Results 51 to 60 of about 328,019 (196)

Establishment of Humanized EFNB2/B3 Murine Models for Investigating Nipah Virus Pathogenesis

Animal Research and One Health, EarlyView.
ABSTRACT Nipah virus (NiV) is a zoonotic paramyxovirus classified as a WHO priority pathogen, which causes severe respiratory disease and encephalitis in humans with high mortality. Currently, no licensed vaccines or specific antiviral therapies are available.
Wei Dong, Ning Liu, Weining Kong, Xiang Gao, Feifei Guan, Shan Gao, Yuanwu Ma   +6 more
wiley   +1 more source

Modulatory effects of rutin on biochemical and hematological parameters in hypercholesterolemic Golden Syrian hamsters

Anais da Academia Brasileira de Ciências, 2009
Flavonoids have been reported to exhibit several pharmacological properties, mainly in cardiovascular and inflammatory diseases. In the present study, we observed that rutin, a known glycosylated flavonoid isolated from Dimorphandra mollis, had a ...
Alexandre Kanashiro, Daiani C.O. Andrade, Luciana M. Kabeya, Walter M. Turato, Lucia H. Faccioli, Sérgio A. Uyemura, Yara M. Lucisano-Valim   +6 more
doaj   +1 more source

CardiLect: A combined cross‐species lectin histochemistry protocol for the automated analysis of cardiac remodelling

ESC Heart Failure, Volume 12, Issue 2, Page 1398-1415, April 2025.
Abstract Background Cardiac remodelling, a crucial aspect of heart failure, is commonly investigated in preclinical models by quantifying cardiomyocyte cross‐sectional area (CSA) and microvascular density (MVD) via histological methods, such as immunohistochemistry.
Tamás G. Gergely, Tamás Kovács, Andrea Kovács, Viktória E. Tóth, Nabil V. Sayour, Gábor M. Mórotz, Csenger Kovácsházi, Gábor B. Brenner, Zsófia Onódi, Balázs Enyedi, Domokos Máthé, Przemyslaw Leszek, Zoltán Giricz, Péter Ferdinandy, Zoltán V. Varga   +14 more
wiley   +1 more source

Generating golden Syrian hamsters with conditional alleles via zygote microinjection of CRISPR/Cas9

Animal Models and Experimental Medicine
Background The golden Syrian hamster is a valuable animal model for studying carcinogenesis, metabolic disorders, cardiovascular diseases, and viral infections due to its biological and pathological similarities to humans.
Wei Chen, Xu Zhang, Rui Fan, Xia Li, Feifei Guan, Gefan Wan, Weining Kong, Xiaolong Qi, Shuo Pan, Sijing Shi, Yuanlong Su, Shan Gao, Wei Huang, Xunde Xian, Jiangning Liu, Yuhui Wang, Yuanwu Ma   +16 more
doaj   +1 more source

A Comprehensive Study to Compare Different Compound Representations for Predicting Carcinogenicity In Vivo

Journal of Applied Toxicology, EarlyView.
ABSTRACT Carcinogenicity evaluation is a critical component of chemical risk assessment, yet traditional in vivo testing remains time consuming, costly, and ethically challenging. Computational approaches based on machine learning offer promising alternatives, but the relative contributions of different molecular representation strategies for ...
Iuri Barbosa Pereira, Rogerio Salvini, Eloisa Dutra Caldas   +2 more
wiley   +1 more source

Vasculitis and Neutrophil Extracellular Traps in Lungs of Golden Syrian Hamsters With SARS-CoV-2

Frontiers in Immunology, 2021
Neutrophil extracellular traps (NETs) have been identified as one pathogenetic trigger in severe COVID-19 cases and therefore well-described animal models to understand the influence of NETs in COVID-19 pathogenesis are needed.
Kathrin Becker, Georg Beythien, Nicole de Buhr, Nicole de Buhr, Stephanie Stanelle-Bertram, Berfin Tuku, Nancy Mounogou Kouassi, Sebastian Beck, Martin Zickler, Lisa Allnoch, Gülsah Gabriel, Gülsah Gabriel, Maren von Köckritz-Blickwede, Maren von Köckritz-Blickwede, Wolfgang Baumgärtner   +14 more
doaj   +1 more source

Gymnema sylvestre: Bioactive constituents, health benefits, and emerging applications in nutraceuticals and functional foods

JSFA reports, EarlyView.
Abstract Gymnema sylvestre (Retz.) R.Br. ex‐Schult., commonly known as “gurmar” or “sugar destroyer,” belongs to the Apocynaceae family and is traditionally used in Ayurveda for diabetes management. This review synthesizes ethnomedicinal evidence with contemporary pharmacological studies, to evaluate the therapeutic properties and mechanistic actions ...
Faiza Saeed, Muhammad Tauseef Sultan, Hassan Raza, Ahmad Mujtaba Noman, Nimra Haroon, Entessar Mohammad Al Jbawi   +5 more
wiley   +1 more source

ABCA1 deficiency‐induced cholesterol accumulation aggravates colonic epithelial injury in knockout hamsters

Animal Models and Experimental Medicine, Volume 9, Issue 10, Page 2063-2074, October 2026.
We established ABCA1‐knockout Syrian golden hamsters as a novel and physiologically relevant model for colitis research. When challenged with a high‐fat diet, ABCA1‐deficient hamsters developed exacerbated colonic inflammation and impaired mucosal barrier integrity, driven by intracellular cholesterol accumulation.
Chang Liu, Jingjie Zheng, Sijing Shi, Jianwen Chen, Geroge Liu, Wei Huang, Xunde Xian, Yuhui Wang, Jianglin Fan, Ping Zhu, Xiawen Yang   +10 more
wiley   +1 more source

A note on the use of the isolated stomach preparation of the Syrian golden hamster

, 1966
The sensitivity of the isolated stomach strip of the Syrian golden hamster to some neurohormones has been assessed. Acetylcholine (5 × 10−9 g/ml), histamine (10−8 g/ml), bradykinin (10−9 g/ml) and angiotensin (10−9 g/ml) contracted the preparation.
E MIKOŚ
core   +1 more source

Protective effect of coumarin on cell surface glycoconjugates abnormalities during 7,12-dimethylbenz(a)anthracene (DMBA) induced oral carcinogenesis [PDF]

International Journal of Biological and Medical Research, 2011
Aims: The major aims of the present study was to focus the protective effect of coumarin on cell surface glycoconjugates abnormalities during 7,12-dimethylbenz(a)anthracene (DMBA) induced hamster buccal pouch carcinogenesis. Methods: DMBA painting in the
Nagarethinam Baskaran, Shanmugam Manoharan, Simon Silvan, Duraisamy Palanimuthu,Duraisamy Rajasekaran, Murugaraj Manoj Prabhakar, Sekar Karthikeyan,Ramachandran Srinivasan and Shamsul Afaq Wani   +2 more
doaj