Results 1 to 10 of about 352,015 (307)

Vesicular and non-vesicular transport feed distinct glycosylation pathways in the Golgi. [PDF]

Nature, 2013
Newly synthesized proteins and lipids are transported across the Golgi complex via different mechanisms whose respective roles are not completely clear. We previously identified a non-vesicular intra-Golgi transport pathway for glucosylceramide (GlcCer)--
Burke JE, Capuani F, Chuang CC, D'Angelo G, D'Auria S, Daniele T, DE MATTEIS, Maria Antonietta, Di Tullio G, Harada A, Johannes L, Mattjus P, MONTI, MARIA, Ohvo Rekilä H, Platt FM, Polishchuk E, PUCCI, PIETRO, Santoro M, Sato T, Uemura T, Varriale A, Williams RL   +20 more
core   +3 more sources

Super-resolution microscopy reveals a Rab6a-dependent trafficking hub for rhodopsin at the mammalian rod photoreceptor Golgi [PDF]

Biology Open
Maryam Hekmatara, Samantha L. Thompson, Kristen N. Haggerty, Sydney Hagen, Brooke A. Brothers, Bali Daniels, Guillaume Luxardi, Ala Moshiri, Wen-Tao Deng, Michael A. Robichaux   +9 more
doaj   +2 more sources

Rsp5 Ubiquitin Ligase Is Required for Protein Trafficking in Saccharomyces cerevisiae COPI Mutants [PDF]

, 2012
Retrograde trafficking from the Golgi to the endoplasmic reticulum (ER) depends on the formation of vesicles coated with the multiprotein complex COPI.
Jarmoszewicz, Katarzyna, Kaminska, Joanna, Riezman, Howard, Łukasiak, Katarzyna   +3 more
core   +30 more sources

GRASPing the unconventional secretory machinery to bridge cellular stress signaling to the extracellular proteome

Cell Stress, 2021
Cellular adaptation to stress is a crucial homeostatic process for survival, metabolism, physiology, and disease. Cells respond to stress stimuli (e.g., nutrient starvation, growth factor deprivation, hypoxia, low energy, etc.) by changing the activity ...
Constantinos Demetriades, Julian Nüchel, Markus Plomann   +2 more
doaj   +1 more source

Golgi Biogenesis [PDF]

Cold Spring Harbor Perspectives in Biology, 2011
The Golgi is an essential membrane-bound organelle in the secretary pathway of eukaryotic cells. In mammalian cells, the Golgi stacks are integrated into a continuous perinuclear ribbon, which poses a challenge for the daughter cells to inherit this membrane organelle during cell division.
Yanzhuang, Wang, Joachim, Seemann
openaire   +2 more sources

Src activates retrograde membrane traffic through phosphorylation of GBF1

eLife, 2021
The Src tyrosine kinase controls cancer-critical protein glycosylation through Golgi to ER relocation of GALNTs enzymes. How Src induces this trafficking event is unknown.
Joanne Chia, Shyi-Chyi Wang, Sheena Wee, David James Gill, Felicia Tay, Srinivasaraghavan Kannan, Chandra S Verma, Jayantha Gunaratne, Frederic A Bard   +8 more
doaj   +1 more source

Rab1 interacts with GOLPH3 and controls Golgi structure and contractile ring constriction during cytokinesis in Drosophila melanogaster [PDF]

Open Biology, 2017
Cytokinesis requires a tight coordination between actomyosin ring constriction and new membrane addition along the ingressing cleavage furrow. However, the molecular mechanisms underlying vesicle trafficking to the equatorial site and how this process is
Stefano Sechi, Anna Frappaolo, Roberta Fraschini, Luisa Capalbo, Marco Gottardo, Giorgio Belloni, David M. Glover, Alan Wainman, Maria Grazia Giansanti   +8 more
doaj   +1 more source

Cdc42 regulates cytokine expression and trafficking in bronchial epithelial cells

Frontiers in Immunology, 2022
Airway epithelial cells can respond to incoming pathogens, allergens and stimulants through the secretion of cytokines and chemokines. These pro-inflammatory mediators activate inflammatory signaling cascades that allow a robust immune response to be ...
Rowayna Shouib, Gary Eitzen
doaj   +1 more source

Estimating the potential for dementia prevention through modifiable risk factors elimination in the real-world setting: a population-based study

Alzheimer’s Research & Therapy, 2020
Background Preventing dementia onset is one of the global public health priorities: around 35% of dementia cases could be attributable to modifiable risk factors.
Elena Rolandi, Daniele Zaccaria, Roberta Vaccaro, Simona Abbondanza, Laura Pettinato, Annalisa Davin, Antonio Guaita   +6 more
doaj   +1 more source

Up-regulation of Osh6 boosts an anti-aging membrane trafficking pathway toward vacuoles

Microbial Cell, 2022
Members of the family of oxysterol-binding proteins mediate non-vesicular lipid transport between membranes and contribute to longevity in different manners.
Ilham Kadhim, Nazneen Begum, William King, Licheng Xu, Fusheng Tang   +4 more
doaj   +1 more source