Results 21 to 30 of about 92,178 (306)
Molecular and Cellular Endocrinology, 2019 New technologies for spatial and temporal remote control of G protein-coupled receptors (GPCRs) are necessary to unravel the complexity of GPCR signalling in cells, tissues and living organisms. An effective approach, recently developed, consists on the design of light-operated ligands whereby light-dependent GPCR activity regulation can be achieved ...
Maria Ricart-Ortega +2 more
openaire +3 more sources
Specific and behaviorally consequential astrocyte Gq GPCR signaling attenuation in vivo with iβARK.
Neuron, 2021 Astrocytes respond to neurotransmitters and neuromodulators using G-protein-coupled receptors (GPCRs) to mediate physiological responses. Despite their importance, there has been no method to genetically, specifically, and effectively attenuate astrocyte
J. Nagai +11 more
semanticscholar +1 more source
Impact of GPCR Structures on Drug Discovery.
Cell, 2020 Structures of 70 unique G protein-coupled receptors (GPCRs) have been determined, with over 370 structures in total bound to different ligands and the receptors in various conformational states.
M. Congreve +3 more
semanticscholar +1 more source
Molecular Cloning and Expression of Human Regulators of G-Protein Signaling 4, 5, and 16
McGill Journal of Medicine, 2020 N ...
Aravind Athiviraham
doaj +1 more source
Platelets, 2021 Most agonists stimulate platelet Ca2+ rises via G-protein coupled receptors (GPCRs) or ITAM-linked receptors (ILRs). Well studied are the GPCRs stimulated by the soluble agonists thrombin (PAR1, PAR4), ADP (P2Y1, P2Y12), and thromboxane A2 (TP ...
Delia I. Fernández +2 more
doaj +1 more source
An Insight into GPCR and G-Proteins as Cancer Drivers
Cells, 2021 G-protein-coupled receptors (GPCRs) are the largest family of cell surface signaling receptors known to play a crucial role in various physiological functions, including tumor growth and metastasis.
P. Chaudhary, Soochong Kim
semanticscholar +1 more source
GPCR Signaling Regulation: The Role of GRKs and Arrestins
Frontiers in Pharmacology, 2019 Every animal species expresses hundreds of different G protein-coupled receptors (GPCRs) that respond to a wide variety of external stimuli. GPCRs-driven signaling pathways are involved in pretty much every physiological function and in many pathologies.
V. Gurevich, E. Gurevich
semanticscholar +1 more source
Angiotensin and biased analogs induce structurally distinct active conformations within a GPCR
Science, 2020 Choosing the drug to fit the protein Many approved drugs bind to G protein–coupled receptors (GPCRs). A challenge in targeting GPCRs is that different ligands preferentially activate different signaling pathways.
L. Wingler +9 more
semanticscholar +1 more source
A computational model for GPCR-ligand interaction prediction
Journal of Integrative Bioinformatics, 2020 G protein-coupled receptors (GPCRs) play an essential role in critical human activities, and they are considered targets for a wide range of drugs. Accordingly, based on these crucial roles, GPCRs are mainly considered and focused on pharmaceutical ...
Karimi Shiva +3 more
doaj +1 more source
GPCR homo-oligomerization [PDF]
Current Opinion in Cell Biology, 2019 G protein-coupled receptors (GPCRs) are an extensive class of trans-plasma membrane proteins that function to regulate a wide range of physiological functions. Despite a general perception that GPCRs exist as monomers an extensive literature has examined whether GPCRs can also form dimers and even higher-order oligomers, and if such organization ...
Milligan, Graeme +2 more
openaire +2 more sources