Results 231 to 240 of about 92,178 (306)

Editorial: GPCRs: signal transduction

Frontiers in Molecular Biosciences
Nicole Perry-Hauser, Nicole Perry-Hauser, Stuart Maudsley, Yamina A. Berchiche, Lauren M. Slosky   +4 more
openaire   +4 more sources

Neuronal Activity Promotes Node‐Like Cluster Assembly Prior to Myelination and Remyelination in the Central Nervous System

Glia, Volume 74, Issue 4, April 2026.
Ronzano et al. show that neuronal activity promotes node‐like cluster (NLC) formation before (re)myelination by regulating β1Nav and Nav1.1, which are essential for NLC assembly. This may represent an intermediate step in activity‐driven myelination and contribute to the regulation of axonal conduction.
Rémi Ronzano, Clément Perrot, Elisa Mazuir, Melina Thetiot, Marie‐Stéphane Aigrot, Paul Stheneur, François‐Xavier Lejeune, Bruno Stankoff, Catherine Lubetzki, Nathalie Sol‐Foulon, Anne Desmazières   +10 more
wiley   +1 more source

Cytoplasmic tail diversity determines the effector bias of the adhesion GPCR ADGRL2. [PDF]

Cell Chem Biol
Garbett KA, Zheng C, Drube J, Hoffmann C, Gurevich VV, Sando RC.   +5 more
europepmc   +1 more source

Extracellular and Membrane Protein: Structure, Biological Functions, Diseases, and an Emerging Modality for Drug Discovery

MedComm, Volume 7, Issue 4, April 2026.
Targeted protein degradation represents a paradigm shift from traditional protein inhibition to complete protein elimination. This is achieved through three main strategies for degrading extracellular and membrane proteins: recruitment of cell‐surface LTRs, engagement of intracellular proteins, and receptor‐independent mechanisms.
Mengqing Zhao, Wenhao Yin, Jianjian Han, Huimin Wang, Zheng Liu, Lilong Liu, Wuxiang Mao   +6 more
wiley   +1 more source

Spatial patterning of contractility by a self-organized mechanogen activity gradient underlies Drosophila gastrulation. [PDF]

Nat Commun
Mundhe G, Dunsing-Eichenauer V, Philippe JM, Da Silva É, Collinet C, Lecuit T.   +5 more
europepmc   +1 more source

Human cells for human proteins: Isotope labeling in mammalian cells in suspension for functional NMR studies

Protein Science, Volume 35, Issue 4, April 2026.
Abstract In biological and biomedical research, the focus progressively moves towards difficult human proteins, which often can only be expressed in higher eukaryotic cells. Nuclear magnetic resonance (NMR) could contribute significantly to the understanding of important proteins as it is one of the most information‐rich methods.
Philip Rößler, Marco M. Ruckstuhl, Arnelle Löbbert, Timo Stühlinger, Lucia R. Franchini, Ching‐Ju Tsai, Roman Lichtenecker, Binesh Shrestha, Simon H. Rüdisser, Robert Konrat, Gebhard F. X. Schertler, Alvar D. Gossert   +11 more
wiley   +1 more source

Human class B1 GPCR modulation by plasma membrane lipids. [PDF]

Commun Biol
Chao KW, Wong L, Oqua AI, Kalayan J, Manchanda Y, Gebbie-Rayet J, Hedger G, Tomas A, Rouse SL.   +8 more
europepmc   +1 more source

StabLyzeGraph: High‐throughput screening of combinatorial mutations using graph neural networks

Protein Science, Volume 35, Issue 4, April 2026.
Abstract Engineering protein stability is a powerful strategy across biotechnology and medicine, supporting a broad range of applications such as atomic structure determination, discovery of therapeutic molecules, biomanufacturing, diagnostic reagents, industrial biocatalysis, etc.
Muhammad Waqas, Benito Natale, Michele Roggia, Prasenjit Prasad Saha, Mauro Mileni, Sandro Cosconati   +5 more
wiley   +1 more source

Prompt-based multimodal representation learning for drug repurposing. [PDF]

Brief Bioinform
Liu J, U K, Rana D, Meixuan Zhang S, Yu J, Yang S, Jin B, Wang X, Yang Z, Tang H, Zhao J.   +10 more
europepmc   +1 more source

Steroid Recognition in Adhesion GPCRs: A Structural and Pharmacological Perspective

Pharmacology Research &Perspectives, Volume 14, Issue 2, April 2026.
ABSTRACT Emerging evidence suggests steroids may act as generalizable ligands for adhesion GPCRs, a receptor class with considerable pharmacological potential. While most studies have focused on the ADGR‘G' subfamily, recent cryo‐EM structures of the androgens 5α‐dihydrotestosterone (5α‐DHT) and methenolone bound to ADGRD1 revealed a putative steroid ...
Bethany Fleming, Abdul‐Akim Guseinov, Irina G. Tikhonova, Graeme Milligan, Nicole A. Perry‐Hauser   +4 more
wiley   +1 more source