Results 41 to 50 of about 139,634 (224)

Efficacy and safety of dotinurad versus febuxostat for the treatment of gout: a randomised, multicentre, double‐blind, phase 3 trial in China

Arthritis &Rheumatology, Accepted Article.
Objectives Dotinurad is a selective urate reabsorption inhibitor that reduces serum urate levels. We compared the efficacy and safety of dotinurad with febuxostat in Chinese patients with gout. Methods This phase 3, multicentre, randomised, double‐blind, parallel‐group study randomly allocated (1:1) eligible patients with gout to receive oral dotinurad
Jia Sun, Yu Wang, Yongjing Cheng, Dongmei Guo, Jiankang Hu, Dongzhou Liu, Zhengnan Gao, Changgui Li, Yibing Lu, Xiaodan Kong, Yu Liu, Zhenyu Jiang, Bin Yi, Hongfeng Zhang, Baijie Xu, Shihao Yu, Rieko Kokan, Kohei Ishikawa, Mikiko Kawakatsu, Zhuoli Zhang   +19 more
wiley   +1 more source

Impact of gout on the risk of atrial fibrillation [PDF]

, 2016
OBJECTIVES: To examine the risk of atrial fibrillation (AF) at the time of first diagnosis of gout compared with matched controls and to follow incident gout patients and their matched controls after diagnosis to compare their subsequent risk of AF ...
Chang-Fu Kuo, Christian Mallen, De Vera, Korantzopoulos, Matthew J. Grainge, Michael Doherty, Weiya Zhang, Zhao   +7 more
core   +1 more source

ASUHAN KEPERAWATAN KELUARGA DENGAN KURANG PENGETAHUAN TENTANG REGIMEN DIET PADA ANGGOTA KELUARGA MENDERITA ASAM URAT DI DESA SUKO LEGOK RT 16 RW 6 SUKODONO SIDOARJO [PDF]

, 2016
Penyakit gout (asam urat) telah merajalela di kalangan masyarakat. Kini tidak hanya di derita oleh orang tua, tetapi juga kalangan muda. Gout primer adalah gout yang penyebabnya tidak di ketahui atau karena gangguan/kelainan proses metabolisme tubuh ...
AFARU, ILA
core  

Illness perceptions of gout patients and the use of allopurinol in primary care: baseline findings from a prospective cohort study [PDF]

, 2016
Background Patients’ perceptions of their illness are dynamic and can directly influence aspects of management. Our aim was to examine the illness perceptions of gout patients in UK primary care and associations with allopurinol use.
Belcher, J, Chandratre, P, Mallen, CD, Prior, JA, Roddy, E, Walsh, CP   +5 more
core   +1 more source

Drug–drug interaction profile of ritlecitinib as perpetrator and victim through cytochrome P450

British Journal of Clinical Pharmacology, EarlyView.
Aims To assess the effect of a potent cytochrome P450 (CYP) 3A inhibitor and CYP inducer on the pharmacokinetics of ritlecitinib, a JAK3/TEC family kinase inhibitor, and assess the effect of ritlecitinib on the pharmacokinetics of CYP substrates (midazolam, efavirenz, tolbutamide, caffeine and oral contraceptives [ethinyl oestradiol and levonorgestrel])
Vivek S. Purohit, Yeamin Huh, Martin E. Dowty, Anna Plotka, Alexandre Lejeune, Hindu Kalluru, Brian Hee   +6 more
wiley   +1 more source

First validation of the gout activity score against gout impact scale in a primary care based gout cohort [PDF]

, 2017
Objectives To validate the gout activity score (GAS) against the gout impact scale in a primary care based gout cohort. Methods This was a single-centre cross-sectional study.
Abhishek, Abhishek, Doherty, Michael, Fernandes, Gwen Sascha, Jenkins, Wendy, La-Crette, Jonathan, Valdes, Ana M.   +5 more
core   +2 more sources

Pareto in Prison

Behavioral Sciences &the Law, EarlyView.
ABSTRACT The Pareto principle is based on the concept that roughly 80% of outcomes are generated by 20% of inputs, efforts, or contributors within a group. Using a national sample of U.S. prison inmates, we examined various percentile rankings of self‐reported institutional misconduct to determine how much disorder is created behind bars by the most ...
Mark A. Morgan, Joshua S. Long, Matthew W. Logan, Frank Benton   +3 more
wiley   +1 more source

Chemical Characterization of Alphitonia neocaledonica (Schltr.) Guillaumin Bark Extract and Its Anti‐Inflammatory Activities

Chemistry &Biodiversity, EarlyView.
Study of the anti‐inflammatory activities and chemical characterization of Alphitonia neocaledonica (Schltr.) Guillaumin bark extract. ABSTRACT Alphitonia neocaledonica (Schltr.) Guillaumin is a small forest tree endemic of New Caledonia traditionally used to treat rheumatic pain and dermatoses.
Karl Huet, Philippe Georgel, Mohammed Nour, Mohamed Haddad, Edouard Hnawia, Mariko Matsui   +5 more
wiley   +1 more source

Approximating the Diameter of Planar Graphs in Near Linear Time [PDF]

, 2013
We present a $(1+\epsilon)$-approximation algorithm running in $O(f(\epsilon)\cdot n \log^4 n)$ time for finding the diameter of an undirected planar graph with non-negative edge ...
Weimann, Oren, Yuster, Raphael
core   +1 more source

The Phenolic Content and Bioactivity Assessment of Rubus sanctus Schreber Species with Potential for Food and Ethnopharmacological Uses

Chemistry &Biodiversity, EarlyView.
ABSTRACT In this study, the phytochemical content and various biological activities of Rubus sanctus Schreber species, widely distributed in Turkiye and used in folk medicine, were determined. The ethanol extracts of the root and aerial parts of the species were prepared and their bioactive phytochemical composition was identified by liquid ...
Ismail Yener
wiley   +1 more source