Results 191 to 200 of about 2,350 (202)

GOLPH3 promotes glioma progression via facilitating JAK2–STAT3 pathway activation

Journal of Neuro-Oncology, 2018
Our recent work reported that GOLPH3 promotes glioma progression via inhibiting endocytosis and degradation of EGFR. The current study aimed to explore the potential regulating mechanism of GOLPH3 on JAK2-STAT3 signaling, a downstream effector of EGFR, in glioma progression.The expression of JAK2, STAT3 and GOLPH3 in glioma tissues was detected by ...
Shishuang Wu, Jiale Fu, Yu Dong, Qinghao Yi, Dong Lu, Weibing Wang, Yanhua Qi, Rutong Yu, Xiuping Zhou   +8 more
openaire   +2 more sources

Golph3 promotes vascular mimicry via the epithelial mesenchymal transition in glioblastoma cells

Turkish Neurosurgery, 2021
To evaluate the relationship between Golgi phosphoprotein 3 (GOLPH3) and vasculogenic mimicry (VM) in glioblastoma cells.Glioma tissues from 40 glioma patients with different pathological grades were collected. GOLPH3 and VM were evaluated by immunostaining in glioma tissues.
Jun, Jia, Liangzhao, Chu, Xi, Zeng, Niya, Long, Minghao, Dong, Yushi, Yang, Yaxin, Hu, Jian, Liu   +7 more
openaire   +2 more sources

Inhibition of glioma growth by a GOLPH3 siRNA-loaded cationic liposomes

Journal of Neuro-Oncology, 2018
GOLPH3 has been shown to be involved in glioma proliferation. In this study, we aimed to demonstrate that GOLPH3 can serve as a target for glioma gene therapy.During the experiment, cationic liposomes with angiopep-2 (A2-CL) were used to deliver siGOLPH3 crossing the blood-brain barrier and reaching the glioma.At the cellular level, the A2-CL/siGOLPH3 ...
Zixuan Yuan, Liang Zhao, Yafei Zhang, Shun Li, Bomin Pan, Lei Hua, Zhen Wang, Chengkun Ye, Jun Lu, Rutong Yu, Hongmei Liu   +10 more
openaire   +2 more sources

GOLPH3 regulates the migration and invasion of glioma cells though RhoA

Biochemical and Biophysical Research Communications, 2013
Golgi phosphoprotein 3 (GOLPH3) has been reported to be involved in the development of several human cancers. However, the biological significance of GOLPH3 in glioma progression remains largely unknown. In this study, we report, for the first time, that downregulation of GOLPH3 led to clear reductions in glioma cell migration and invasion. In addition,
Xiuping, Zhou, Wenjian, Zhan, Wenbin, Bian, Lei, Hua, Qiong, Shi, Shao, Xie, Dongxu, Yang, Yanwei, Li, Xu, Zhang, Guanzheng, Liu, Rutong, Yu   +10 more
openaire   +2 more sources

GOLPH3 inhibits erastin‐induced ferroptosis in colorectal cancer cells

Cell Biology International
AbstractFerroptosis is a novel form of programmed cell death and is considered to be a druggable target for colorectal cancer (CRC) therapy. However, the role of ferroptosis in CRC and its underlying mechanism are not fully understood. In the present study we found that a protein enriched in the Golgi apparatus, Golgi phosphoprotein 3 (GOLPH3), was ...
Lihua Chen, Chunxiao Wang, Xiaojing Chen, Yuze Wu, Mingliang Chen, Xian Deng, Chengzhi Qiu   +6 more
openaire   +2 more sources

Study of GOLPH3: a Potential Stress-Inducible Protein from Golgi Apparatus

Molecular Neurobiology, 2014
Although the Golgi apparatus has been studied extensively for over 100 years, the complex structure-function relationships have yet to be elucidated. It is well known that the Golgi complex plays an important role in the transport, processing, sorting, and targeting of numerous proteins and lipids destined for secretion, plasma membrane, and lysosomes.
Ting, Li, Hong, You, Jie, Zhang, Xiaoye, Mo, Wenfang, He, Yang, Chen, Xiangqi, Tang, Zheng, Jiang, Ranran, Tu, Liuwang, Zeng, Wei, Lu, Zhiping, Hu   +11 more
openaire   +2 more sources

CENPK orchestrates ovarian cancer progression via GOLPH3-Mediated activation of mTOR signaling

Molecular and Cellular Endocrinology
Ovarian cancer stands as a formidable clinical challenge, with limited therapeutic options. This investigation delves into the intricate molecular mechanisms governing ovarian cancer progression and uncovers Centromere Protein K (CENPK) as a central figure in disease pathogenesis.
Gaolian Li, Jing Shen, Wenhao Cheng, Xiaoshuo Wang, Dan Wang, Yizhuo Song, Yulu Chen, Xiuming Li, Meiqi Zhang, Yuanyuan Ding, Xinhui Ma, Qilan Qian, Geng Zhang, Jing Ji, Bin Liu   +14 more
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GOLPH3‐STIP1 Complex Activates STAT3 Through Exosome Secretion to Induce Colon Cancer Metastasis

Biotechnology Journal
ABSTRACTWith a high mortality rate, colon cancer (CC) is the third most common malignant tumor worldwide. The primary causes are thought to be the high invasiveness and migration of CC cells. The functions of Golgi phosphoprotein 3 (GOLPH3), stress‐induced phosphoprotein 1 (STIP1), and the signal transducer and activator of transcription 3 (STAT3 ...
Yanta Guo, Zhongshi Hong, Sifu Huang, Yuze Wu, Chengzhi Qiu, Jianhua Xu   +5 more
openaire   +2 more sources

GOLPH3 wt Allele

2020
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GOLPH3 links the Golgi network to mTOR signaling and human cancer

Pigment Cell & Melanoma Research, 2009
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