Results 181 to 190 of about 17,335 (211)
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Receptor recognition by gp130 cytokines.
The EMBO journal, 2000Cytokines of the gp130 family exert their diverse biological effects by formation of stable high affinity transmembrane receptor complexes that are characterized by the presence of the shared transmembrane signalling receptor gp130. Different gp130 ligands form signalling complexes that vary in both composition and stoichiometry.
J, Bravo, J K, Heath
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GP130 stimulation and the maintenance of stem cells
Trends in Biotechnology, 2002Recent advantages with the cultivation of adult and embryonic stem cells have raised hopes for therapeutic applications of such cells in the treatment of neurodegenerative diseases and cancer. Cultivation of stem cells on feeder cells or treatment of the cells with cytokines is necessary to maintain stem cells in an undifferentiated state and to keep ...
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gp130-Related Cytokines and Their Receptors in the Pituitary
Trends in Endocrinology and Metabolism, 1997gp130-Related cytokines such as interleukin-6 and leukemia-inhibitory factor (LIF) act on the adenohypophysis in a paracrine manner, affecting both its differentiation and the function of specific cell types, notably the proopiomelanocortin (POMC) cells. They act on POMC cells in synergism with corticotrophin-releasing hormone, inducing ACTH secretion.
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The Cytokine Receptor gp130: Faithfully Promiscuous
Science Signaling, 2003Diverse cytokines can signal through receptor complexes containing the gp130 subunit. These cytokines, which include interleukin (IL)-6, IL-11, leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF), cardiotrophin-1 (CT-1), and CLC (cardiotrophin-like cytokine), are implicated in inflammatory and immune responses ...
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gp130: a promising drug target for cancer therapy
Expert Opinion on Therapeutic Targets, 2013Ubiquitously expressed in the human body, glycoprotein 130 (gp130) is a shared subunit of receptor complexes for at least nine cytokines (IL-6, OSM, LIF, IL-11, CNTF, CLC, IL-27, CT-1, and NP) that mediate highly diverse biological processes. Dysregulation of gp130 expression, activation, or associated signaling pathways are implicated in a variety of ...
Shili, Xu, Nouri, Neamati
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gp130-Mediated Pathway and Heart Failure
Future Cardiology, 2008Binding of ligands to gp130 activates at least three different downstream signaling pathways: the signal transducer and activator of transcription (STAT), the Src-homology tyrosine phosphatase 2-ras-MAPK and the PI3K/Akt pathways. Cardiac-specific disruption of gp130 was shown to result in heart failure in response to mechano-stress accompanied by an ...
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Update of gp130 cytokines in multiple myeloma
Current Opinion in Hematology, 1998Interleukin (IL)-6 plays a major role in the control of the survival and proliferation of myeloma cell lines and primary myeloma cells. The genes of the receptors of IL-6 have been cloned, and the major signaling pathways involved in gp130 IL-6 transducer activation have been identified.
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No inhibition of IL-27 signaling by soluble gp130
Biochemical and Biophysical Research Communications, 2005Soluble gp130 is the natural inhibitor of trans-signaling mediated by the soluble IL-6/IL-6R complex. In mouse models, recombinant sgp130 has been successfully applied for the treatment of diseases that are triggered and maintained by soluble IL-6R like Crohn's disease, peritonitis, rheumatoid arthritis, and colon cancer.
Jürgen, Scheller +4 more
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Gp130-mediated pathway and left ventricular remodeling
Journal of Cardiac Failure, 2002The binding of ligands to gp130 activates the JAK/STAT pathway, where STAT3 plays a central role in transmitting signals from the membrane to the nucleus. Cardiac-specific disruption of gp130 was shown to present heart failure in response to mechanical stress accompanied by an increase in apoptosis.
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