐Huang Tseng, Pang‐Yu Chen, Hieu D. H. Nguyen, Leong‐Perng Chan, Yuk‐Kwan Chen, Shih Sheng Jiang, Steven Lo, Shyng‐Shiou F. Yuan   +9 more
wiley   +1 more source

Harnessing Fatty Acid By‐Products for Diabetes Management: Insights From Nutritional and Biological Research

eFood, Volume 7, Issue 3, June 2026.
Bioactive fatty acids from agro‐industrial byproducts are highlighted as a promising avenue for managing diabetes in this review, which aims to develop targeted interventions for optimal utilization and therapeutic benefits. ABSTRACT Diabetes mellitus (DM), influenced by multifaceted factors, creates a complex imbalance within the body. Nutrition plays
Youssef Elouafy, Abdelaali Balahbib, Meriem El Fessikh, Saïd Gharby, Nasreddine El Omari, Waleed Al Abdulmonem, Gokhan Zengin, Abdelhakim Bouyahya   +7 more
wiley   +1 more source

Efeitos de diferentes períodos de isolamento social sobre o comportamento de hamsters dourados (Mesocricetus auratus) a curto e longo prazo [PDF]

, 2002
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em Neurociências.Determinação dos efeitos de diferentes períodos de isolamento sobre o comportamento social do indivíduo, procurando
Rau, Débora Driemeyer Wilbert
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