Results 21 to 30 of about 92,511 (354)
An Insight into GPCR and G-Proteins as Cancer Drivers
Cells, 2021 G-protein-coupled receptors (GPCRs) are the largest family of cell surface signaling receptors known to play a crucial role in various physiological functions, including tumor growth and metastasis.
P. Chaudhary, Soochong Kim
semanticscholar +1 more source
Molecular Cloning and Expression of Human Regulators of G-Protein Signaling 4, 5, and 16
McGill Journal of Medicine, 2020 N ...
Aravind Athiviraham
doaj +1 more source
Platelets, 2021 Most agonists stimulate platelet Ca2+ rises via G-protein coupled receptors (GPCRs) or ITAM-linked receptors (ILRs). Well studied are the GPCRs stimulated by the soluble agonists thrombin (PAR1, PAR4), ADP (P2Y1, P2Y12), and thromboxane A2 (TP ...
Delia I. Fernández +2 more
doaj +1 more source
Angiotensin and biased analogs induce structurally distinct active conformations within a GPCR
Science, 2020 Choosing the drug to fit the protein Many approved drugs bind to G protein–coupled receptors (GPCRs). A challenge in targeting GPCRs is that different ligands preferentially activate different signaling pathways.
L. Wingler +9 more
semanticscholar +1 more source
Molecular and Cellular Endocrinology, 2019 New technologies for spatial and temporal remote control of G protein-coupled receptors (GPCRs) are necessary to unravel the complexity of GPCR signalling in cells, tissues and living organisms. An effective approach, recently developed, consists on the design of light-operated ligands whereby light-dependent GPCR activity regulation can be achieved ...
Maria Ricart-Ortega +2 more
openaire +3 more sources
A computational model for GPCR-ligand interaction prediction
Journal of Integrative Bioinformatics, 2020 G protein-coupled receptors (GPCRs) play an essential role in critical human activities, and they are considered targets for a wide range of drugs. Accordingly, based on these crucial roles, GPCRs are mainly considered and focused on pharmaceutical ...
Karimi Shiva +3 more
doaj +1 more source
GPCR Signaling Regulation: The Role of GRKs and Arrestins
Frontiers in Pharmacology, 2019 Every animal species expresses hundreds of different G protein-coupled receptors (GPCRs) that respond to a wide variety of external stimuli. GPCRs-driven signaling pathways are involved in pretty much every physiological function and in many pathologies.
V. Gurevich, E. Gurevich
semanticscholar +1 more source
Receptor-Arrestin Interactions: The GPCR Perspective
Biomolecules, 2021 Arrestins are a small family of four proteins in most vertebrates that bind hundreds of different G protein-coupled receptors (GPCRs). Arrestin binding to a GPCR has at least three functions: precluding further receptor coupling to G proteins ...
M. Seyedabadi +3 more
semanticscholar +1 more source
A Web Server for GPCR-GPCR Interaction Pair Prediction
Frontiers in Endocrinology, 2022 The GGIP web server (https://protein.b.dendai.ac.jp/GGIP/) provides a web application for GPCR-GPCR interaction pair prediction by a support vector machine. The server accepts two sequences in the FASTA format. It responds with a prediction that the input GPCR sequence pair either interacts or not.
Wataru Nemoto +7 more
openaire +3 more sources
CHIMIA, 2021 Numerous members of the human G protein-coupled receptor (GPCR) superfamily are receptors of therapeutic interest. GPCRs are considered to be highly tractable for drug discovery, representing the targets of approximately one-third of currently licensed ...
Kalyan Bharati Akondi +2 more
doaj +1 more source