Results 101 to 110 of about 10,884 (213)

Application of Hierarchical Matrix Techniques To The Homogenization of Composite Materials [PDF]

, 2013
In this paper, we study numerical homogenization methods based on integral equations. Our work is motivated by materials such as concrete, modeled as composites structured as randomly distributed inclusions imbedded in a matrix.
Cazeaux, Paul, Zahm, Olivier
core   +2 more sources

Targeting ROCK1/YAP1 Axis Ameliorates Inflammation‐Induced Prostatic Hyperplasia via Stabilising SIRT1‐Dependent Mitochondrial Dynamics

Cell Proliferation, Volume 59, Issue 2, February 2026.
Prostate‐specific YAP1 overexpression induces pathological BPH phenogenesis. Targeting ROCK1/YAP1 with fasudil and verteporfin alleviates inflammatory BPH lesions. YAP1 orchestrates mitochondrial dysfunction and oxidative stress via suppressing SIRT1 function.
Dongxu Lin, Pengyu Wei, Mengyang Zhang, Kang Li, Lina Li, Zhipeng Li, Changcheng Luo, Wenbo Kuang, Kai Cui, Zhong Chen   +9 more
wiley   +1 more source

Interplay of anisotropy in shape and interactions in charged platelet suspensions

, 2014
Motivated by the intriguing phase behavior of charged colloidal platelets, we investigate the structure and dynamics of charged repulsive disks by means of Monte-Carlo simulations.
Allen M. P., Emmanuel Trizac, Frenkel D., Jean-Jacques Weis, Patrick Davidson, Pierre Levitz, Sara Jabbari-Farouji   +6 more
core   +3 more sources

Emerging roles for the novel estrogen-sensing receptor GPER1 in the CNS [PDF]

, 2017
Estrogens play a key role in regulating reproductive and neuroendocrine function by activating classical nuclear steroid receptors that act as ligand gated transcription factors.
Abdelhamid, Adams, Akama, Al-Sweidi, Almey, Almey, Almey, Amy Alexander, Andrew J. Irving, Ariazi, Bliss, Bologa, Bourque, Brailoiu, Brinton, Briz, Briz, Chen, Choleris, Collingridge, Daniel, Davis, Dennis, Ding, Dubal, Ervin, Evans, Filardo, Filardo, Filardo, Foy, Frick, Frick, Fukazawa, Fukuda, Funakoshi, Gabor, Geary, Gibbs, Gibbs, Gillies, Gingerich, Gould, Gros, Gruber, Hall, Hammond, Hammond, Hammond, Hawley, Hazell, Isensee, Jenni Harvey, Kang, Kastenberger, Kastenberger, Kelly, Kramár, Kretz, Kwon, Lagrange, Langer, Lebesgue, Levin, Liu, Liu, Liu, Magalhaes, Maggiolini, Man, Marin, McEwen, McEwen, Micevych, Milner, Milner, Mitterling, Moga, Mukai, Murakami, Mårtensson, Nilsson, Noel, Otto, Park, Petrie, Potier, Prossnitz, Prossnitz, Prossnitz, Qiu, Revankar, Romeo, Rudolf, Ruiz-Palmero, Ruiz-Palmero, Sanchez, Sellers, Simpkins, Simpkins, Smejkalova, Smith, Smith, Smith, Sortino, Srivastava, Srivastava, Srivastava, Srivastava, Sudo, Sun, Tada, Thomas, Thomas, Thomas, Tsai, Vasudevan, Walf, Walf, Wang, Waters, Woolley, Woolley, Zadran, Zhang, Zhang, Zhou, Zhou, Zhou   +128 more
core   +2 more sources

17‐β‐Estradiol Protects Chondrocytes From Senescence and Ameliorates Osteoarthritis Progression via ERα‐AKT‐FOXO4 Pathway

Journal of Cellular and Molecular Medicine, Volume 30, Issue 3, February 2026.
ABSTRACT Osteoarthritis (OA) is a prevalent cause of joint pain in elderly individuals, and chondrocyte senescence plays a crucial role in its pathogenesis. FOXO4 has been identified as a crucial molecule in cellular senescence. However, little is known regarding its role in OA and the regulation of its expression.
Yikai Liu, Jiangshan Ai, Zian Zhang, Xinzhe Lu, Chaoqun Yu, Yejun Zha, Haining Zhang   +6 more
wiley   +1 more source

Acute Stress Attenuates Hepatic Ischemia–Reperfusion Injury via Hypothalamic CRH Neuron‐Induced HPA Axis Activation

CNS Neuroscience &Therapeutics, Volume 32, Issue 1, January 2026.
This study demonstrates the protective effect of acute restraint stress (ARS) against hepatic ischemia–reperfusion injury (HIRI) in mice and investigates its specific neuroendocrine mechanisms. During ARS, excitability of PVNCRH neurons significantly increases, which drives HPA axis to release corticosterone, thereby reducing hepatic inflammation and ...
Xiaoqi Lin, Dan Yang, Shuyang Wang, Baoshan Wang, Ling Zhu, Yanyu Zhou, Yifei Zhou, Song Zhang, Qionghui Zhan, Yingfu Jiao, Weifeng Yu, Liqun Yang, Po Gao   +12 more
wiley   +1 more source

ERα-targeted endocrine therapy, resistance and the role of GPER

Steroids, 2019
Endocrine therapy is an effective option for the treatment of estrogen receptor alpha (ERα)-positive breast cancers. Unfortunately, a large fraction of women relapse with endocrine-resistant tumors. The presence of constitutively active ERα mutants, found in a subset of relapse tumors, is thought to be an important endocrine resistance mechanism and ...
Richard A. Pepermans, Eric R. Prossnitz
openaire   +3 more sources

G protein-coupled estrogen receptor expression in postnatal developing mouse retina

Frontiers in Ophthalmology
IntroductionEstrogen has emerged as a multifaceted signaling molecule in the retina, playing an important role in neural development and providing neuroprotection in adults.
Wendy L. Piñon-Teal, Judith Mosinger Ogilvie, Judith Mosinger Ogilvie   +2 more
doaj   +1 more source

A calixpyrrole derivative acts as an antagonist to GPER, a G-protein coupled receptor: mechanisms and models

Disease Models & Mechanisms, 2015
Estrogens regulate numerous pathophysiological processes, mainly by binding to and activating estrogen receptor (ER)α and ERβ. Increasing amounts of evidence have recently demonstrated that G-protein coupled receptor 30 (GPR30; also known as GPER) is ...
Rosamaria Lappano, Camillo Rosano, Assunta Pisano, Maria Francesca Santolla, Ernestina Marianna De Francesco, Paola De Marco, Vincenza Dolce, Marco Ponassi, Lamberto Felli, Grazia Cafeo, Franz Heinrich Kohnke, Sergio Abonante, Marcello Maggiolini   +12 more
doaj   +1 more source

Intramuscular sex steroid hormones are associated with skeletal muscle strength and power in women with different hormonal status [PDF]

, 2015
Peer ...
Butler-Browne, Gillian, Horttanainen, Mia, Kangas, Reeta, Kaprio, Jaakko, Kovanen, Vuokko, Mouly, Vincent, Niskala, Paula, Pollanen, Eija, Sipila, Sarianna   +8 more
core   +3 more sources