Results 231 to 240 of about 113,722 (335)

Implication of GPRASP2 in the Proliferation and Hair Cell‐Forming of Cochlear Supporting Cells

Cell Proliferation, EarlyView.
Schematic diagram of GPRASP2‐mediated SCs proliferation and HCs formation. GPRASP2 deficiency results in increased lysosomal degradation of SMO. GPRASP2‐mediated SMO/GLI1 signalling promotes SC proliferation, which contributes to HC formation. GPRASP2‐mediated SMO/β‐catenin signalling is implicated in HCs fate specification and differentiation ...
Jing Cai, Kun Huang, Wenrui Li, Tianming Wang, Shen Yue, Zhibin Chen, Guangqian Xing, Qinjun Wei, Jun Yao, Xin Cao   +9 more
wiley   +1 more source

Macrophage Efferocytosis as a Therapeutic Strategy in Intervertebral Disc Degeneration

Cell Proliferation, EarlyView.
Macrophages, integral to degenerated intervertebral discs, play a critical role in disc degeneration. By performing efferocytosis, they clear apoptotic cells. This article explores the process of efferocytosis, its molecular mechanisms, potential therapeutic implications for intervertebral disc degeneration and future strategies for targeted treatments.
Shijie Chen, Haijun Zhang, Zhaoheng Wang, Daxue Zhu, Yanhu Li, Yizhi Zhang, Dongxin Wang, Shuwei Chen, Huan Liu, Xuewen Kang   +9 more
wiley   +1 more source

The Predicted Binding Site and Dynamics of Peptide Inhibitors to the Methuselah GPCR from Drosophila melanogaster [PDF]

, 2008
Jiyoung Heo, William W. Ja, Seymour Benzer, William A. Goddard   +3 more
openalex   +1 more source

Therapeutic and Prognostic Potential of G Protein-Coupled Receptors in Lung Adenocarcinoma: Evidence From Transcriptome Data and In Vitro Experiments. [PDF]

Clin Respir J
Yang F, Yang J, Yang G, Zhang Y.
europepmc   +1 more source

Biodiversity2Drugs—Renaissance of exploring nature‐derived peptides for GPCR ligand discovery

British Journal of Pharmacology, EarlyView.
Christian W. Gruber, Isabel Beets, Pierre‐Luc Boudreault, Vanderlan da S. Bolzani, Jens Carlsson, Pedro A. Fernandes, Michael Freissmuth, Nicolas Gilles, Ulf Göransson, Alexander S. Hauser, Christian Heinis, Jeroen Kool, William D. Lubell, Maria Vittoria Modica, Jana Selent, Jan Tytgat, Eivind A. B. Undheim, The Biodiversity2Drugs Consortium, Christian W. Gruber, Michael Freissmuth, Nicolas Gilles, Marion Chaigneau, Xavier Iturrioz, Pascal Kessler, Philippe Robin, Isabel Beets, Eivind A. B. Undheim, Jeroen Kool, Rob Leurs, Henry Vischer, Jan Tytgat, Steve Peigneur, Kathleen Carleer, Vanderlan da S. Bolzani, Ana Leticia Piros, William Lubell, Pierre‐Luc Boudreault, Alexander S. Hauser, Luuk R. Hoegen Dijkhof, Teemu K. E. Rönkkö, Maria Vittoria Modica, Serena Leone, Giovanna Ponte, Pedro Fernandes, Maria Joao Ramos, Jana Selent, Elizaveta Korchevaya, Tomasz Stepniewski, Jens Carlsson, Israel Cabeza de Vaca, Ulf Göransson, Sunithi Gunasekera, Erik Jacobsson, Christian Heinis, Tao Che, Maurice R. Elphick, Peter J. McCormick, Samuel Robinson, Helena Safavi‐Hemami, Roderich D. Süssmuth, Axel Touchard, Wilfred A. van der Donk, Denise Wootten   +62 more
wiley   +1 more source

Tumour Cell Size Control and Its Impact on Tumour Cell Function

Cell Proliferation, EarlyView.
The regulatory mechanism of the size of tumour cells and its impact on the functions of tumour cells, as well as a summary of potential therapeutic targets for the corresponding mechanisms. ABSTRACT Cell size is an important component of cell morphological characteristics.
Min Zhou, Mei Zhou, Yang Jin
wiley   +1 more source

GPCR signaling via cAMP nanodomains. [PDF]

Biochem J
Yadav R, Zaccolo M.
europepmc   +1 more source

Autoimmunity in MASLD: Focus on autoantibodies, anti‐apolipoprotein A1 IgG and G protein‐coupled receptors

European Journal of Clinical Investigation, EarlyView.
This review outlines the potential role of anti‐GPCR autoantibodies in MASLD/MASH, given their involvement in a wide range of diseases and their possible contribution to MASLD/MASH pathophysiology. We also focused on anti‐ApoA1 autoantibodies, sharing functional features with anti‐GPCR autoantibodies and have been shown to promote liver steatosis in ...
Sabrina Pagano, Emmanuel Somm, François R. Jornayvaz, Nicolas Vuilleumier   +3 more
wiley   +1 more source

Evaluation of Cellular Dielectric Spectroscopy, a Whole-Cell, Label-Free Technology for Drug Discovery on Gi-Coupled GPCRs

, 2007
Matthew F. Peters, Katharine S. Knappenberger, Deidre Wilkins, Linda A. Sygowski, Lois Ann Lazor, Jianwei Liu, Clay W. Scott   +6 more
openalex   +1 more source

Double GPCR trouble [PDF]

, 2008
Charlotte Harrison
openalex   +1 more source