Results 101 to 110 of about 56,362 (206)

PGAP3 is expressed at increased levels in asthmatic ASM and is associated with increased ASM proliferation, contractility and expression of GATA3 and ALOX5.

PLoS ONE
Post-GPI Attachment to Proteins phospholipase 3 (PGAP3) is a glycosylphosphatidylinositol (GPI) anchor-remodeling gene found on chromosome 17q12-21, which is a locus highly linked to asthma. Genetic association studies have linked PGAP3 SNPs to increased
Eric Leslie, Marina Miller, Allison Lafuze, Sofya Svyatskaya, Gil-Soon Choi, Joshua L Kennedy, Yung-An Huang, Taylor A Doherty, David H Broide   +8 more
doaj   +1 more source

Identification and functional characterization of a highly divergent N-acetylglucosaminyltransferase I (TbGnTI) in Trypanosoma brucei [PDF]

, 2014
Trypanosoma brucei expresses a diverse repertoire of N-glycans, ranging from oligomannose and paucimannose structures to exceptionally large complex N-glycans.
Acosta-Serrano, Angela Mehlert, Atrih, Bangs, Bangs, Bendiak, Chang, Cross, Cross, Cross, Di Wu, Doering, Ferguson, Ferguson, Giraudo, Grab, Güther, Harpaz, Ho, Hwa, Ioffe, Izquierdo, Izquierdo, Izquierdo, Izquierdo, Izquierdo, Joao A. Rodrigues, Jones, Kornfeld, Leal, Lombard, M.Lucia S. Güther, Manthri, Manuela Damerow, Mazhari-Tabrizi, Mehlert, Mehlert, Mehlert, Mehlert, Mehlert, Metzler, Michael A.J. Ferguson, Milne, Nagamune, Narimatsu, Nolan, Paschinger, Paulson, Pays, Rovis, Schachter, Sonnhammer, Tabas, Tazeh, Urbaniak, Vella, Visser, Wiggins, Wirtz, Wiśniewski, Zamze   +60 more
core   +3 more sources

Exploring the causal relationship between plasma proteins and postherpetic neuralgia: a Mendelian randomization study

Frontiers in Neurology
BackgroundThe proteome represents a critical reservoir of potential therapeutic targets for neurological diseases. This study aims to investigate the causal relationship between plasma proteins and postherpetic neuralgia.MethodsWe performed a two-sample ...
Qiuyu Wei, Shaoyong Yu, Yi Luo, Xinghui Song, Pin Qin, Rongji Li, Weichao Sun, Weichao Sun, Jin Wang, Gang Wu   +9 more
doaj   +1 more source

RFT1 Protein Affects Glycosylphosphatidylinositol (GPI) Anchor Glycosylation [PDF]

, 2016
The membrane protein RFT1 is essential for normal protein N‑glycosylation, but its precise function is not known. RFT1 was originally proposed to translocate the glycolipid Man5GlcNAc2-PP-dolichol (needed to synthesize N-glycan precursors) across the ...
Acosta Serrano, Alvaro
core   +1 more source

Semaphorin-7A is an erythrocyte receptor for P. falciparum merozoite-specific TRAP homolog, MTRAP.

PLoS Pathogens, 2012
The motility and invasion of Plasmodium parasites is believed to require a cytoplasmic actin-myosin motor associated with a cell surface ligand belonging to the TRAP (thrombospondin-related anonymous protein) family.
S Josefin Bartholdson, Leyla Y Bustamante, Cecile Crosnier, Steven Johnson, Susan Lea, Julian C Rayner, Gavin J Wright   +6 more
doaj   +1 more source

Effects of methylmercury exposure on the transcriptomes of cell lines from the rat central nervous system

Discover Toxicology
Methylmercury (MeHg) can have profound effects on cells of the nervous system, leading to DNA damage, oxidative stress, neuroinflammation, and cell death. In this study, transcriptomic changes in neuronal (B103) and glial (C6) cell lines from rat (Rattus
Laís Teixeira Bonfim, Carolina Koury Nassar Amorim, Edivaldo Herculano Corrêa de Oliveira, Wallax Augusto Silva Ferreira   +3 more
doaj   +1 more source

Protein lipidation in health and disease: molecular basis, physiological function and pathological implication

Signal Transduction and Targeted Therapy
Posttranslational modifications increase the complexity and functional diversity of proteins in response to complex external stimuli and internal changes.
Yuan Yuan, Peiyuan Li, Jianghui Li, Qiu Zhao, Ying Chang, Xingxing He   +5 more
doaj   +1 more source

DETECTION AND FOLLOW UP OF PNH CLONE BY MEASURING CD55 AND CD59 EXPRESSION ON NEUTROPHILS

Zdravniški Vestnik, 2004
Background. Paroxysmal nocturnal haemoglobinuria (PNH) is an acquired clonal haematopoietic stem cell disorder characterised by intravascular haemolysis, bone marrow failure and increased tendency to thrombosis.
Uroš Mlakar, Darja Žontar
doaj  

The CAMP-binding Ectoprotein from Saccharomyces cereuisiae Is Membrane-anchored by Glycosyl-Phosphatidylinositol [PDF]

, 1992
Saccharomyces cerevisiae contains an amphiphilic CAMP-binding glycoprotein at the outer face of the plasma membrane (M, = 54,000). It is converted to a hydrophilic form byt reatment withg lycosyl-phosphatidylinositol- specific phospholipases C and D ...
Bandlow, Wolfhard, Fiedler, Franz, Müller, Günter, Schubert, Karin   +3 more
core  

Evolutionary descent of prion genes from a ZIP metal ion transport ancestor [PDF]

, 2009
In the more than 20 years since its discovery, both the phylogenetic origin and cellular function of the prion protein (PrP) have remained enigmatic.
David Westaway, Gerold Schmitt-Ulms, Holger Wille, Joel C. Watts, Sepehr Ehsani   +4 more
core   +1 more source