Results 21 to 30 of about 119,228 (259)

Nuclear localization of histamine receptor 2 in primary human lymphatic endothelial cells

Biology Open, 2022
Histamine exerts its physiological functions through its four receptor subtypes. In this work, we report the subcellular localization of histamine receptor 2 (H2R), a G protein-coupled receptor (GPCR), which is expressed in a wide variety of cell and ...
Sarit Pal, Anatoliy Gashev, Debarshi Roy
doaj   +1 more source

On the hierarchical classification of G Protein-Coupled Receptors [PDF]

, 2007
Motivation: G protein-coupled receptors (GPCRs) play an important role in many physiological systems by transducing an extracellular signal into an intracellular response. Over 50% of all marketed drugs are targeted towards a GPCR.
A. A. Freitas, A. Secker, Attwood, Bhasin, Bhasin, Bissantz, Cardoso, Christopoulos, D. R. Flower, Das, Davies, Flower, Flower, Foord, Gether, Gloriam, Guo, Horn, H  bert, J. Timmis, Karchin, Keerthi, Klabunde, Kolakowski, Lapinsh, M. Mendao, M. N. Davies, Milligan, Papasaikas, Prabhu, Sandberg, Schi  th   +31 more
core   +2 more sources

GPCR photopharmacology

Molecular and Cellular Endocrinology, 2019
New technologies for spatial and temporal remote control of G protein-coupled receptors (GPCRs) are necessary to unravel the complexity of GPCR signalling in cells, tissues and living organisms. An effective approach, recently developed, consists on the design of light-operated ligands whereby light-dependent GPCR activity regulation can be achieved ...
Maria Ricart-Ortega, Joan Font, Amadeu Llebaria   +2 more
openaire   +3 more sources

Molecular Cloning and Expression of Human Regulators of G-Protein Signaling 4, 5, and 16

McGill Journal of Medicine, 2020
N ...
Aravind Athiviraham
doaj   +1 more source

Platelet calcium signaling by G-protein coupled and ITAM-linked receptors regulating anoctamin-6 and procoagulant activity

Platelets, 2021
Most agonists stimulate platelet Ca2+ rises via G-protein coupled receptors (GPCRs) or ITAM-linked receptors (ILRs). Well studied are the GPCRs stimulated by the soluble agonists thrombin (PAR1, PAR4), ADP (P2Y1, P2Y12), and thromboxane A2 (TP ...
Delia I. Fernández, Marijke J. E. Kuijpers, Johan W. M. Heemskerk   +2 more
doaj   +1 more source

Structural and Functional Analysis of a β2-Adrenergic Receptor Complex with GRK5. [PDF]

, 2017
The phosphorylation of agonist-occupied G-protein-coupled receptors (GPCRs) by GPCR kinases (GRKs) functions to turn off G-protein signaling and turn on arrestin-mediated signaling.
Adams, Christopher M., Benovic, Jeffrey L., Betz, Robin M., Chung, Ka Young, Dror, Ron O., Du, Yang, Duc, Nguyen Minh, Kobilka, Brian K., Komolov, Konstantin E., Leib, Ryan D., Patra, Dhabaleswar, Rodrigues, João P.G.L.M., Skiniotis, Georgios   +12 more
core   +2 more sources

GPCR-OKB: the G protein coupled receptor oligomer knowledge base [PDF]

, 2010
Rapid expansion of available data about G Protein Coupled Receptor (GPCR) dimers/oligomers over the past few years requires an effective system to organize this information electronically.
Bouvier, M., Camacho-Artacho, M., Campagne, F., Devi, L.A., Dorff, K., Filizola, M., George, S.R., Javitch, J.A., Khelashvili, G., Lohse, M.J., Milligan, G., Neubig, R.R., Palczewski, K., Parmentier, M., Pin, J.-P., Shan, J., Skrabanek, L., Vriend, G., Vroling, B.   +18 more
core   +3 more sources

Prediction and classification for GPCR sequences based on ligand specific features [PDF]

, 2006
Functional identification of G-Protein Coupled Receptors (GPCRs) is one of the current focus areas of pharmaceutical research. Although thousands of GPCR sequences are known, many of them are orphan sequences (the activating ligand is unknown). Therefore,
F. Horn, G.E. Tusnády, K.R. Sreekumar, M. Bouvier, R. Karchin, S. Altshul, T. Gudermann, W. Pearson, Y. Huang   +8 more
core   +1 more source

A computational model for GPCR-ligand interaction prediction

Journal of Integrative Bioinformatics, 2020
G protein-coupled receptors (GPCRs) play an essential role in critical human activities, and they are considered targets for a wide range of drugs. Accordingly, based on these crucial roles, GPCRs are mainly considered and focused on pharmaceutical ...
Karimi Shiva, Ahmadi Maryam, Goudarzi Farjam, Ferdousi Reza   +3 more
doaj   +1 more source

GPCR homo-oligomerization [PDF]

Current Opinion in Cell Biology, 2019
G protein-coupled receptors (GPCRs) are an extensive class of trans-plasma membrane proteins that function to regulate a wide range of physiological functions. Despite a general perception that GPCRs exist as monomers an extensive literature has examined whether GPCRs can also form dimers and even higher-order oligomers, and if such organization ...
Milligan, Graeme, Ward, Richard J., Marsango, Sara   +2 more
openaire   +2 more sources