Results 121 to 130 of about 508,309 (264)

Gene turnover in the common ancestor of all C4 grasses

PLANTS, PEOPLE, PLANET, EarlyView.
Understanding how plants evolve more efficient photosynthesis is important in a warming world where improving crop productivity and resilience is a global priority. By generating the first reference genomes for an early‐diverging group of grasses called the Aristidoideae, we were able to reconstruct the genetic makeup of the last common ancestor of all
Lara Pereira, Ahmed S. Alenazi, Sahr Mian, Ilia J. Leitch, Pascal‐Antoine Christin, Colin P. Osborne, Luke T. Dunning   +6 more
wiley   +1 more source

The photoswitchable ABAMIs for the future regulation of GWT1 in a spatiotemporal level

Smart Molecules, EarlyView.
The GWT1‐targeted azobenzene‐aminopyridine derivatives (ABAMIs), sensitive to the light at wavelengths from 365 to 520 nm, are separately developed as photochromic ligands to regulate bioactivity as well as the GWT1 functions. These molecules are smart tools in photopharmacological studies, giving an innovative method for understanding functional GWT1 ...
Qian Ding, Zongying Li, Zaiwei Xiao, Siting Zhang, Zimai Liu, Xiaoguang Shao, Zhong Li, Wen Fu, Xusheng Shao   +8 more
wiley   +1 more source

The developmental cell biology of Trypanosoma brucei [PDF]

, 2005
Trypanosoma brucei provides an excellent system for studies of many aspects of cell biology, including cell structure and morphology, organelle positioning, cell division and protein trafficking. However, the trypanosome has a complex life cycle in which
Matthews, Keith R
core   +2 more sources

Rapid generation of prion disease models using AAV‐delivered PrP variants in knockout mice

Brain Pathology, EarlyView.
We developed a rapid AAV‐based system to generate prion disease models in weeks rather than months. Following systemic AAV9P31 delivery of modified PrP to knockout mice, we achieved brain‐wide expression and successful propagation of both classical (RML) and atypical (GSS‐A117V) prion strains.
Maitena San‐Juan‐Ansoleaga, Eva Fernández‐Muñoz, Jorge M. Charco, Enric Vidal, Diego Herrero‐Martínez, Josu Galarza‐Ahumada, Cristina Sampedro‐Torres‐Quevedo, Samanta Giler, Mariví Geijo, Gloria González‐Aseguinolaza, Hasier Eraña, Joaquín Castilla   +11 more
wiley   +1 more source

Exploitation of reverse vaccinology and immunoinformatics as promising platform for genome-wide screening of new effective vaccine candidates against Plasmodium falciparum

BMC Bioinformatics, 2019
Background In the current scenario, designing of world-wide effective malaria vaccine against Plasmodium falciparum remain challenging despite the significant progress has been made in last few decades.
Manisha Pritam, Garima Singh, Suchit Swaroop, Akhilesh Kumar Singh, Satarudra Prakash Singh   +4 more
doaj   +1 more source

CD90 Promotes Gastric Cancer Progression by Regulating SLC1A5‐Mediated Glutamine Metabolism Through YY1

Cancer Science, EarlyView.
The CD90‐YY1‐SLC1A5 axis plays a significant role in gastric cancer. CD90 promotes the binding of YY1 to the SLC1A5 promoter. CD90 regulates SLC1A5‐mediated glutamine metabolism and ferroptosis. ABSTRACT CD90 (THY1) is a cell surface glycoprotein that plays a crucial role in the occurrence and development of various malignant tumors.
Zihua Zhou, Siyi Liu, Chenyu Zhang, Jun Deng, Lin Liang, Yanhong Zhou   +5 more
wiley   +1 more source

PGAP3 is expressed at increased levels in asthmatic ASM and is associated with increased ASM proliferation, contractility and expression of GATA3 and ALOX5.

PLoS ONE
Post-GPI Attachment to Proteins phospholipase 3 (PGAP3) is a glycosylphosphatidylinositol (GPI) anchor-remodeling gene found on chromosome 17q12-21, which is a locus highly linked to asthma. Genetic association studies have linked PGAP3 SNPs to increased
Eric Leslie, Marina Miller, Allison Lafuze, Sofya Svyatskaya, Gil-Soon Choi, Joshua L Kennedy, Yung-An Huang, Taylor A Doherty, David H Broide   +8 more
doaj   +1 more source

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

The FEBS Journal, EarlyView.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos   +4 more
wiley   +1 more source

Exploring the causal relationship between plasma proteins and postherpetic neuralgia: a Mendelian randomization study

Frontiers in Neurology
BackgroundThe proteome represents a critical reservoir of potential therapeutic targets for neurological diseases. This study aims to investigate the causal relationship between plasma proteins and postherpetic neuralgia.MethodsWe performed a two-sample ...
Qiuyu Wei, Shaoyong Yu, Yi Luo, Xinghui Song, Pin Qin, Rongji Li, Weichao Sun, Weichao Sun, Jin Wang, Gang Wu   +9 more
doaj   +1 more source

Novel applications of shotgun phage display [PDF]

, 2004
In a shotgun phage display library, theoretically, the entire proteome of a bacterium is represented. Phages displaying specific polypeptides can be isolated by affinity selection, while the corresponding gene remains physically linked to the gene ...
Rosander, Anna
core