Results 41 to 50 of about 216,147 (379)

MicroRNA-223 Suppresses IL-1β and TNF-α Production in Gouty Inflammation by Targeting the NLRP3 Inflammasome

Frontiers in Pharmacology, 2021
Introduction: MicroRNA-223 (MiR-223) serves as an important regulator of inflammatory and immune responses and is implicated in several auto-inflammatory disorders.
Quan-Bo Zhang, Quan-Bo Zhang, Dan Zhu, Dan Zhu, Dan Zhu, Fei Dai, Fei Dai, Yu-Qin Huang, Yu-Qin Huang, Jian-Xiong Zheng, Jian-Xiong Zheng, Yi-Ping Tang, Yi-Ping Tang, Zeng-Rong Dong, Zeng-Rong Dong, Xia Liao, Xia Liao, Yu-Feng Qing, Yu-Feng Qing   +18 more
doaj   +1 more source

The Efficacy and Safety of Pirfenidone Combined With Immunosuppressant Therapy in Connective Tissue Disease-Associated Interstitial Lung Disease: A 24-Week Prospective Controlled Cohort Study

Frontiers in Medicine, 2022
ObjectiveInterstitial lung disease (ILD) is a common manifestation of connective tissue disease (CTD) that manifests as several subtypes with significant differences in prognosis.
Jiaqi Wang, Jiaqi Wang, Xiao Wang, Xiao Wang, Xiaoyan Qi, Xiaoyan Qi, Zhijian Sun, Zhijian Sun, Tao Zhang, Yi Cui, Qiang Shu, Qiang Shu   +11 more
doaj   +1 more source

Disseminated cutaneous gout: a rare manifestation of a common disease [PDF]

, 2020
Disseminated cutaneous gout is a rare atypical cutaneous manifestation of gout in which widespread dermal and subcutaneous tophi develop at extra-articular body sites.
Adler, Brandon L, Crew, Ashley, DeClerck, Brittney, Guzman, Ruben, Peng, David   +4 more
core  

Identification of a Novel Mutation in a Pseudohypoparathyroidism Family

International Journal of Endocrinology, 2011
Pseudohypoparathyroidism type Ia (PHP Ia) is defined as a series of disorders characterized by multihormone resistance in end-organs and Albright hereditary osteodystrophy (AHO) phenotype.
Zhi-Min Miao, Can Wang, Bin-Bin Wang, Dong-Mei Meng, Dong-Mei Su, Zhi Cheng, Qiao-Lian Wen, Lin Han, Qing Yu, Xu Ma, Chang-Gui Li   +10 more
doaj   +1 more source

Food oral processing in humans: links between physiological parameters, release of flavour stimuli and flavour perception of food

International Journal of Food Studies, 2018
In humans, food oral processing (FOP) is the first step in the digestive process. It prepares the food for swallowing and to undergo the process of digestion.
Gilles Feron, Christian Salles
doaj   +1 more source

The Epidemiology and Genetics of Hyperuricemia and Gout across Major Racial Groups: A Literature Review and Population Genetics Secondary Database Analysis

Journal of Personalized Medicine, 2021
Gout is an inflammatory condition caused by elevated serum urate (SU), a condition known as hyperuricemia (HU). Genetic variations, including single nucleotide polymorphisms (SNPs), can alter the function of urate transporters, leading to differential HU
Faven Butler, Ali Alghubayshi, Y. Roman
semanticscholar   +1 more source

The E3 ubiquitin ligase MG53 inhibits hepatocellular carcinoma by targeting RAC1 signaling

Oncogenesis, 2022
Ras-related C3 botulinum toxin substrate 1 (RAC1) overexpressiosn and hyperactivation are correlated with aggressive growth and other malignant characteristics in a wide variety of cancers including hepatocellular carcinoma (HCC). However, the regulatory
Xiaomin Ma, Xiaoxiao Ma, Lihui Zhu, Yunxue Zhao, Mengmeng Chen, Tao Li, Yueke Lin, Dapeng Ma, Caiyu Sun, Lihui Han   +9 more
doaj   +1 more source

Common variants in the SLC28A2 gene are associated with serum uric acid level and hyperuricemia and gout in Han Chinese

Hereditas, 2019
Background Serum uric acid (SUA), hyperuricemia (HUA) and gout are complex traits with relatively high heritability. This study aims to identify whether a candidate gene, SLC28A2, exerts susceptibility for SUA fluctuation and incidence of HUA and gout in
Zhaowei Zhou, Zhiqiang Li, Can Wang, Xinde Li, Xiaoyu Cheng, Changgui Li, Yongyong Shi   +6 more
doaj   +1 more source

A study on the relationship between odor hedonic ratings and individual odor detection threshold

Scientific Reports, 2022
Odor hedonic perception (pleasant/unpleasant character) is considered as the first and one of the most prominent dimensions in olfaction and is known to depend on several parameters.
Charlotte Bontempi, Laurence Jacquot, Gérard Brand   +2 more
doaj   +1 more source

Gout Remission as a Goal of Urate-Lowering Therapy: A Critical Review

Pharmaceuticals, 2023
Urate-lowering therapies for the management of gout lead to a reduction in serum urate levels, monosodium urate crystal deposition, and the clinical features of gout, including painful and disabling gout flares, chronic gouty arthritis, and tophi.
Adwoa Dansoa Tabi-Amponsah, Sarah Stewart, Graham Hosie, Lisa K. Stamp, William J. Taylor, Nicola Dalbeth   +5 more
doaj   +1 more source