Golgi Oncoprotein GOLPH3 Gene Expression is Regulated by Functional E2F and CREB/ATF Promoter Elements [PDF]
, 2019 The Golgi organelle duplicates its protein and lipid content to segregate evenly between two daughter cells after mitosis. However, how Golgi biogenesis is regulated during interphase remains largely unknown.
Field, Seth J. +6 more
core +3 more sources
Phosphoinositide Metabolism: Biochemistry, Physiology and Genetic Disorders
Journal of Inherited Metabolic Disease, Volume 48, Issue 2, March 2025.ABSTRACT Phosphatidylinositol, a glycerophospholipid with a myo‐inositol head group, can form seven different phosphoinositides (PItds) by phosphorylation at inositol carbons 3, 4 and/or 5. Over 50 kinases and phosphatases participate in PItd metabolism, creating an interconnected PItd network that allows for precise temporal and spatial regulation of ...
Francis Rossignol +2 more
wiley +1 more source
Organelle‐Targeting Nanoparticles
Advanced Science, Volume 12, Issue 7, February 17, 2025.This review examines nanoparticle‐based therapies targeting organelles like the nucleus, mitochondria, and lysosomes. Nanoparticle design, targeting strategies, and their applications in treating diseases linked to organelle dysfunction are discussed, highlighting the potential for improved treatment outcomes and reduced off‐target effects.
John Soukar +2 more
wiley +1 more source
Lentivirus Mediated GOLPH3 shRNA Inhibits Growth and Metastasis of Esophageal Squamous Cancer
Asian Pacific Journal of Cancer Prevention, 2013 To investigate the role of Golgi phosphoprotein 3 (GOLPH3) in tumour growth and metastasis of esophageal squamous cancer.A lentiviral shRNA-vector was utilized to stably knockdown GOLPH3 in Eca-109 esophageal squamous cancer cells. mRNA transcription and protein expression of GOLPH3 were examined by real-time quantitative PCR and Western blotting ...
Qiang, Wang, Xian, Wang, Can-Bin, Zhang
openaire +3 more sources
Supplementary Figure 2 from Overexpression of GOLPH3 Promotes Proliferation and Tumorigenicity in Breast Cancer via Suppression of the FOXO1 Transcription Factor [PDF]
, 2023 Zhao-Lei Zeng +8 more
openalex +2 more sources
Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration [PDF]
, 2014 Mutations in the vacuolar protein sorting 35 homolog (VPS35) gene at the PARK17 locus, encoding a key component of the retromer complex, were recently identified as a new cause of late-onset, autosomal dominant Parkinson's disease (PD).
A. Fiser +38 more
core +5 more sources
Overexpression of GOLPH3 is associated with poor survival in non-small-cell lung cancer [PDF]
, 2016 As a highly conserved protein of the Golgi apparatus, Golgi phosphoprotein 3 (GOLPH3) has been shown to be involved in tumorigenesis. This study aims to explore the expression and significance of GOLPH3 in non-small-cell lung cancer (NSCLC).
Chen, D +10 more
core
Supplementary Figure 6 from Overexpression of GOLPH3 Promotes Proliferation and Tumorigenicity in Breast Cancer via Suppression of the FOXO1 Transcription Factor [PDF]
, 2023 Zhao-Lei Zeng +8 more
openalex +2 more sources
Zhongguo shiyan zhenduanxue, 2022 目的 探讨高尔基体磷酸化蛋白3（GOLPH3）、血管内皮生长因子（VEGF）在胃癌组织中的表达情况及其临床意义。方法 选取2018年2月—2019年3月于河北北方学院附属第一医院行胃癌根治性切除手术的103例患者作为研究对象，分析所选患者的临床资料，收集其胃癌组织及癌旁组织。比较不同TNM分期、浸润深度、分化程度、淋巴结转移胃癌患者GOLPH3、VEGF表达情况。结果胃癌组织GOLPH3、VEGF阳性表达率分别为66.02%、58.25%，均高于癌旁组织的19.42%、23.30%（P＜0.05 ...
王锐 +6 more
doaj
A novel coordinated function of Myosin II with GOLPH3 controls centralspindlin localization during cytokinesis in Drosophila [PDF]
, 2020 Stefano Sechi +4 more
openalex +1 more source