G-protein-coupled receptor diversity and evolution in the closest living relatives of metazoa [PDF]
eLifeG-protein-coupled receptors (GPCRs) play a pivotal role in the perception of environmental cues across eukaryotic diversity. Although GPCRs have been relatively well characterized in metazoans, GPCR signaling is poorly understood in their sister group ...
Alain Garcia De Las Bayonas, Nicole King
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P-Rex1 limits the agonist-induced internalization of GPCRs independently of its Rac-GEF activity
Cell ReportsSummary: The guanine-nucleotide exchange factor (GEF) P-Rex1 mediates G protein-coupled receptor (GPCR) signaling by activating the small GTPase Rac. We show here that P-Rex1 also controls GPCR trafficking.
Martin J. Baker +11 more
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ACE2 interaction with cytoplasmic PDZ protein enhances SARS-CoV-2 invasion
iScience, 2021 Summary: SARS-CoV-2 is responsible for the global COVID-19 pandemic. Angiotensin converting enzyme 2 (ACE2) is the membrane-delimited receptor for SARS-CoV-2.
Qiangmin Zhang +4 more
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Bioinformatics Analysis of the Melanocortin 1 Receptor Gene (MC1R) in the Southern Platyfish Xiphophorus maculatus (Günther, 1866) [PDF]
International Journal Bioautomation, 2020 The Southern platyfish Xiphophorus maculatus is one of the most popular ornamental fish used widely as a premier model system in understanding the genetic basis of color pattern polymorphism. Coloration in X.
Abdul Khader Sultan Mohideen, Anbu Arun
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Alterations in Dendritic Spine Maturation and Neurite Development Mediated by FAM19A1
Cells, 2021 Neurogenesis and functional brain activity require complex associations of inherently programmed secretory elements that are regulated precisely and temporally.
Hyo-Jeong Yong +2 more
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LPA1-mediated inhibition of CXCR4 attenuates CXCL12-induced signaling and cell migration
Cell Communication and Signaling, 2023 Background G protein-coupled receptor heteromerization is believed to exert dynamic regulatory impact on signal transduction. CXC chemokine receptor 4 (CXCR4) and its ligand CXCL12, both of which are overexpressed in many cancers, play a pivotal role in ...
Jong Min Hong +4 more
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Scientific Reports, 2023 C-X-C chemokine receptor 4 (CXCR4) is widely overexpressed in various types of cancer and is involved in several cancer phenotypes including tumor growth, survival, and metastasis.
Chulo Park +5 more
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Heparin-bound chemokine CXCL8 monomer and dimer are impaired for CXCR1 and CXCR2 activation: implications for gradients and neutrophil trafficking [PDF]
Open Biology, 2017 Chemokine CXCL8 plays a pivotal role in host immune response by recruiting neutrophils to the infection site. CXCL8 exists as monomers and dimers, and mediates recruitment by interacting with glycosaminoglycans (GAGs) and activating CXCR1 and CXCR2 ...
Prem Raj B. Joseph +2 more
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Microbial Cell, 2020 A major signal transduction pathway regulating cell growth and many associated physiological properties as a function of nutrient availability in the yeast Saccharomyces cerevisiae is the protein kinase A (PKA) pathway.
Griet Van Zeebroeck +4 more
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Nuclear localization of histamine receptor 2 in primary human lymphatic endothelial cells
Biology Open, 2022 Histamine exerts its physiological functions through its four receptor subtypes. In this work, we report the subcellular localization of histamine receptor 2 (H2R), a G protein-coupled receptor (GPCR), which is expressed in a wide variety of cell and ...
Sarit Pal, Anatoliy Gashev, Debarshi Roy
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