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An Alternative Mode of GPCR Transactivation: Activation of GPCRs by Adhesion GPCRs. [PDF]
Int J Mol SciG protein-coupled receptors (GPCRs), critical for cellular communication and signaling, represent the largest cell surface protein family and play important roles in numerous pathophysiological processes. Consequently, GPCRs have become a primary focus in drug discovery efforts. Beyond their traditional G protein-dependent signaling pathways, GPCRs are
Lin HH.
europepmc +2 more sources
ER/K linked GPCR-G protein fusions systematically modulate second messenger response in cells [PDF]
Scientific Reports, 2017 FRET and BRET approaches are well established for detecting ligand induced GPCR-G protein interactions in cells. Currently, FRET/BRET assays rely on co-expression of GPCR and G protein, and hence depend on the stoichiometry and expression levels of the ...
Rabia U. Malik +4 more
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The Secretin GPCRs Descended from the Family of Adhesion GPCRs [PDF]
Molecular Biology and Evolution, 2008 The Adhesion G-protein-coupled receptors (GPCRs) are the most complex gene family among GPCRs with large genomic size, multiple introns, and a fascinating flora of functional domains, though the evolutionary origin of this family has been obscure. Here we studied the evolution of all class B (7tm2)-related genes, including the Adhesion, Secretin, and ...
Karl Nordström +4 more
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Bioinformatics Analysis of the Melanocortin 1 Receptor Gene (MC1R) in the Southern Platyfish Xiphophorus maculatus (Günther, 1866) [PDF]
International Journal Bioautomation, 2020 The Southern platyfish Xiphophorus maculatus is one of the most popular ornamental fish used widely as a premier model system in understanding the genetic basis of color pattern polymorphism. Coloration in X.
Abdul Khader Sultan Mohideen, Anbu Arun
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Alterations in Dendritic Spine Maturation and Neurite Development Mediated by FAM19A1
Cells, 2021 Neurogenesis and functional brain activity require complex associations of inherently programmed secretory elements that are regulated precisely and temporally.
Hyo-Jeong Yong +2 more
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LPA1-mediated inhibition of CXCR4 attenuates CXCL12-induced signaling and cell migration
Cell Communication and Signaling, 2023 Background G protein-coupled receptor heteromerization is believed to exert dynamic regulatory impact on signal transduction. CXC chemokine receptor 4 (CXCR4) and its ligand CXCL12, both of which are overexpressed in many cancers, play a pivotal role in ...
Jong Min Hong +4 more
doaj +1 more source
Acta Pharmacologica Sinica, 2012 G-protein-coupled receptors (GPCRs), which represent the largest gene family in the human genome, play a crucial role in multiple physiological functions as well as in tumor growth and metastasis. For instance, various molecules like hormones, lipids, peptides and neurotransmitters exert their biological effects by binding to these seven-transmembrane ...
Lappano R, MAGGIOLINI, Marcello
openaire +4 more sources
Scientific Reports, 2023 C-X-C chemokine receptor 4 (CXCR4) is widely overexpressed in various types of cancer and is involved in several cancer phenotypes including tumor growth, survival, and metastasis.
Chulo Park +5 more
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Heparin-bound chemokine CXCL8 monomer and dimer are impaired for CXCR1 and CXCR2 activation: implications for gradients and neutrophil trafficking [PDF]
Open Biology, 2017 Chemokine CXCL8 plays a pivotal role in host immune response by recruiting neutrophils to the infection site. CXCL8 exists as monomers and dimers, and mediates recruitment by interacting with glycosaminoglycans (GAGs) and activating CXCR1 and CXCR2 ...
Prem Raj B. Joseph +2 more
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Illuminating the life of GPCRs [PDF]
Cell Communication and Signaling, 2009 The investigation of biological systems highly depends on the possibilities that allow scientists to visualize and quantify biomolecules and their related activities in real-time and non-invasively. G-protein coupled receptors represent a family of very dynamic and highly regulated transmembrane proteins that are involved in various important ...
Annette G. Beck-Sickinger, Ilka Böhme
openaire +4 more sources