Results 141 to 150 of about 2,458 (158)
Bile acids as a "new hormone" in aging-related liver disease. [PDF]
Life MedDeng B +13 more
europepmc +1 more source
Clinical utility of an evolving cholestasis gene panel in 10,000 children and adults. [PDF]
Front PediatrHoskins BJ +5 more
europepmc +1 more source
GPBAR1 Activation by C6-Substituted Hyodeoxycholane Analogues Protect against Colitis
ACS Medicinal Chemistry Letters, 2020 GPBAR1 agonists have been identified as potential leads for the treatment of diseases related to colon inflammation such as Crohn’s and ulcerative colitis.
Cristina Di Giorgio +2 more
exaly +3 more sources
Cystathionine γ-lyase, a H2S-generating enzyme, is a GPBAR1-regulated gene and contributes to vasodilation caused by secondary bile acids [PDF]
American Journal of Physiology - Heart and Circulatory Physiology, 2015 GPBAR1 is a bile acid-activated receptor (BAR) for secondary bile acids, lithocholic (LCA) and deoxycholic acid (DCA), expressed in the enterohepatic tissues and in the vasculature by endothelial and smooth muscle cells.
Mariarosaria Bucci +2 more
exaly +2 more sources
Biochemical Pharmacology, 2023 : While patients with nonalcoholic fatty liver disease (NAFLD) are at increased risk to develop clinically meaningful cardiovascular diseases (CVD), there are no approved drug designed to target the liver and CVD component of NAFLD. GPBAR1, also known as
Michele Biagioli +2 more
exaly +2 more sources
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2-Phenoxy-nicotinamides are Potent Agonists at the Bile Acid Receptor GPBAR1 (TGR5)
ChemMedChem, 2013Rainer E Martin, Caterina Bissantz
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