ER/K linked GPCR-G protein fusions systematically modulate second messenger response in cells [PDF]
Scientific Reports, 2017 FRET and BRET approaches are well established for detecting ligand induced GPCR-G protein interactions in cells. Currently, FRET/BRET assays rely on co-expression of GPCR and G protein, and hence depend on the stoichiometry and expression levels of the ...
Rabia U. Malik +4 more
doaj +2 more sources
Bioinformatics Analysis of the Melanocortin 1 Receptor Gene (MC1R) in the Southern Platyfish Xiphophorus maculatus (Günther, 1866) [PDF]
International Journal Bioautomation, 2020 The Southern platyfish Xiphophorus maculatus is one of the most popular ornamental fish used widely as a premier model system in understanding the genetic basis of color pattern polymorphism. Coloration in X.
Abdul Khader Sultan Mohideen, Anbu Arun
doaj +1 more source
Alterations in Dendritic Spine Maturation and Neurite Development Mediated by FAM19A1
Cells, 2021 Neurogenesis and functional brain activity require complex associations of inherently programmed secretory elements that are regulated precisely and temporally.
Hyo-Jeong Yong +2 more
doaj +1 more source
LPA1-mediated inhibition of CXCR4 attenuates CXCL12-induced signaling and cell migration
Cell Communication and Signaling, 2023 Background G protein-coupled receptor heteromerization is believed to exert dynamic regulatory impact on signal transduction. CXC chemokine receptor 4 (CXCR4) and its ligand CXCL12, both of which are overexpressed in many cancers, play a pivotal role in ...
Jong Min Hong +4 more
doaj +1 more source
Scientific Reports, 2023 C-X-C chemokine receptor 4 (CXCR4) is widely overexpressed in various types of cancer and is involved in several cancer phenotypes including tumor growth, survival, and metastasis.
Chulo Park +5 more
doaj +1 more source
Heparin-bound chemokine CXCL8 monomer and dimer are impaired for CXCR1 and CXCR2 activation: implications for gradients and neutrophil trafficking [PDF]
Open Biology, 2017 Chemokine CXCL8 plays a pivotal role in host immune response by recruiting neutrophils to the infection site. CXCL8 exists as monomers and dimers, and mediates recruitment by interacting with glycosaminoglycans (GAGs) and activating CXCR1 and CXCR2 ...
Prem Raj B. Joseph +2 more
doaj +1 more source
Nuclear localization of histamine receptor 2 in primary human lymphatic endothelial cells
Biology Open, 2022 Histamine exerts its physiological functions through its four receptor subtypes. In this work, we report the subcellular localization of histamine receptor 2 (H2R), a G protein-coupled receptor (GPCR), which is expressed in a wide variety of cell and ...
Sarit Pal, Anatoliy Gashev, Debarshi Roy
doaj +1 more source
Microbial Cell, 2020 A major signal transduction pathway regulating cell growth and many associated physiological properties as a function of nutrient availability in the yeast Saccharomyces cerevisiae is the protein kinase A (PKA) pathway.
Griet Van Zeebroeck +4 more
doaj +1 more source
GPCR-OKB: the G protein coupled receptor oligomer knowledge base [PDF]
, 2010 Rapid expansion of available data about G Protein Coupled Receptor (GPCR) dimers/oligomers over the past few years requires an effective system to organize this information electronically.
Bouvier, M. +18 more
core +3 more sources
Molecular Cloning and Expression of Human Regulators of G-Protein Signaling 4, 5, and 16
McGill Journal of Medicine, 2020 N ...
Aravind Athiviraham
doaj +1 more source