Results 171 to 180 of about 17,335 (211)
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Interleukin‐11: A gp130 Cytokine
Annals of the New York Academy of Sciences, 1998ABSTRACT: Interleukin (IL)‐11 is a member of the gp130 family of cytokines. Comparison of IL‐11 with another gp130 family member, IL‐6, indicates that these two cytokines share many overlapping signal transduction mechanisms. However, unlike IL‐6, treatment of patients with a recombinant human form of IL‐11 (rhIL‐11) does not increase body temperature,
William L, Trepicchio, Andrew J, Dorner
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gp130-DEPENDENT SIGNALLING PATHWAY IS NOT ENHANCED IN gp130 TRANSGENIC HEART AFTER LIF STIMULATION
Cytokine, 2000Activation of gp130 transduces a hypertrophic signal in the heart, but it is not clear whether signalling through gp130 is enhanced when gp130 is overexpressed in vivo. We generated gp130 transgenic mice (TG) and examined the activation of signalling pathways downstream of gp130 in the hearts.
E, Tone +7 more
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Requirement of gp130 signaling for the AGM hematopoiesis
Experimental Hematology, 2003Definitive hematopoiesis starts in the aorta-gonad-mesonephros (AGM) region during mouse development and remarkably expands in the liver at a later stage of ontogeny. gp130 is a signal transducing receptor component shared by all the IL-6 family cytokines, whose gene ablation in mouse results in the significant reduction in the fetal liver ...
Makiko, Takizawa +6 more
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GP130 in Human Myeloma/Plasmacytoma
1995Interleukin 6 (IL-6) is a potent growth factor for human myeloma/plasmacytoma cells (Kawano et al. 1988, Klein et al. 1989) The evidences that 1) myeloma cells produce IL-6 and express IL-6 receptor (IL-6R), 2) IL-6 augments the in vitro growth of myeloma cells, 3) anti-IL-6 antibody (Ab) or anti-IL-6R Ab inhibits their growth (Klein et al.
Y, Tani +5 more
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gp130 blockade to NOD off Crohn’s disease
Trends in Immunology, 2021In a recent publication, Nayar et al. uncover specific inflammatory cell populations associated with Crohn's disease (CD) pathogenesis, and a gp130-STAT3 signaling axis linked to disease in anti-TNF antibody treatment-refractory patients. Therefore, gp130 blockade might represent a potential CD therapy approach, perhaps in conjunction with existing ...
Tapas, Mukherjee, Dana J, Philpott
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gp130 CYTOKINE FAMILY AND BONE CELLS
Cytokine, 2000Bone tissue is continually being remodelled according to physiological circumstances. Two main cell populations (osteoblasts and osteoclasts) are involved in this process, and cellular activities (including cell differentiation) are modulated by hormones, cytokines and growth factors.
D, Heymann, A V, Rousselle
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Binding of Madindoline A to the Extracellular Domain of gp130
Biochemistry, 2005Elevated levels of IL-6 and IL-11 are associated with multiple myeloma, rheumatoid arthritis, hypercalcemia, cancer cachexia, and Castleman's disease. Madindoline A (MadA), isolated from Streptomyces nitrosporeus K93-0711, specifically inhibits the growth of IL-6- and IL-11-dependent cell lines, most likely by interfering with the homodimerization of ...
Abu Z M, Saleh +4 more
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Down-Regulation of gp130 in Nasopharyngeal Carcinoma
American Journal of Rhinology & Allergy, 2009Background The purpose of this study was to explore the expression and biological functions of glycoprotein 130 (gp130) in Epstein-Barr virus (EBV)-associated nasopharyngeal carcinoma (NPC). A prospective study was performed. Methods
Yung-Song, Lin +4 more
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2000
Cytokines are secreted multifunctional proteins, exerting local autocrine and paracrine, as well as sys- temic endocrine actions. Although originally thought to be derived from hematopoietic and immune cells, these molecules are secreted by a variety of different cell types and affect multiple target cells.
Christoph J. Auernhammer, Shlomo Melmed
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Cytokines are secreted multifunctional proteins, exerting local autocrine and paracrine, as well as sys- temic endocrine actions. Although originally thought to be derived from hematopoietic and immune cells, these molecules are secreted by a variety of different cell types and affect multiple target cells.
Christoph J. Auernhammer, Shlomo Melmed
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SOCS3 regulates the plasticity of gp130 signaling
Nature Immunology, 2003Suppressor of cytokine signaling (SOCS) proteins are feedback inhibitors of the Janus kinase (JAK) and signal transducer and activator of transcription (STAT) signaling pathway. SOCS3 is upregulated by several signals in macrophages and has been implicated as a regulator of various signaling pathways.
Roland, Lang +7 more
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