Results 21 to 30 of about 142,523 (351)

The G protein-coupled receptor heterodimer network (GPCR-HetNet) and its hub components [PDF]

, 2014
G protein-coupled receptors (GPCRs) oligomerization has emerged as a vital characteristic of receptor structure. Substantial experimental evidence supports the existence of GPCR-GPCR interactions in a coordinated and cooperative manner.
Agnati, Luigi F, Borroto-Escuela, Dasiel O, Brito, Ismel, Di Palma, Michael, Duchou, Jolien, Fuxe, Kjell, Guidolin, Diego, Oflijan, Julia, Rivera, Alicia, Romero-Fernandez, Wilber, Skieterska, Kamila, Suárez-Boomgaard, Diana, Van Craenenbroeck, Kathleen   +12 more
core   +4 more sources

Angiotensin and biased analogs induce structurally distinct active conformations within a GPCR

Science, 2020
Choosing the drug to fit the protein Many approved drugs bind to G protein–coupled receptors (GPCRs). A challenge in targeting GPCRs is that different ligands preferentially activate different signaling pathways.
L. Wingler, M. Skiba, Conor McMahon, D. Staus, Alissa L. W. Kleinhenz, Carl-Mikael Suomivuori, Naomi R. Latorraca, R. Dror, R. Lefkowitz, A. Kruse   +9 more
semanticscholar   +1 more source

Molecular Cloning and Expression of Human Regulators of G-Protein Signaling 4, 5, and 16

McGill Journal of Medicine, 2020
N ...
Aravind Athiviraham
doaj   +1 more source

Platelet calcium signaling by G-protein coupled and ITAM-linked receptors regulating anoctamin-6 and procoagulant activity

Platelets, 2021
Most agonists stimulate platelet Ca2+ rises via G-protein coupled receptors (GPCRs) or ITAM-linked receptors (ILRs). Well studied are the GPCRs stimulated by the soluble agonists thrombin (PAR1, PAR4), ADP (P2Y1, P2Y12), and thromboxane A2 (TP ...
Delia I. Fernández, Marijke J. E. Kuijpers, Johan W. M. Heemskerk   +2 more
doaj   +1 more source

GPCR-OKB: the G protein coupled receptor oligomer knowledge base [PDF]

, 2010
Rapid expansion of available data about G Protein Coupled Receptor (GPCR) dimers/oligomers over the past few years requires an effective system to organize this information electronically.
Bouvier, M., Camacho-Artacho, M., Campagne, F., Devi, L.A., Dorff, K., Filizola, M., George, S.R., Javitch, J.A., Khelashvili, G., Lohse, M.J., Milligan, G., Neubig, R.R., Palczewski, K., Parmentier, M., Pin, J.-P., Shan, J., Skrabanek, L., Vriend, G., Vroling, B.   +18 more
core   +3 more sources

Receptor-Arrestin Interactions: The GPCR Perspective

Biomolecules, 2021
Arrestins are a small family of four proteins in most vertebrates that bind hundreds of different G protein-coupled receptors (GPCRs). Arrestin binding to a GPCR has at least three functions: precluding further receptor coupling to G proteins ...
M. Seyedabadi, Mehdi Gharghabi, E. Gurevich, V. Gurevich   +3 more
semanticscholar   +1 more source

Structural and Functional Analysis of a β2-Adrenergic Receptor Complex with GRK5. [PDF]

, 2017
The phosphorylation of agonist-occupied G-protein-coupled receptors (GPCRs) by GPCR kinases (GRKs) functions to turn off G-protein signaling and turn on arrestin-mediated signaling.
Adams, Christopher M., Benovic, Jeffrey L., Betz, Robin M., Chung, Ka Young, Dror, Ron O., Du, Yang, Duc, Nguyen Minh, Kobilka, Brian K., Komolov, Konstantin E., Leib, Ryan D., Patra, Dhabaleswar, Rodrigues, João P.G.L.M., Skiniotis, Georgios   +12 more
core   +2 more sources

Structure and functional motifs of GCR1, the only plant protein with a GPCR fold? [PDF]

, 2013
Whether GPCRs exist in plants is a fundamental biological question. Interest in deorphanizing new G protein coupled receptors (GPCRs), arises because of their importance in signaling.
Abdalla, Nuradin Y, Bailey, Gregory R, Jordon, Sian R D, Reeves, Philip J, Reynolds, Christopher A, Taddese, Bruck, Upton, Graham J G   +6 more
core   +1 more source

GPCR Signaling Regulation: The Role of GRKs and Arrestins

Frontiers in Pharmacology, 2019
Every animal species expresses hundreds of different G protein-coupled receptors (GPCRs) that respond to a wide variety of external stimuli. GPCRs-driven signaling pathways are involved in pretty much every physiological function and in many pathologies.
V. Gurevich, E. Gurevich
semanticscholar   +1 more source

A computational model for GPCR-ligand interaction prediction

Journal of Integrative Bioinformatics, 2020
G protein-coupled receptors (GPCRs) play an essential role in critical human activities, and they are considered targets for a wide range of drugs. Accordingly, based on these crucial roles, GPCRs are mainly considered and focused on pharmaceutical ...
Karimi Shiva, Ahmadi Maryam, Goudarzi Farjam, Ferdousi Reza   +3 more
doaj   +1 more source