Results 101 to 110 of about 2,458 (158)

Agonism of GPBAR1 on human monocytes modulates a subset of LPS activated genes and blocks M1 differentiation.

, 2014
Monocytes from 5 donors were primed with IFNγ and stimulated with LPS ± agonist. RNA was isolated from these samples and subjected to RNA-Seq. (A) Heatmap of genes whose activation or repression by LPS at 6 hours was inhibited by the GPBAR1 agonist ...
Dimitria E. Stefanopoulos (589175), Andre Broermann (589180), F. James King (589173), Louise K. Modis (108347), Josephine Pelletier (589170), Susan M. Lukas (589172), Eugene R. Hickey (589183), Christian Harcken (589182), Donald J. Souza (589171), Jonathan D. Hill (589174), Nuruddeen D. Lewis (192385), Kelli Ryan (589176), Donna Skow (589178), Sudha Desai (589177), Lori A. Patnaude (589169), Daniel Kuzmich (589181), Stefan G. Kauschke (589179)   +16 more
core   +1 more source

Research Progress on the Mechanism and Targeted Intervention of G Protein-Coupled Bile Acid Receptor 1 (GPBAR1)-Mediated “Inflammation-Apoptosis-Metabolism-Microcirculation” Regulatory Network in Hepatitis B-Associated Liver Failure

Drug Design, Development and Therapy
Chao Cui,1 Yu Sun,2 Kaiyue Zhang,2 Jingfei Shi,3 Kai Wang,2,4 Shuai Gao4 1Scientific Research Department, Qilu Hospital of Shandong University Dezhou Hospital, Dezhou, People’s Republic of China; 2Department of Infectious Disease, Qilu Hospital of ...
Cui C, Sun Y, Zhang K, Shi J, Wang K, Gao S   +5 more
doaj  

Novel GPBAR1 agonist and RORγt inverse agonist: a dual-action approach for treating Inflammatory Bowel Diseases

Inflammatory bowel diseases (IBD), including Crohn's disease and ulcerative colitis, are chronic disorders characterized by dysregulated immune responses and persistent inflammation.
marchianò, S (via Mendeley Data), marchianò, silvia   +1 more
core   +1 more source

From Structure to Dynamics: Activation Mechanism of the G Protein-Coupled Bile Acid Receptor 1‑G_s Complex. [PDF]

ACS Omega
Fiorillo B, Moraca F, Di Leva FS, Sepe V, Fiorucci S, Limongelli V, Zampella A, Catalanotti B.   +7 more
europepmc   +1 more source

Dysregulated bile acid metabolism impairs intestinal barrier integrity via defective GPBAR1 signaling in low-birth-weight suckling piglet. [PDF]

Anim Nutr
Yin C, Xu Y, Fang W, Meng Q, Zhang W, Liu X, Tang S, Wen X, Feng X, Zhong R, Chen L, Zhang H.   +11 more
europepmc   +1 more source

How lipid ingestion is sensed: the mechanisms underlying intestinal hormone secretion. [PDF]

Clin Sci (Lond)
Santos-Hernández M, Gribble FM, Reimann F.   +2 more
europepmc   +1 more source

Research Progress on the Mechanism and Targeted Intervention of G Protein-Coupled Bile Acid Receptor 1 (GPBAR1)-Mediated "Inflammation-Apoptosis-Metabolism-Microcirculation" Regulatory Network in Hepatitis B-Associated Liver Failure. [PDF]

Drug Des Devel Ther
Cui C, Sun Y, Zhang K, Shi J, Wang K, Gao S.   +5 more
europepmc   +1 more source

From the invasive front to organotropic pre-metastatic niches: spatial immune regulatory networks governing cholangiocarcinoma dissemination and metastasis-intercepting immunotherapy. [PDF]

Front Immunol
Zhang L, Zhang K, Chen Z, Lu X.
europepmc   +1 more source

Role and progression of bile acid metabolism in mediating Th17/Treg homeostasis in inflammatory bowel disease. [PDF]

iScience
Yue S, Tan Y, Gong L, Liao F.
europepmc   +1 more source

Role of the Gut-Liver-Kidney Axis in Disease Manifestation and Biomarker Alterations. [PDF]

Int J Mol Sci
Mashima R, Ishige N.
europepmc   +1 more source