Results 11 to 20 of about 67,843 (252)

The Origins of GPCRs. [PDF]

Int J Mol Sci
G protein-coupled receptors (GPCRs) are present in all kingdoms of life. GPCRs are the largest family of signaling proteins in animals, including humans.
Gurevich VV.
europepmc   +2 more sources

Uncovering G Protein-Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis. [PDF]

Ann Clin Transl Neurol
ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Yang J, Zhang D, Liu D, Lin D, Wang H.
europepmc   +2 more sources

Adhesion GPCRs are widely expressed throughout the subsections of the gastrointestinal tract [PDF]

, 2012
Background: G protein-coupled receptors (GPCRs) represent one of the largest families of transmembrane receptors and the most common drug target. The Adhesion subfamily is the second largest one of GPCRs and its several members are known to mediate ...
Schiöth, Helgi B,, Olszewski, Pawel K, Cedernaes, Jonathan,, Vergoni, Anna V, Schiöth, Helgi B, Jonathan Cedernaes, Schiöth, Helgi B., Anna V Vergoni, Pawel K Olszewski, Badiali, Luca, Luca Badiali, Olof Nylander, Badiali, Luca,, Helgi B Schiöth, Nylander, Olof, Nylander, Olof,, VERGONI, Anna Valeria, Olszewski, Pawel K., Vergoni, Anna V., Cedernaes, Jonathan, Olszewski, Pawel K,   +20 more
core   +2 more sources

Neuropeptide GPCRs in C. elegans. [PDF]

, 2012
Like most organisms, the nematode Caenorhabditis elegans relies heavily on neuropeptidergic signaling. This tiny animal represents a suitable model system to study neuropeptidergic signaling networks with single cell resolution due to the availability of
Schoofs, Liliane, Van Rompay, Liesbeth, Janssen, Tom, Frooninckx, Lotte, Temmerman, Liesbet, Husson, Steven J., Van Sinay, Elien, Beets, Isabel   +7 more
core   +2 more sources

A Robust and Rapid Method of Producing Soluble, Stable, and Functional G-Protein Coupled Receptors [PDF]

, 2011
Membrane proteins, particularly G-protein coupled receptors (GPCRs), are notoriously difficult to express. Using commercial E.coli cell-free systems with the detergent Brij-35, we could rapidly produce milligram quantities of 13 unique GPCRs ...
Braun, Dieter, Shuguang Zhang, Baaske Philipp, Moran Jerabek-Willemsen, Geissler, Sandra, Duhr, Stefan, Duhr Stefan, Corin, Karolina A., Sandra Geissler, Wienken Christoph J., Christoph J. Wienken, Geissler Sandra, Jerabek-Willemsen, Moran, Christoph J Wienken, Zhang Shuguang, Stefan Duhr, Emily Brown, Wang Xiaoqiang, Philipp Baaske, Deepali B. Ravel, Brown, Emily, Song Junyao, Xiaoqiang Wang, Braun Dieter, Karolina Corin, Junyao Song, Wang, Xiaoqiang, Dieter Braun, Baaske, Philipp, Wienken, Christoph J., Ravel Deepali B., Corin, Karolina, Ravel, Deepali B., Brown Emily, Song, Junyao, Jerabek-Willemsen Moran, Corin Karolina, Zhang, Shuguang, Deepali B Ravel, Brown, Emily E., Ra Geissler   +40 more
core   +1 more source

Phylogenomic analysis reveals extensive phylogenetic mosaicism in the Human GPCR Superfamily [PDF]

, 2007
A novel high throughput phylogenomic analysis (HTP) was applied to the rhodopsin G-protein coupled receptor (GPCR) family. Instances of phylogenetic mosaicism between receptors were found to be frequent, often as instances of correlated mosaicism and ...
Allaby, Robin G., Woodwark, Mathew, Robin G. Allaby, Mathew Woodwark   +3 more
core   +1 more source

β-arrestins and endocrine-related GPCRs

, 2021
International audienceG protein-coupled receptors (GPCRs) allow target cells to respond to a wide array of hormones. Mounting evidences point to GPCRs being functionally coupled to multiple transduction mechanisms, some of them not involving ...
Yvinec, Romain, Crépieux, Pascale, Poupon, Anne, de Pascali, Francesco, Bozon, Véronique, Jean-Alphonse, Frédéric, Pellissier, Lucie P., Anne Poupon, Bruneau, Gilles, Frédéric Jean-Alphonse, Francesco De Pascali, Gilles Bruneau, Lucie P. Pellissier, Pauline Raynaud, Romain Yvinec, Eric Reiter, Tahir, Shifa, Shifa Tahir, Véronique Bozon, Pascale Crépieux, Raynaud, Pauline, Reiter, Eric   +21 more
core   +1 more source

The role of dimerisation in the cellular trafficking of G-protein-coupled receptors [PDF]

, 2010
The concept that G-protein-coupled receptors can exist as homomeric and/or heteromeric complexes is now well established. Despite this, how dynamic such interactions are and if this may be modulated during receptor trafficking remain topics of debate ...
Milligan, Graeme
core   +1 more source

Allosteric modulators targeting GPCRs

, 2020
The remarkable precision of the pharmacological modulation, including high degree of specificity, probe dependence, and signaling bias, confers to GPCR allosteric modulators unique advantages over orthosteric classical ligands.
María L. López-Rodríguez, Bellinda Benhamú, López Rodríguez, María Luz, Henar Vázquez-Villa, Benhamú Salama, Bellinda, Vázquez Villa, María Del Henar   +5 more
core   +1 more source

GPCRTree: online hierarchical classification of GPCR function [PDF]

, 2008
Background: G protein-coupled receptors (GPCRs) play important physiological roles transducing extracellular signals into intracellular responses. Approximately 50% of all marketed drugs target a GPCR.
Davies Matthew N, Clark, Edward, Halling-Brown Mark, Flower Darren R, Moss, David S., Alex A Freitas, Halling-Brown, Mark D., Clark, E., Timmis Jon, Flower, Darren R, Andrew Secker, Freitas, Alex A., Timmis, J., Davies, M.N., David S Moss, Secker, Andrew D., Secker, A., Halling-Brown, Mark, Moss David S, Timmis, Jon, Freitas, A.A., Mark Halling-Brown, Clark Edward, Secker Andrew, Secker, Andrew, Flower, Darren R., Jon Timmis, Edward Clark, Matthew N Davies, Freitas Alex A, Davies, Matthew N., Darren R Flower, Flower, D.R.   +32 more
core   +1 more source