Results 71 to 80 of about 48,162 (201)

Enhanced Clearance of HIV‐1 Broadly Neutralizing Antibody VRC07‐523‐LS During Viremia: Influences on Trial Design and Analysis

Clinical and Translational Science, Volume 19, Issue 2, February 2026.
ABSTRACT Broadly neutralizing antibodies (BNAb) are capable of neutralizing multiple HIV‐1 strains through the targeting of conserved epitopes. This study's objective was to quantify the pharmacokinetic (PK) parameters describing the distribution and elimination of the BNAb VRC07‐523‐LS in people with HIV (PWH), and to identify the influence of viral ...
Nicholas M. Smith, Brian M. Ho, Katharine J. Bar, Lucio Gama, Gabrielle Dziubla, Richard A. Koup, Michael Pensiero, Leonid Serebryannyy, Marina Caskey, Timothy J. Wilkin, Troy D. Wood, Gene D. Morse, Charles S. Venuto, Ray Cha, Qing Ma   +14 more
wiley   +1 more source

HIV-1 gp120 Promotes Lysosomal Exocytosis in Human Schwann Cells

Frontiers in Cellular Neuroscience, 2019
Human immunodeficiency virus type 1 (HIV-1) associated neuropathy is the most common neurological complication of HIV-1, with debilitating pain affecting the quality of life.
Gaurav Datta, Nicole M. Miller, Zahra Afghah, Jonathan D. Geiger, Xuesong Chen   +4 more
doaj   +1 more source

AFM force measurements of the gp120–sCD4 and gp120 or CD4 antigen–antibody interactions [PDF]

Biochemical and Biophysical Research Communications, 2011
Soluble CD4 (sCD4), anti-CD4 antibody, and anti-gp120 antibody have long been regarded as entry inhibitors in human immunodeficiency virus (HIV) therapy. However, the interactions between these HIV entry inhibitors and corresponding target molecules are still poorly understood.
Yong, Chen, Gucheng, Zeng, Sherry Shiyi, Chen, Qian, Feng, Zheng Wei, Chen   +4 more
openaire   +2 more sources

Chimera X Interface to Enhance Understanding in Biochemistry and Immunology

Biochemistry and Molecular Biology Education, Volume 54, Issue 1, Page 92-102, January/February 2026.
ABSTRACT Proteins are essential in biological systems, acting in transport, catalysis, and immune defense processes. However, these biomolecules' structural and functional complexity makes teaching and understanding these topics challenging. To address this difficulty, this study aimed to develop tutorials that facilitate learning and teaching about ...
Dalpiaz Giovana, Krohn Muriel Schiling, Groehs Eduarda, Anjos André da Silva, Meireles R. Mariana   +4 more
wiley   +1 more source

Single-domain antibodies and their formatting to combat viral infections [PDF]

, 2018
Since their discovery in the 1990s, single-domain antibodies (VHHs), also known as NanobodiesA (R), have changed the landscape of affinity reagents. The outstanding solubility, stability, and specificity of VHHs, as well as their small size, ease of ...
Ballegeer, Marlies, De Vlieger, Dorien, Rossey, Iebe, Saelens, Xavier, Schepens, Bert   +4 more
core   +2 more sources

Chimeric Antigen Receptor T‐Cell Therapy: More Than an Anti‐Cancer Drug

HLA, Volume 107, Issue 1, January 2026.
ABSTRACT Initially, chimeric antigen receptor (CAR) T‐cell therapy was developed to eliminate malignant B cells in haematological B‐cell malignancies by targeting CD19 and B‐cell maturation antigen. This approach achieved notable success, resulting in (malignant) B‐cell depletion and inducing clinical remission in cancer patients.
Hannah C. M. Schenk, Ilse Gille, Carolt Arana, Jordi Rovira, Eduard Palou, Fritz Diekmann, Dave L. Roelen, Mirjam H. M. Heemskerk, Sebastiaan Heidt   +8 more
wiley   +1 more source

Evaluating the neutralizing antibody response to HIV-1 membrane proximal external regional; Implications for vaccine design [PDF]

, 2014
Includes bibliographical references.Inducing broadly neutralizing antibodies targeting the HIV-1 envelope is thought to be crucial for developing an effective vaccine.
Jacob, Rajesh Abraham
core  

Simian immunodeficiency virus infection in wild-caught chimpanzees from Cameroon [PDF]

, 2005
Simian immunodeficiency viruses (SIVcpz) infecting chimpanzees (Pan troglodytes) in west central Africa are the closest relatives to all major variants of human immunodeficiency virus type 1 ([HIV-1]; groups M, N and O), and have thus been implicated as ...
Ayouba, A, Bailes, E, Barre-Sinoussi, F, Foupouapouognigni, Y F, Hahn, B H, Kfutwah, A, Muller-Trutwin, M C, Mundy, N I, Nerrienet, E, Njinku, B, Santiago, M L, Sharp, P M, Shaw, G M   +12 more
core   +2 more sources

Prevalence and Clinical Implications of HPV Infection in Oral Cavity and Oropharynx in HIV+ Men

International Journal of Dentistry, Volume 2026, Issue 1, 2026.
Introduction Human papillomavirus (HPV) is associated with several types of oral lesions (OLs), including oropharyngeal squamous cell carcinoma (SCC), especially in HIV‐positive individuals. Objectives To identify the prevalence and clinical implications of the alpha (α) and beta (β) genera of HPV in the oral cavity and oropharynx of HIV‐positive men ...
José Adán Vizcaíno-Reséndiz, Jaime F. Andrade-Villanueva, Luis Felipe Jave-Suárez, Tonatiuh Abimael Baltazar-Díaz, Felipe De Jesús Bustos-Rodríguez, Luis Eduardo Del Moral-Trinidad, Dana Alejandra Figueroa-González, Juan Carlos Vázquez-Limón, Ana Esther Mercado-González, Luz Alicia González-Hernández, Hannah Wesley   +10 more
wiley   +1 more source

The Prefusogenic Intermediate of HIV-1 gp41 Contains Exposed C-peptide Regions [PDF]

, 2003
The human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein is composed of a complex between the surface subunit gp120, which binds to cellular receptors, and the transmembrane subunit gp41.
Chan, David C., Koshiba, Takumi
core