Results 1 to 10 of about 41,836 (158)
Cells, 2021 G-protein-coupled receptors (GPCRs) play an integral role in the neurobiology of psychiatric disorders. Almost all neurotransmitters involved in psychiatric disorders act through GPCRs, and GPCRs are the most common targets of therapeutic drugs currently
Wedad Alhassen +2 more
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Russian Open Medical Journal, 2023 Publication interest in cannabinoids, including phytocannabinoids, endogenous cannabinoids, synthetic cannabinoids and cannabinomimetic compounds, is due to the therapeutic potential of these compounds in inflammatory pathology.
Oksana Yu. Kytikova +3 more
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Journal of Integrative Neuroscience, 2023 Background: Cholecystokinin (CCK) is one of the most abundant peptides in the central nervous system and is believed to function as a neurotransmitter as well as a gut hormone with an inverse correlation of its level to anxiety and depression. Therefore,
Pradeep Paudel +5 more
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CHIMIA, 2021 Heteronuclear NMR in combination with isotope labelling is used to study folding of polypeptides induced by metals in the case of metallothioneins, binding of the peptidic allosteric modulator ρ-TIA to the human G-protein coupled α1b adrenergic receptor,
Oliver Zerbe +5 more
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Pharmaceuticals, 2021 G-protein-coupled receptors (GPCRs) comprise a large protein superfamily divided into six classes, rhodopsin-like (A), secretin receptor family (B), metabotropic glutamate (C), fungal mating pheromone receptors (D), cyclic AMP receptors (E) and frizzled (
Salomé Gonçalves-Monteiro +5 more
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Acta Pharmacologica Sinica, 2012 G-protein-coupled receptors (GPCRs), which represent the largest gene family in the human genome, play a crucial role in multiple physiological functions as well as in tumor growth and metastasis. For instance, various molecules like hormones, lipids, peptides and neurotransmitters exert their biological effects by binding to these seven-transmembrane ...
Lappano R, MAGGIOLINI, Marcello
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Cells, 2023 G protein-coupled receptors (GPCRs) are expressed essentially on all cells, facilitating cellular responses to external stimuli, and are involved in nearly every biological process.
Saeed Al Mahri +10 more
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The structural study of mutation-induced inactivation of human muscarinic receptor M4
IUCrJ, 2020 Human muscarinic receptor M4 belongs to the class A subfamily of the G-protein-coupled receptors (GPCRs). M4 has emerged as an attractive drug target for the treatment of Alzheimer's disease and schizophrenia.
Jingjing Wang +11 more
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The orphan receptor GPR88 blunts the signaling of opioid receptors and multiple striatal GPCRs
eLife, 2020 GPR88 is an orphan G protein-coupled receptor (GPCR) considered as a promising therapeutic target for neuropsychiatric disorders; its pharmacology, however, remains scarcely understood.
Thibaut Laboute +12 more
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Recent advances on the role of G-protein-coupled receptors in kidney diseases
生物医学转化, 2022 The G-protein-coupled receptors (GPCRs) are widely expressed in many cell types and participate in various cellular biological processes. Several studies have shown that GPCRs-mediated signaling pathways play significant roles in maintaining renal ...
Wang Xiaojie +5 more
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