Angewandte Chemie - International Edition, 2021 Golgi apparatus is emerging as a key signaling hub of cells and an important target for cancer therapy, but there are few approaches for targeting Golgi and selectively killing cancer cells.
Jiaqing Wang, Hongjian He, Meihui Yi
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Adaptation of the Golgi Apparatus in Cancer Cell Invasion and Metastasis
Frontiers in Cell and Developmental Biology, 2021 The Golgi apparatus plays a central role in normal cell physiology by promoting cell survival, facilitating proliferation, and enabling cell-cell communication and migration.
Sarah Bui +5 more
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The Golgi apparatus in neurorestoration [PDF]
Journal of Neurorestoratology, 2019 The central role of the Golgi apparatus in critical cellular processes such as the transport, processing, and sorting of proteins and lipids has placed it at the forefront of cell science.
Jianyang Liu +5 more
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Ubiquitin-mediated degradation at the Golgi apparatus [PDF]
Frontiers in Molecular Biosciences, 2023 The Golgi apparatus is an essential organelle of the secretory pathway in eukaryotic cells. It processes secretory and transmembrane proteins and orchestrates their transport to other endomembrane compartments or the plasma membrane.
Lana Buzuk, Doris Hellerschmied
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The endoplasmic reticulum-resident chaperone heat shock protein 47 protects the Golgi apparatus from the effects of O-glycosylation inhibition. [PDF]
PLoS ONE, 2013 The Golgi apparatus is important for the transport of secretory cargo. Glycosylation is a major post-translational event. Recognition of O-glycans on proteins is necessary for glycoprotein trafficking.
Shingo Miyata +4 more
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The effects of WWP1 overexpression on the golgi apparatus stress response and proteoglycan production in adipocytes [PDF]
Scientific ReportsWhite adipocytes are a major component of white adipose tissue (WAT) and help to maintain systemic metabolic homeostasis by storing energy and secreting adipokines. In mice deficient in the protein WWP1 (WW domain-containing E3 ubiquitin protein ligase 1)
Yuka Nozaki +8 more
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The centrosome–Golgi apparatus nexus [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2014 A shared feature among all microtubule (MT)-dependent processes is the requirement for MTs to be organized in arrays of defined geometry. At a fundamental level, this is achieved by precisely controlling the timing and localization of the nucleation ...
R. Rios
semanticscholar +5 more sources
Characterization of lipoprotein particles isolated from the Golgi apparatus of rat liver
Journal of Lipid Research, 1969 It has been proposed that particles within tubules and vesicles of the Golgi apparatus of liver cells are precursors of very low density lipoproteins in blood plasma. To characterize these particles we isolated a cell fraction rich in Golgi apparatus and
Robert W. Mahley +2 more
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Characterization of the glutathione redox state in the Golgi apparatus [PDF]
Redox BiologyRedox homeostasis is crucial for cell function, and, in eukaryotic cells, studying it in a compartmentalized way is essential due to the redox variations between different organelles.
Carla Miró-Vinyals +5 more
doaj +3 more sources
RNAi screening reveals a large signaling network controlling the Golgi apparatus in human cells
Molecular Systems Biology, 2012 The Golgi apparatus has many important physiological functions, including sorting of secretory cargo and biosynthesis of complex glycans. These functions depend on the intricate and compartmentalized organization of the Golgi apparatus.
Joanne Chia +5 more
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