Results 231 to 240 of about 92,511 (354)

Computational Approaches for Modeling GPCR Dimerization

, 2014
Xuan-Yu Meng, Mihaly Mezei, Meng Cui
openalex   +2 more sources

Assembly of a GPCR-G Protein Complex

Cell, 2019
Yang Du, N. M. Duc, S. Rasmussen, D. Hilger, X. Kubiak, Liwen Wang, J. Bohon, H. Kim, M. Wegrecki, Awuri P Asuru, K. Jeong, Jeongmi Lee, M. Chance, D. Lodowski, B. Kobilka, K. Chung   +15 more
semanticscholar   +1 more source

Role of S1P‐ and Rho‐kinase signalling in age‐related myogenic tone deficiency in murine resistance arteries

Experimental Physiology, EarlyView.
Abstract Ageing is a risk factor for cardiovascular and neurodegenerative diseases. The myogenic response in resistance arteries is responsible for basal (myogenic) tone and blood flow autoregulation. G‐protein‐coupled receptors and G12/RhoA/Rho kinase are implicated in myogenic tone (MT), and we aimed to clarify their role in pressure sensing and ...
Gry Freja Skovsted, Alex Aupetit, Karl Björling, Kristian Agmund Haanes, Susanne Syberg, Niklas Rye Jørgensen, Blanca I. Aldana, Hirotsugu Tsuchimochi, Mark T. Waddingham, Kristine Freude, James Todd Pearson, Lars Jørn Jensen   +11 more
wiley   +1 more source

GABAB receptor‐mediated modulation of sensory neuron excitability: Roles of CaV2.2, G‐protein‐coupled inwardly rectifying potassium (GIRK) channels, and hyperpolarisation‐activated cyclic nucleotide‐gated (HCN) channels in human and mouse nociception

Experimental Physiology, EarlyView.
Abstract Chronic visceral pain is a key symptom of irritable bowel syndrome. Modulation of voltage‐gated calcium and potassium channels by G protein‐coupled receptors plays a key role in dampening nociceptive transmission. Both baclofen and the analgesic peptide α‐conotoxin Vc1.1 activate GABAB receptors (GABABR), resulting in inhibition of CaV2.2 and ...
Mariana Brizuela, Anuja R. Bony, Sonia Garcia‐Caraballo, David J. Adams, Stuart M. Brierley   +4 more
wiley   +1 more source

A yeast surface display platform for characterizing CAR T cell responses to cancer antigens. [PDF]

Nat Commun
Deichmann M, Schiesaro G, Ramanathan K, Zeeberg K, Koefoed NMT, Ormhøj M, Friis RUW, Gill RT, Hadrup SR, Jensen ED, Jensen MK.   +10 more
europepmc   +1 more source

Recent optical approaches for anatomical and functional dissection of neuron–astrocyte circuitry

The Journal of Physiology, EarlyView.
Abstract figure legend This review summarises novel optical approaches to deciphering structural and functional wiring diagrams of neuron–astrocyte circuits in the brain. There are three groups: the anatomical proximity assay, transsynaptic viral tracing and the functional connection assay. The FRET‐based neuron–astrocyte proximity assay allows mapping
Yoshiki Hatashita, Takafumi Inoue
wiley   +1 more source

Class A and B GPCRs trigger rapid Gα_s translocation to late and slow recycling endosomes. [PDF]

Commun Biol
Laniel A, Holleran B, Labonté É, Grondin SJ, Boudreault PL, Lavoie C.   +5 more
europepmc   +1 more source

Mitochondrial control of ciliary gene expression and structure in striatal neurons

The Journal of Physiology, EarlyView.
Abstract figure legend Neurons drive animal behaviour by receiving and transmitting information and require energy, primarily supplied by mitochondria, to function. Additionally, neurons need to sense environmental changes to adapt, a function that is locally played by the primary cilia.
Dogukan H. Ulgen, Alessandro Chioino, Olivia Zanoletti, Albert Quintana, Elisenda Sanz, Carmen Sandi   +5 more
wiley   +1 more source

G Protein-Coupled Receptor Signaling: Implications and Therapeutic Development Advances in Cancers. [PDF]

MedComm (2020)
Khan IR, Khurshid S, Almawash S, Kumar R, Akil ASA, Bhat AA, Macha MA.   +6 more
europepmc   +1 more source

Neoceptors: reengineering GPCRs to recognize tailored ligands

, 2007
Kenneth A. Jacobson, Zhan‐Guo Gao, Bruce T. Liang   +2 more
openalex   +2 more sources