Results 11 to 20 of about 957,365 (341)

MARK2 regulates Golgi apparatus reorientation by phosphorylation of CAMSAP2 in directional cell migratio [PDF]

eLife
The reorientation of the Golgi apparatus is crucial for cell migration and is regulated by multipolarity signals. A number of non-centrosomal microtubules anchor at the surface of the Golgi apparatus and play a vital role in the Golgi reorientation, but ...
Peipei Xu, Rui Zhang, Zhengrong Zhou, Honglin Xu, Yuejia Li, Mengge Yang, Ruifan Lin, Yingchun Wang, Xiahe Huang, Qi Xie, Wenxiang Meng   +10 more
doaj   +2 more sources

The organization and function of the Golgi apparatus in dendrite development and neurological disorders [PDF]

Genes and Diseases, 2023
Dendrites are specialized neuronal compartments that sense, integrate and transfer information in the neural network. Their development is tightly controlled and abnormal dendrite morphogenesis is strongly linked to neurological disorders.
Meilan Chen, Lu Xu, Yi Wu, Peter Soba, Chun Hu   +4 more
doaj   +2 more sources

Golgi Apparatus Target Proteins in Gastroenterological Cancers: A Comprehensive Review of GOLPH3 and GOLGA Proteins [PDF]

Cells, 2023
The Golgi apparatus plays a central role in protein sorting, modification and trafficking within cells; its dysregulation has been implicated in various cancers including those affecting the GI tract.
Sandica Bucurica, Laura Gaman, Mariana Jinga, Andrei Adrian Popa, Florentina Ionita-Radu   +4 more
doaj   +2 more sources

A Golgi apparatus‑related subtype and risk signature predicts prognosis and evaluates immunotherapy response in gastric cancer [PDF]

Discover Oncology
Background Gastric cancer (GC) remains a significant health burden, calling for the discovery of novel biomarkers. Golgi apparatus, a crucial cellular organelle involved in tumorigenesis, remains underexplored in GC research.
Ruyue Chen, Zengwu Yao, Lixin Jiang, Jinchen Hu   +3 more
doaj   +2 more sources

Biogenesis of specialized lysosomes in differentiated keratinocytes relies on close apposition with the Golgi apparatus [PDF]

Cell Death and Disease
Intracellular organelles support cellular physiology in diverse conditions. In the skin, epidermal keratinocytes undergo differentiation with gradual changes in cellular physiology, accompanying remodeling of lysosomes and the Golgi apparatus.
Sarmistha Mahanty, Ptissam Bergam, Vivek Belapurkar, Litralson Eluvathingal, Nikita Gupta, Bruno Goud, Deepak Nair, Graça Raposo, Subba Rao Gangi Setty   +8 more
doaj   +2 more sources

GolpHCat (TMEM87A), a unique voltage-dependent cation channel in Golgi apparatus, contributes to Golgi-pH maintenance and hippocampus-dependent memory [PDF]

Nature Communications
Impaired ion channels regulating Golgi pH lead to structural alterations in the Golgi apparatus, such as fragmentation, which is found, along with cognitive impairment, in Alzheimer’s disease.
Hyunji Kang, Ah-reum Han, Aihua Zhang, Heejin Jeong, Wuhyun Koh, Jung Moo Lee, Hayeon Lee, Hee Young Jo, Miguel A. Maria-Solano, Mridula Bhalla, Jea Kwon, Woo Suk Roh, Jimin Yang, Hyun Joo An, Sun Choi, Ho Min Kim, C. Justin Lee   +16 more
doaj   +2 more sources

H5 subtype avian influenza virus induces Golgi apparatus stress response via TFE3 pathway to promote virus replication. [PDF]

PLoS Pathogens
During infection, avian influenza virus (AIV) triggers endoplasmic reticulum (ER) stress, a well-established phenomenon in previous research. The Golgi apparatus, situated downstream of the ER and crucial for protein trafficking, may be impacted by AIV ...
Yuncong Yin, Xianjin Kan, Xinyu Miao, Yingjie Sun, Sujuan Chen, Tao Qin, Chan Ding, Daxin Peng, Xiufan Liu   +8 more
doaj   +2 more sources

The Preparation of Golgi Apparatus-Targeted Polymer Dots Encapsulated with Carbon Nanodots of Bright Near-Infrared Fluorescence for Long-Term Bioimaging

Molecules, 2023
As a vital organelle in eukaryotic cells, the Golgi apparatus is responsible for processing and transporting proteins in cells. Precisely monitoring the status of the Golgi apparatus with targeted fluorescence imaging technology is of enormous importance
Yiping Lu, Wei Song, Zhiquan Tang, Wenru Shi, Shumei Gao, Jun Wu, Yuan Wang, Hu Pan, Yangang Wang, Hong Huang   +9 more
doaj   +1 more source

The role of the Golgi apparatus in disease (Review)

International Journal of Molecular Medicine, 2021
The Golgi apparatus is known to underpin many important cellular homeostatic functions, including trafficking, sorting and modifications of proteins or lipids.
Jianyang Liu, Yan Huang, Ting-Bo Li, Zheng Jiang, L. Zeng, Zhiping Hu   +5 more
semanticscholar   +1 more source

Maintaining Golgi Homeostasis: A Balancing Act of Two Proteolytic Pathways

Cells, 2022
The Golgi apparatus is a central hub for cellular protein trafficking and signaling. Golgi structure and function is tightly coupled and undergoes dynamic changes in health and disease.
Ron Benyair, Avital Eisenberg-Lerner, Yifat Merbl   +2 more
doaj   +1 more source