Results 1 to 10 of about 67,843 (252)
The Secretin GPCRs Descended from the Family of Adhesion GPCRs [PDF]
Molecular Biology and Evolution, 2008 The Adhesion G-protein-coupled receptors (GPCRs) are the most complex gene family among GPCRs with large genomic size, multiple introns, and a fascinating flora of functional domains, though the evolutionary origin of this family has been obscure. Here we studied the evolution of all class B (7tm2)-related genes, including the Adhesion, Secretin, and ...
Karl J V, Nordström +4 more
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An Alternative Mode of GPCR Transactivation: Activation of GPCRs by Adhesion GPCRs
International Journal of Molecular SciencesG protein-coupled receptors (GPCRs), critical for cellular communication and signaling, represent the largest cell surface protein family and play important roles in numerous pathophysiological processes. Consequently, GPCRs have become a primary focus in drug discovery efforts. Beyond their traditional G protein-dependent signaling pathways, GPCRs are
Hsi-Hsien Lin
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Acta Pharmacologica Sinica, 2012 G-protein-coupled receptors (GPCRs), which represent the largest gene family in the human genome, play a crucial role in multiple physiological functions as well as in tumor growth and metastasis. For instance, various molecules like hormones, lipids, peptides and neurotransmitters exert their biological effects by binding to these seven-transmembrane ...
Lappano R, MAGGIOLINI, Marcello
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, 2011 In this chapter, we describe a method for detecting the ubiquitination status of G protein-coupled receptors (GPCRs). This involves co-expression of a GPCR with an epitope-tagged ubiquitin construct in a -heterologous mammalian expression system. Stimulus-dependent modification of the GPCR by -ubiquitin is detected by immunoprecipitation and subsequent
Adriana, Caballero, Adriano, Marchese
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Molecular and Cellular Endocrinology, 2019 New technologies for spatial and temporal remote control of G protein-coupled receptors (GPCRs) are necessary to unravel the complexity of GPCR signalling in cells, tissues and living organisms. An effective approach, recently developed, consists on the design of light-operated ligands whereby light-dependent GPCR activity regulation can be achieved ...
Maria Ricart-Ortega +2 more
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A Web Server for GPCR-GPCR Interaction Pair Prediction
Frontiers in Endocrinology, 2022 The GGIP web server (https://protein.b.dendai.ac.jp/GGIP/) provides a web application for GPCR-GPCR interaction pair prediction by a support vector machine. The server accepts two sequences in the FASTA format. It responds with a prediction that the input GPCR sequence pair either interacts or not.
Wataru Nemoto +7 more
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PRED-GPCR: GPCR recognition and family classification server [PDF]
Nucleic Acids Research, 2004 The vast cell-surface receptor family of G-protein coupled receptors (GPCRs) is the focus of both academic and pharmaceutical research due to their key role in cell physiology along with their amenability to drug intervention. As the data flow rate from the various genome and proteome projects continues to grow, so does the need for fast, automated and
Panagiotis K. Papasaikas +4 more
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Pharmacology of Antagonism of GPCR
Biological and Pharmaceutical Bulletin, 2022 Agonists are defined as the ligands that activate intracellular signaling and evoke cellular responses. Synthetic and endogenous agonists should bind specific amino acids to activate G protein-coupled receptor (GPCR). Agonists that induce maximal responses are full agonists. Partial agonists cannot induce full responses unlike full agonists.
Kurose, Hitoshi, Kim, Sang Geon
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Neuropeptide GPCRs in Neuroendocrinology [PDF]
Frontiers in Endocrinology, 2014 The human genome encompasses ~ 860 G protein-coupled receptors (GPCRs) including 374 non-chemosensory GPCRs. Half of these latter GPCRs recognize (neuro)peptides as natural ligands. GPCRs thus play a pivotal role in neuroendocrine communication. In particular, GPCRs are involved in the neuroendocrine control of feeding behavior, reproduction, growth ...
Vaudry, Hubert, Seong, Jae Young
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