A SNARE geranylgeranyltransferase essential for the organization of the Golgi apparatus
EMBO Journal, 2020 Protein prenylation is essential for many cellular processes including signal transduction, cytoskeletal reorganization, and membrane trafficking. Here, we identify a novel type of protein prenyltransferase, which we named geranylgeranyltransferase type ...
R. Shirakawa +13 more
semanticscholar +1 more source
The asymmetrical structure of Golgi apparatus membranes revealed by in situ atomic force microscope. [PDF]
PLoS ONE, 2013 The Golgi apparatus has attracted intense attentions due to its fascinating morphology and vital role as the pivot of cellular secretory pathway since its discovery.
Haijiao Xu +5 more
doaj +1 more source
C11ORF24 is a novel type I membrane protein that cycles between the Golgi apparatus and the plasma membrane in Rab6-positive vesicles. [PDF]
PLoS ONE, 2013 The Golgi apparatus is an intracellular compartment necessary for post-translational modification, sorting and transport of proteins. It plays a key role in mitotic entry through the Golgi mitotic checkpoint. In order to identify new proteins involved in
Vincent Fraisier +12 more
doaj +1 more source
An OBSL1-Cul7Fbxw8 ubiquitin ligase signaling mechanism regulates Golgi morphology and dendrite patterning. [PDF]
PLoS Biology, 2011 The elaboration of dendrites in neurons requires secretory trafficking through the Golgi apparatus, but the mechanisms that govern Golgi function in neuronal morphogenesis in the brain have remained largely unexplored.
Nadia Litterman +7 more
doaj +1 more source
Copy number variants suggest different molecular pathways for the pathogenesis of bladder exstrophy
American Journal of Medical Genetics Part A, Volume 191, Issue 2, Page 378-390, February 2023., 2023 Abstract Bladder exstrophy is a rare congenital malformation leaving the urinary bladder open in the midline of the abdomen at birth. There is a clear genetic background with chromosome aberrations, but so far, no consistent findings apart from 22q11‐duplications detected in about 2%–3% of all patients.
Agneta Nordenskjöld +9 more
wiley +1 more source
Acid digestion and symbiont: Proton sharing at the origin of mitochondriogenesis?
BioEssays, Volume 45, Issue 1, January 2023., 2023 ADMit hypothesis for the origin of eukaryotes. A bacterial symbiont became associated with a protophagocytic host that captured prey with membrane processes. The symbiont cooperated to kill and digest the prey with reactive oxygen species and the acidification of the microenvironment.
Mario Mencía
wiley +1 more source
Decoupling polarization of the Golgi apparatus and GM1 in the plasma membrane.
PLoS ONE, 2013 Cell polarization is a process of coordinated cellular rearrangements that prepare the cell for migration. GM1 is synthesized in the Golgi apparatus and localized in membrane microdomains that appear at the leading edge of polarized cells, but the ...
Blaine Bisel +3 more
doaj +1 more source
Cytoplasmic dynein and its regulatory proteins in Golgi pathology in nervous system disorders
Frontiers in Neuroscience, 2015 The Golgi apparatus is a dynamic organelle involved in processing and sorting of lipids and proteins. In neurons, the Golgi apparatus is important for the development of axons and dendrites and maintenance of their highly polarized morphology.
Dick eJaarsma, Casper eHoogenraad
doaj +1 more source
Retro-2 alters Golgi structure
Scientific Reports, 2022 Retro-2 directly interacts with an ER exit site protein, Sec16A, inhibiting ER exit of a Golgi tSNARE, Syntaxin5, which results in rapid re-distribution of Syntaxin5 to the ER. Recently, it was shown that SARS-CoV-2 infection disrupts the Golgi apparatus
Xihua Yue +7 more
doaj +1 more source
A model for the self-organization of vesicular flux and protein distributions in the Golgi apparatus [PDF]
PLoS Comput Biol 9(7): e1003125. (2013), 2013 The generation of two non-identical membrane compartments via exchange of vesicles is considered to require two types of vesicles specified by distinct cytosolic coats that selectively recruit cargo and two membrane-bound SNARE pairs that specify fusion and differ in their affinities for each type of vesicles. The mammalian Golgi complex is composed of
arxiv +1 more source