Adaptation of the Golgi Apparatus in Cancer Cell Invasion and Metastasis
Frontiers in Cell and Developmental Biology, 2021 The Golgi apparatus plays a central role in normal cell physiology by promoting cell survival, facilitating proliferation, and enabling cell-cell communication and migration.
Sarah Bui +5 more
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The endoplasmic reticulum-resident chaperone heat shock protein 47 protects the Golgi apparatus from the effects of O-glycosylation inhibition. [PDF]
PLoS ONE, 2013 The Golgi apparatus is important for the transport of secretory cargo. Glycosylation is a major post-translational event. Recognition of O-glycans on proteins is necessary for glycoprotein trafficking.
Shingo Miyata +4 more
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Human Rhinovirus 16 Causes Golgi Apparatus Fragmentation without Blocking Protein Secretion [PDF]
Journal of Virology, 2014 The replication of picornaviruses has been described to cause fragmentation of the Golgi apparatus that blocks the secretory pathway. The inhibition of major histocompatibility complex class I upregulation and cytokine, chemokine and interferon secretion
Guedan, A +7 more
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The centrosome–Golgi apparatus nexus [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2014 A shared feature among all microtubule (MT)-dependent processes is the requirement for MTs to be organized in arrays of defined geometry. At a fundamental level, this is achieved by precisely controlling the timing and localization of the nucleation events that give rise to new MTs. To this end, MT nucleation is restricted to specific subcellular sites
R. Rios
openaire +4 more sources
H5 subtype avian influenza virus induces Golgi apparatus stress response via TFE3 pathway to promote virus replication. [PDF]
PLoS PathogensDuring infection, avian influenza virus (AIV) triggers endoplasmic reticulum (ER) stress, a well-established phenomenon in previous research. The Golgi apparatus, situated downstream of the ER and crucial for protein trafficking, may be impacted by AIV ...
Yuncong Yin +8 more
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GolpHCat (TMEM87A), a unique voltage-dependent cation channel in Golgi apparatus, contributes to Golgi-pH maintenance and hippocampus-dependent memory [PDF]
Nature CommunicationsImpaired ion channels regulating Golgi pH lead to structural alterations in the Golgi apparatus, such as fragmentation, which is found, along with cognitive impairment, in Alzheimer’s disease.
Hyunji Kang +16 more
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Spatiotemporal dissection of the Golgi apparatus and the ER-Golgi intermediate compartment in budding yeast. [PDF]
ElifeTojima T +4 more
europepmc +2 more sources
Molecules, 2023 As a vital organelle in eukaryotic cells, the Golgi apparatus is responsible for processing and transporting proteins in cells. Precisely monitoring the status of the Golgi apparatus with targeted fluorescence imaging technology is of enormous importance
Yiping Lu +9 more
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Maintaining Golgi Homeostasis: A Balancing Act of Two Proteolytic Pathways
Cells, 2022 The Golgi apparatus is a central hub for cellular protein trafficking and signaling. Golgi structure and function is tightly coupled and undergoes dynamic changes in health and disease.
Ron Benyair +2 more
doaj +1 more source