Results 141 to 150 of about 1,450 (167)

Development of a Golgi-targeted superoxide anion fluorescent probe for elucidating protein GOLPH3 function in myocardial ischemia-reperfusion injury.

Analytica Chimica Acta, 2023
Superoxide anion (O2•-) is an important reactive oxygen species (ROS) and participates in various physiological and pathological processes in the organism. The O2•- burst induced by ischemia-reperfusion (I/R) is associated with cardiovascular disease and
Ao Li, Ya-lan Liu, Labapuchi, Zhe Chen, Songjiao Li, Rongbin Zhong, Dan Cheng, Linxi Chen, Longwei He   +8 more
semanticscholar   +1 more source

Regulation of the Golgi apparatus via GOLPH3-mediated new selective autophagy

Life Sciences, 2020
Although previous studies elaborated that selective autophagy was involved in quality control of some organelles, including nucleus, mitochondria, the endoplasmic reticulum and peroxisomes, it remained unclear whether the selective autophagy of the Golgi apparatus (Golgiphagy) existed or not.In this study, H9c2 cells, HUVECs, HA-VSMCs and HEK293T cells
Li-Qun, Lu, Ming-Zhu, Tang, Zhi-Hao, Qi, Shi-Fang, Huang, Yong-Qi, He, Dian-Ke, Li, Lan-Fang, Li, Lin-Xi, Chen   +7 more
openaire   +2 more sources

Golgi signalling proteins GOLPH3, MYO18A, PITPNC1 and RAB1B: implications in prognosis and survival outcomes of AML patients

Biomarkers, 2023
Background The role of different Golgi signalling proteins remains unexplored in the progression and spread of acute myeloid leukaemia (AML), whom all interact together in a way that facilitates proliferation and differentiation of myeloid lineage cells.
Y. Ali, Sara M. Radwan, Alia M. Saeed, H. El-Mesallamy   +3 more
semanticscholar   +1 more source

GOLPH3 and oncogenesis: What is the molecular link?

Tissue and Cell, 2017
The Golgi phosphoprotein 3 (GOLPH3) is encoded by a gene that is located in a region of the human genome that is often amplified in different solid tumours. GOLPH3, an evolutionary conserved phosphatidylinositol 4-phosphate (PI4P) binding protein, is mainly localised at trans Golgi network (TGN).
Rizzo Riccardo, Parashuraman Seetharaman, D'Angelo Giovanni, Luini Alberto, Luini Alberto   +4 more
openaire   +2 more sources

GOLPH3 promotes glioma progression via facilitating JAK2–STAT3 pathway activation

Journal of Neuro-Oncology, 2018
Our recent work reported that GOLPH3 promotes glioma progression via inhibiting endocytosis and degradation of EGFR. The current study aimed to explore the potential regulating mechanism of GOLPH3 on JAK2-STAT3 signaling, a downstream effector of EGFR, in glioma progression.The expression of JAK2, STAT3 and GOLPH3 in glioma tissues was detected by ...
Shishuang Wu, Jiale Fu, Yu Dong, Qinghao Yi, Dong Lu, Weibing Wang, Yanhua Qi, Rutong Yu, Xiuping Zhou   +8 more
openaire   +2 more sources

Expression and Clinical Significance of Golgi Phosphoprotein 3 (GOLPH3) in Papillary Thyroid Carcinoma

Applied immunohistochemistry & molecular morphology (Print), 2023
This study aimed to explore the correlation of Golgi phosphoprotein 3 (GOLPH3) levels in papillary thyroid carcinoma (PTC) and papillary thyroid microcarcinoma (PTMC) with clinicopathologic features.
Wai-shi Yu, Zhihua Zhou, Jianren Zeng, Zhenyi Huang, Chengzhi Qiu   +4 more
semanticscholar   +1 more source

LncRNA NORAD deficiency alleviates kidney injury in mice and decreases the inflammatory response and apoptosis of lipopolysaccharide-stimulated HK-2 cells via the miR-577/GOLPH3 axis.

Cytokine, 2022
BACKGROUND Long noncoding RNAs (lncRNAs) are significant regulators for sepsis-associated acute kidney injury (AKI). Noncoding RNA activated by DNA damage (NORAD) is highly expressed in the serum of patients with neonatal sepsis.
Zhijuan Xie, Lanji Wei, Jianying Chen, Zhong Chen   +3 more
semanticscholar   +1 more source

Inhibition of glioma growth by a GOLPH3 siRNA-loaded cationic liposomes

Journal of Neuro-Oncology, 2018
GOLPH3 has been shown to be involved in glioma proliferation. In this study, we aimed to demonstrate that GOLPH3 can serve as a target for glioma gene therapy.During the experiment, cationic liposomes with angiopep-2 (A2-CL) were used to deliver siGOLPH3 crossing the blood-brain barrier and reaching the glioma.At the cellular level, the A2-CL/siGOLPH3 ...
Zixuan Yuan, Liang Zhao, Yafei Zhang, Shun Li, Bomin Pan, Lei Hua, Zhen Wang, Chengkun Ye, Jun Lu, Rutong Yu, Hongmei Liu   +10 more
openaire   +2 more sources

Sumoylation of RAD51 upregulates GOLPH3 expression and promotes cisplatin resistance in colon cancer cells by Sp1 transcriptional activity.

Biochemical Pharmacology
Platinum-based chemotherapy is a first-line treatment for colon cancer. Previous studies have shown that Golgi phosphoprotein 3 (GOLPH3) overexpression drives platinum resistance in colon cancer and is associated with DNA damage repair (DDR).
Yuze Wu, Bingchen Lin, Zhiyong Xie, Jingshan Huang, Yi Qiu, Xiaojing Chen, Zhongshi Hong, Chengzhi Qiu   +7 more
semanticscholar   +1 more source

GOLPH3 regulates the migration and invasion of glioma cells though RhoA

Biochemical and Biophysical Research Communications, 2013
Golgi phosphoprotein 3 (GOLPH3) has been reported to be involved in the development of several human cancers. However, the biological significance of GOLPH3 in glioma progression remains largely unknown. In this study, we report, for the first time, that downregulation of GOLPH3 led to clear reductions in glioma cell migration and invasion. In addition,
Xiuping, Zhou, Wenjian, Zhan, Wenbin, Bian, Lei, Hua, Qiong, Shi, Shao, Xie, Dongxu, Yang, Yanwei, Li, Xu, Zhang, Guanzheng, Liu, Rutong, Yu   +10 more
openaire   +2 more sources