G protein-coupled receptors not currently in the spotlight: free fatty acid receptor 2 and GPR35 [PDF]
, 2017 It is widely appreciated that G protein-coupled receptors have been the most successfully exploited class of targets for the development of small molecule medicines. Despite this, to date, less than 15% of the non-olfactory G protein-coupled receptors in
Milligan, Graeme
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Genetically Encoded Photo-cross-linkers Map the Binding Site of an Allosteric Drug on a G Protein-Coupled Receptor [PDF]
, 2012 G protein-coupled receptors (GPCRs) are dynamic membrane proteins that bind extracellular molecules to transduce signals. Although GPCRs represent the largest class of therapeutic targets, only a small percentage of their ligand-binding sites are ...
Abrol, Ravinder +5 more
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A Web Server for GPCR-GPCR Interaction Pair Prediction
Frontiers in Endocrinology, 2022 The GGIP web server ( https://protein.b.dendai.ac.jp/GGIP/ ) provides a web application for GPCR-GPCR interaction pair prediction by a support vector machine. The server accepts two sequences in the FASTA format. It responds with a prediction that the input GPCR sequence pair either interacts
Wataru Nemoto +7 more
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An Olfactory Receptor Pseudogene whose Function emerged in Humans [PDF]
, 2007 Human olfactory receptor, hOR17-210, is identified as a pseudogene in the human genome. Experimental data has shown however, that the gene product of cloned hOR17-210 cDNA was able to bind an odorant-binding protein and is narrowly tuned for excitation ...
Catherine Ronin +6 more
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Rules and mechanisms governing G protein coupling selectivity of GPCRs
Cell Reports, 2023 Summary: G protein-coupled receptors (GPCRs) convert extracellular stimuli into intracellular signaling by coupling to heterotrimeric G proteins of four classes: Gi/o, Gq, Gs, and G12/13.
Ikuo Masuho +8 more
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Insertion of T4-lysozyme (T4L) can be a useful tool for studying olfactory-related GPCRs. [PDF]
, 2012 The detergents used to solubilize GPCRs can make crystal growth the rate-limiting step in determining their structure. The Kobilka laboratory showed that insertion of T4-lysozyme (T4L) in the 3rd intracellular loop is a promising strategy towards ...
Baaske +43 more
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Frontiers in Endocrinology, 2021 The prevalence of non-alcoholic fatty liver disease (NAFLD) is globally increasing. Gaining control over disease-related events in non-alcoholic steatohepatitis (NASH), an advanced form of NAFLD, is currently an unmet medical need.
Takefumi Kimura +4 more
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Nezara viridula (Hemiptera: Pentatomidae) transcriptomic analysis and neuropeptidomics [PDF]
, 2018 Stinkbugs (Hemiptera: Pentatomidae) are of major economic importance as pest of crops. Among the species composing the stinkbug complex, Nezara viridula is one of the most abundant in Brazil, Argentina and the Southern USA. However, this species has been
Catalano, María Inés +6 more
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G Protein-Coupled Receptors in Osteoarthritis: A Novel Perspective on Pathogenesis and Treatment
Frontiers in Cell and Developmental Biology, 2021 G protein-coupled receptors (GPCRs) are transmembrane receptor proteins that trigger numerous intracellular signaling pathways in response to the extracellular stimuli.
Ze-qin Wen +9 more
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Unique pharmacological properties of serotoninergic G-protein coupled receptors from cestodes. [PDF]
PLoS Neglected Tropical Diseases, 2018 BACKGROUND:Cestodes are a diverse group of parasites, some of them being agents of neglected diseases. In cestodes, little is known about the functional properties of G protein coupled receptors (GPCRs) which have proved to be highly druggable targets in
Federico Camicia +13 more
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