Results 41 to 50 of about 77,630 (206)

Role of ATP binding and hydrolysis in the gating of the cystic fibrosis transmembrane conductance regulator

Annals of Thoracic Medicine, 2012
The CFTR gene is unique within the ATP-binding cassette (ABC) protein family, predominantly of transporters, by coding a chloride channel. The gating mechanism of ABC proteins has been characterized by the ATP Switch model in terms cycles of dimer ...
Taras Gout
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Natural Changbai mineral water reduces obesity risk through regulating metabolism and gut microbiome in a hyperuricemia male mouse model

Frontiers in Nutrition
Access to clean and safe drinking water is essential. This study aimed to evaluate the effect of a kind of small molecular natural mineral water, C-cell mineral water on hyperuricemia male mice metabolism condition.
Maichao Li, Maichao Li, Maichao Li, Kai Guo, Kai Guo, Kai Guo, Yuwei He, Yuwei He, Hailong Li, Wenyan Sun, Wenyan Sun, Wenyan Sun, Xuan Yuan, Xuan Yuan, Xuan Yuan, Zhen Liu, Zhen Liu, Xinde Li, Xinde Li, Tony R. Merriman, Tony R. Merriman, Changgui Li, Changgui Li, Changgui Li, Hui Zhang, Hui Zhang, Hui Zhang   +26 more
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CX3CR1hi macrophages sustain metabolic adaptation by relieving adipose-derived stem cell senescence in visceral adipose tissue

Cell Reports, 2023
Summary: Adipose-derived stem cells (ASCs) drive healthy visceral adipose tissue (VAT) expansion via adipocyte hyperplasia. Obesity induces ASC senescence that causes VAT dysfunction and metabolic disorders.
Zixin Zhou, Huiying Zhang, Yan Tao, Haipeng Jie, Jingyuan Zhao, Jinhao Zang, Huijie Li, Yalin Wang, Tianci Wang, Hui Zhao, Yuan Li, Chun Guo, Faliang Zhu, Haiting Mao, Lining Zhang, Fengming Liu, Qun Wang   +16 more
doaj   +1 more source

The Patient Experience of Gout Remission: A Qualitative Study

ACR Open Rheumatology, 2023
Objective Preliminary remission criteria for gout have been developed. However, the patient experience of gout remission has not been described. This qualitative study aimed to understand the patient experience of gout remission and views about the ...
Adwoa Dansoa Tabi‐Amponsah, Sarah Stewart, Graham Hosie, Anne Horne, Nicola Dalbeth   +4 more
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The Role of Advanced Imaging in Gout Management

Frontiers in Immunology, 2022
Gout is a common form of inflammatory arthritis where urate crystals deposit in joints and surrounding tissues. With the high prevalence of gout, the standardized and effective treatment of gout is very important, but the long-term treatment effect of ...
Shuangshuang Li, Guanhua Xu, Junyu Liang, Liyan Wan, Heng Cao, Jin Lin   +5 more
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Gout in the spine [PDF]

Revista Brasileira de Reumatologia (English Edition), 2013
Axial gout can affect all segments of the spine. It is manifested as back pain, as pain associated with neurological symptoms, and as neurological impairment without pain in 17.9%, 75.8% and 4.2% of cases, respectively. These manifestations were the first presentation of gout in many patients.
Claudia Goldenstein-Schainberg, Eduardo Massato Hasegawa, Ricardo Fuller, Filipe Martins de Mello   +3 more
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Amplicon targeted resequencing for SLC2A9 and SLC22A12 identified novel mutations in hypouricemia subjects

Molecular Genetics & Genomic Medicine, 2019
Background To identify potential causative mutations in SLC2A9 and SLC22A12 that lead to hypouricemia or hyperuricemia (HUA). Methods Targeted resequencing of whole exon regions of SLC2A9 and SLC22A12 was performed in three cohorts of 31 hypouricemia ...
Zhaowei Zhou, Ke Wang, Juan Zhou, Can Wang, Xinde Li, Lingling Cui, Lin Han, Zhen Liu, Wei Ren, Xuefeng Wang, Keke Zhang, Zhiqiang Li, Dun Pan, Changgui Li, Yongyong Shi   +14 more
doaj   +1 more source

Artificial sweeteners differentially activate sweet and bitter gustatory neurons in Drosophila

Scientific Reports
Artificial sweeteners are highly sweet, non-nutritive compounds that have become increasingly popular over recent decades despite research suggesting that their consumption has unintended consequences. Specifically, there is evidence suggesting that some
Christian Arntsen, Jake Grenon, Isabelle Chauvel, Stéphane Fraichard, Stéphane Dupas, Jérôme Cortot, Kayla Audette, Pierre-Yves Musso, Molly Stanley   +8 more
doaj   +1 more source

Metabolomic analysis for asymptomatic hyperuricemia and gout based on a combination of dried blood spot sampling and mass spectrometry technology

Journal of Orthopaedic Surgery and Research, 2023
Background Gout is the most common inflammatory arthritis and closely related to metabolic syndrome, leading to excruciating pain and the decline in quality of patients’ life.
Shanshan Liu, Yongting Liu, Xue Wu, Zhengqi Liu   +3 more
doaj   +1 more source

Mechanisms of inflammation in gout [PDF]

Arthritis Research & Therapy, 2010
An acute attack of gout is a paradigm of acute sterile inflammation, as opposed to pyogenic inflammation. Recent studies suggest that the triggering of IL-1beta release from leucocytes lies at the heart of a cascade of processes that involves multiple cytokines and mediators.
Alexander So, Nathalie Busso
openaire   +3 more sources