O-mannosylation of misfolded ER proteins promotes ERAD [PDF]
The EMBO JournalProtein quality control (PQC) in the secretory pathway, a process critically linked to numerous human diseases, begins in the endoplasmic reticulum (ER) and involves ER-associated degradation (ERAD) of terminally misfolded proteins.
Leticia Lemus +4 more
doaj +2 more sources
The GPI-Anchored Aspartyl Proteases Encoded by the YPS1 and YPS7 Genes of Candidozyma auris and Their Role Under Stress Conditions [PDF]
Journal of FungiCandidozyma auris is a multidrug-resistant, thermo- and osmotolerant yeast capable of persisting on biotic and abiotic surfaces, attributes likely linked to its cell wall composition.
Alvaro Vidal-Montiel +7 more
doaj +2 more sources
A hypomorphic PIGA gene mutation causes severe defects in neuron development and susceptibility to complement-mediated toxicity in a human iPSC model. [PDF]
PLoS ONE, 2017 Mutations in genes involved in glycosylphosphatidylinositol (GPI) anchor biosynthesis underlie a group of congenital syndromes characterized by severe neurodevelopmental defects.
Xuan Yuan +10 more
doaj +1 more source
Glycosylphosphatidylinositol-Anchor Synthesis in Plants: A Glycobiology Perspective
Frontiers in Plant Science, 2020 More than 200 diverse secretory proteins from Arabidopsis thaliana carry a glycosylphosphatidylinositol (GPI) lipid anchor covalently attached to their carboxyl-terminus.
Gernot Beihammer +3 more
doaj +1 more source
N-glycans and glycosylphosphatidylinositol-anchor act on polarized sorting of mouse PrP(C) in Madin-Darby canine kidney cells. [PDF]
PLoS ONE, 2011 The cellular prion protein (PrP(C)) plays a fundamental role in prion disease. PrP(C) is a glycosylphosphatidylinositol (GPI)-anchored protein with two variably occupied N-glycosylation sites. In general, GPI-anchor and N-glycosylation direct proteins to
Berta Puig +6 more
doaj +1 more source
Dynamics and Interactions of GPI-Linked lynx1 Protein with/without Nicotinic Acetylcholine Receptor in Membrane Bilayers [PDF]
The Journal of Physical Chemistry B, 2020 Nicotinic acetylcholine receptors (nAChRs) participate in diverse biological processes, such as mood, learning, and addiction. Glycosylphosphatidylinositol-linked lynx1 is an allosteric modulator of nAChR function, including shifts in agonist sensitivity, reduced desensitization, and slower recovery from desensitization.
Chuqiao Dong +5 more
openaire +2 more sources
Display of GPI-anchored anti-EGFR nanobodies on extracellular vesicles promotes tumour cell targeting [PDF]
Journal of Extracellular Vesicles, 2016 Background: Extracellular vesicles (EVs) are attractive candidate drug delivery systems due to their ability to functionally transport biological cargo to recipient cells.
Sander A. A. Kooijmans +5 more
doaj +1 more source
Glycosyl phosphatidylinositol anchor biosynthesis is essential for maintaining epithelial integrity during Caenorhabditis elegans embryogenesis. [PDF]
PLoS Genetics, 2015 Glycosylphosphatidylinositol (GPI) is a post-translational modification resulting in the attachment of modified proteins to the outer leaflet of the plasma membrane.
Yemima Budirahardja +2 more
doaj +1 more source
The GPI-Linked Protein LY6A Drives AAV-PHP.B Transport across the Blood-Brain Barrier [PDF]
Molecular Therapy, 2019 Efficient delivery of gene therapy vectors across the blood-brain barrier (BBB) is the holy grail of neurological disease therapies. A variant of the neurotropic vector adeno-associated virus (AAV) serotype 9, called AAV-PHP.B, was shown to very efficiently deliver transgenes across the BBB in C57BL/6J mice.
Juliette, Hordeaux +9 more
openaire +2 more sources
A GPI-linked protein that interacts with Ret to form a candidate neurturin receptor [PDF]
Nature, 1997 Glial-cell-line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF mediates its actions through a multicomponent receptor system composed of a ligand-binding glycosyl-phosphatidylinositol (GPI)-linked protein (designated GDNFR ...
R D, Klein +19 more
openaire +2 more sources